Basic information
- CAS
142852-50-4- Standard SMILES
O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2c(c1)NCCCC2- InChIKey
PMBLXLOXUGVTGB-UHFFFAOYSA-N- Molecular formula
- C25H32N2O
- Average molar mass
- 376.5 g/mol
- Monoisotopic mass
- 376.25146365
Overview
Zanapezil is a member of piperidines.
Names & identifiers
- Preferred name
- Zanapezil
- IUPAC
- 3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one
- English name
- ZANAPEZIL
- Molecular formula
- C25H32N2O
- Molecular weight
- 376.53
Names & synonyms
Zanapezil142852-50-4Zanapezil [INN]3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-oneZanepezilzanapeziloUNII-0A0800O89N0A0800O89N1-Propanone, 3-(1-(phenylmethyl)-4-piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-zanapezilumzanapezil funarateRefChem:195842
Show more names
TAK-147 free base1-Propanone, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-
Zanapezil (free base)Zanapezil free baseCHEMBL750133-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-yl)propan-1-oneNCGC00183005-01SCHEMBL678642orb1691710SCHEMBL29366424
Database identifiers
- CAS
142852-50-4- PubChem CID
- 198752
- DTXSID
DTXSID90861521- ChEMBL
CHEMBL75013- ChEBI
Properties
Computed structural properties
- XLogP
- 4.9
- Topological polar surface area
- 32.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 6
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 479
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- form
- Solid
- color
- White to light yellow
- FDA UNII
- 0 A0800O89N · 0A0800O89N
Chemistry & industry
Pharmacology
Pharmacodynamics
Zanapezil is an acetylcholinesterase inhibitor being developed by Takeda for the treatment of dementia in subjects with Alzheimer’s disease. In May 2003, the company discontinued development of the compound due to a lack of a dose-dependent effect in the trials.
Mechanism of Action
Zanapezil inhibits the degradation of acetylcholine, a neurotransmitter, to prevent the reduction of cerebral acetylcholine levels and to enhance the mental function of patients with dementia. It is expected to act selectively on the central nervous system, resulting in fewer peripheral adverse reactions.
Applications
UsesZanapezil is a acetylcholinesterase inhibitor that is a potential drug for treating Alzheimer disease.
Upstream & downstream products
Upstream raw materials
Suppliers3 total
上海立崎生物医学研究中心18014399201 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
ChemeGen 中国18818260767 · [email protected]
Additional notes
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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