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Ethyl glycidyl ether

HCID 19919
NotesReactions
Basic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
Substructure searchFind similar structures

Basic information

CAS
4016-11-9
Standard SMILES
CCOCC1CO1
InChIKey
HQCSZRIVJVOYSU-UHFFFAOYSA-N
Molecular formula
C5H10O2
Average molar mass
102.13 g/mol
Monoisotopic mass
102.06807956

Overview

1,2-epoxy-3-ethoxypropane appears as a colorless liquid. Less dense than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption.

Names & identifiers

Preferred name
Ethyl glycidyl ether
IUPAC
2-(ethoxymethyl)oxirane
English name
Ethyl glycidyl ether
Molecular formula
C5H10O2
Molecular weight
102.13

Names & synonyms

ETHYL GLYCIDYL ETHER(Ethoxymethyl)oxirane1,2-Epoxy-3-ethoxypropaneOxirane, 2-(ethoxymethyl)-ZSP9639OMHNSC 71436glycidyl ethyl etherCCRIS 1018HSDB 6080EINECS 223-671-3NSC-71436UN2752
Show more names
2-(Ethoxymethyl)oxirane(ethoxymethyl)-oxiranEthylGlycidylEther>Ethyl glycidyl ether,98%1,2-epoxy-3-ethoxy-propanOxiranylmethylethyl ether3-Ethoxy-1,2-epoxypropane1-ETHOXY-2,3-EPOXYPROPANE
UNII-ZSP9639OMHBRN 01026692,3-epoxypropyl ethyl ether1,2-Epoxy-3-ethyloxy propaneDTXSID90871049UN 27525-17-03-00010 (Beilstein Handbook Reference)1,2Epoxy3ethoxypropane

Database identifiers

CAS
4016-11-9
PubChem CID
19919
DTXSID
DTXSID90871049
UNII
ZSP9639OMH
EC Number
223-671-3
Nikkaji
J35.203I

Properties

Computed structural properties

XLogP
0.1
Topological polar surface area
21.8 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
2
Rotatable bonds
3
Heavy atoms
7
Formal charge
0
Complexity
54

Experimental & physicochemical properties

Chemical ClassesFlammable agents - 2nd degree
PolymersPlastics & Rubber -> Glycidyl Ethers
LogP0.27
Vapor Pressure31.5 [mmHg]
Physical Description · 2 items

1,2-epoxy-3-ethoxypropane appears as a colorless liquid. Less dense than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption.

Colorless liquid; [CAMEO]

Physicochemical properties

Boiling point
128 °C · 128 °C
Density
0.94 · 0.94
refractive index
1.4075 · 1.4075-1.4095
Flash point
47 °C · 47 °C
storage temp.
Flammables area
form
Liquid
color

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Warning

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P264, P264+P265, P270, P273, P280, P301+P317, P303+P361+P353, P305+P351+P338, P330, P337+P317, P370+P378, P391, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 2 items

TP - indicates a substance that is the subject of a proposed TSCA section 4 test rule.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelFlammable Liquid
Fire Hazards · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Health Hazards · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

· Inhalation or contact with material may irritate or burn skin and eyes.

Hazards SummaryHighly flammable and polymerizable; May cause severe irritation; [CAMEO] An irritant; Inhalation of high concentrations can cause CNS depression; [MSDSonline] See GLYCIDYL ETHERS.
DOT ID and Guide2752 127
Reactive Group

Chemistry & industry

Uses & manufacturing

Uses · 3 items

No known current commercial use or production in the US; [HSDB]

Plastic Composites Manufacturing [Category: Industry]

NO EVIDENCE OF CURRENT COMMERCIAL USE IN U.S.

U.S. Exports · 2 items

(1979) No Data

(1981) No Data

U.S. Imports · 2 items

(1979) No Data

(1981) No Data

U.S. Production · 2 items

(1979) NOT PRODUCED COMMERCIALLY IN U.S.

(1981) NOT PRODUCED COMMERCIALLY IN U.S.

General Manufacturing InformationOxirane, 2-(ethoxymethyl)-: ACTIVE

Applications

DescriptionEpoxy ethyloxy propane is a colorless, highlyflammable, polymerizable liquid. Molecularweight = 102.15. Flash point = (approx.) 37℃. Mixes withwater; may partially decompose.

General DescriptionA colorless liquid. Flash point near 100°F. Less dense than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption.

Upstream & downstream products

Downstream products

3-Ethoxy-1-chloro-2-propanol1-ethoxy-3-(piperazin-1-yl)propan-2-ol

Suppliers28 total

梯希爱(上海)化成工业发展有限公司

Related reactions

6 records
New reaction record
HRID 461577 reaction equation
HRID 461577As reactantuspto-grants-1977_12
HRID 825369 reaction equation
HRID 825369As reactantTest data from https://doi.org/10.1039/C8SC04228D
HRID 1111840 reaction equation
HRID 1111840As reactantuspto-grants-1978_10
HRID 1535436 reaction equation
HRID 1535436As reactantTraining data from https://doi.org/10.1039/C8SC04228D (1/10)
HRID 2071573 reaction equation
HRID 2071573As reactantuspto-grants-1977_09
HRID 2224229 reaction equation
HRID 2224229As reactantuspto-grants-2008_05

Compound notes

Loading…

On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
Clear colorless
EWG's Food Scores
1 · 1
FDA UNII
9639 OMH · ZSP9639OMH
EPA Substance Registry System
Ethyl glycidyl ether (4016-11-9)
Symbol(GHS)
2 · GHS02,GHS07
Signal word
Warning
Hazard statements
315 · H315-H319-H226
Precautionary statements
501 · P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Hazard Codes
Xi,N,Xn
Risk Statements
36 · 36/37/38-10-51/53-36-22
Safety Statements
37 · 37/39-26-16-61
RIDADR
2752 · UN 2752 (1,2-EPOXY-3-ETHOXYPROPANE)
RTECS
3200000 · TZ3200000
TSCA
TSCA listed
HazardClass
3 · 3
PackingGroup
III
HS Code
29109000 · 29109000
Hazardous Substances Data
4016 · 4016-11-9(Hazardous Substances Data)
Ethers
Reactivity AlertsHighly Flammable
Reactivity Profile · 1 item

An epoxide and ether. Ethers can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.

DOT Emergency Guidelines · 5 items

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Health: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for ETHYL GLYCIDYL ETHER (8 total), please visit the HSDB record page.

DOT Hazard Classification · 4 items

1,2-Epoxy-3-ethoxypropane

UN2752

Class 3 Flammable and combustible liquid (49 eCFR § 173.120)

PG III: the degree of danger presented by the material is minor

Air and Water ReactionsHighly flammable. Soluble with possible partial decomposition in water.

Safety & protection

Fire FightingExcerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:
Accidental Release Measures · 2 items

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

General First Aid:

Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).
Nonfire Spill ResponseExcerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:
Isolation and Evacuation · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

Immediate precautionary measure

Personal Protective Equipment (PPE)Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:
Emergency Response Planning GuidelinesCAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Toxicology

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.
Non-Human Toxicity Excerpts · 2 items

ETHYLGLYCIDYL ETHER WAS TESTED FOR CARCINOGENICITY BY SKIN APPLICATION OF 30 ICR/HA FEMALE SWISS MICE (10% SOLN IN ACETONE) 3 TIMES WEEKLY FOR A DURATION OF 544 DAYS. MEDIAN SURVIVAL DAYS WAS 544 WITH NO SKIN DAMAGE AND NO EVIDENCE OF CARCINOGENESIS.

THE MUTAGENIC POTENTIALS OF GLYCIDYL ETHERS HAVING STRAIGHT ALKYL CHAINS OF 2,4,6,8,10,12, AND 14 CARBONS ATOMS WERE EXAMINED IN A BATTERY OF IN VITRO ASSAYS. THE BATTERY CONSISTS OF THE SALMONELLA MAMMALIAN MICROSOME ASSAY, THE L5178Y MOUSE LYMPHOMA ASSAY, AND UNSCHEDULED DNA SYNTHESIS USING W138 CELLS. ALL THE ETHERS THROUGH C-4 SHOWED A DEFINITE RESPONSE WHILE THE C-8 OR HIGHER ETHERS SHOWED VERY WEAK OR NO RESPONSES.

Safety data

tsca
TSCA listed
rtecs
TZ3200000
ridadr
UN 2752 (1,2-EPOXY-3-ETHOXYPROPANE)
hs_code
29109000
risk_code
36/37/38-10-51/53-36-22
Signal word
Warning
Symbol(GHS)
GHS02,GHS07
hazard_code
Xi,N,Xn
safety_code
37/39-26-16-61
hazard_class
3
packing_group
III
Hazard statements
H315-H319-H226
Precautionary statements
P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Hazardous Substances Data
4016-11-9(Hazardous Substances Data)
021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
安耐吉化学&3A(安徽泽升科技股份有限公司)400-0056266 · [email protected]
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赛默飞世尔科技(中国)有限公司800-810-5118 · [email protected]
南京精瑞久安生物技术有限公司025-58196018 800028039 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
广东翁江化学试剂有限公司0751-2886766 13927870850 · [email protected]
启源(广东)医药化工有限公司18026564465 · [email protected]
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成都华纯科技有限公司400-1166-196 15982826727 · [email protected]
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TCI Chemicals (India) Pvt. Ltd.[email protected]
Aladdin Scientific[email protected]
上海宝杨宝欣生物科技有限公司021-56698539 19921169802 · [email protected]
山东天铭生物科技发展有限责任公司400-9019001 400-901-9001
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HANGZHOU LEAP CHEM CO., LTD.+86-571-87711850 +8619957148339 · [email protected]
北京新研汇医药研发有限公司13969155946 · [email protected]
AFINE CHEMICALS LIMITED+86-571-85134551 +86-18958018566 · [email protected]
陕西缔都化学有限公司17691182729 17392216275 · [email protected]