Ac-Asp-Glu-Val-Asp-MCA

HCID 1992

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Basic information

CAS: 169332-61-0
Standard SMILES: CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(=O)O)C(=O)Nc1ccc2c(C)cc(=O)oc2c1)C(C)C
InChIKey: ALZSTTDFHZHSCA-UHFFFAOYSA-N
Molecular formula: C30H37N5O13
Average molar mass: 675.6 g/mol
Monoisotopic mass: 675.23878624

Names & identifiers

Preferred name: Ac-Asp-Glu-Val-Asp-MCA
IUPAC: 4-[(2-acetamido-3-carboxypropanoyl)amino]-5-[[1-[[3-carboxy-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
English name: AC-DEVD-AMC
Molecular formula: C30H37N5O13
Molecular weight: 675.64

Names & synonyms

C30H37N5O13Ac-Tyr-Val-GlyAc-YVG-OHAc-Asp-Glu-Val-Asp-MCASCHEMBL29445883DTXSID20274347SAP-3171-VSYG-3146Acetyl-L-Aspartyl-L-Glutamyl-L-Valyl-L-Aspartic Acid ?-(4-Methyl-Coumaryl-7-Amide)4-[(2-acetamido-3-carboxy-propanoyl)amino]-5-[[1-[[1-(carboxymethyl)-2-[(4-methyl-2-oxo-chromen-7-yl)amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-5-oxo-pentanoic acidN-Acetyl-alpha-aspartyl-alpha-glutamylvalyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-alpha-asparagineAc-Devd

Show more names

AC-DEVD-AMCAC-DMQD-AMCAC-DEVD-MCAACETYL-DEVD-AMCAC-DEVD-AMC USP/EP/BPAC-ASP-MET-GLN-ASP-AMCAC-ASP-GLU-VAL-ASP-AMCAC-DEVD-AMC AMMONIUM SALT

Database identifiers

CAS: 169332-61-0
PubChem CID: 1992
DTXSID: DTXSID20274347

Properties

Computed structural properties

XLogP: -1.3
Topological polar surface area: 284 Å²
Hydrogen bond donors: 8
Hydrogen bond acceptors: 13
Rotatable bonds: 17
Heavy atoms: 48
Formal charge: 0
Complexity: 1,330

Physicochemical properties

Boiling point: 1200.1 · 1200.1±65.0 °C(Predicted)
Density: 1.423 · 1.423±0.06 g/cm3(Predicted)
storage temp.: -20 °C · -20°C
solubility: 10 mM · DMSO: 10 mM
form: powder
pka: 4.09 · 4.09±0.10(Predicted)
color: white
Sequence: -7 · N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin
InChIKey: ALZSTTDFHZHSCA-RNVDEAKXSA-N
SMILES: C12C(C)=CC(=O)OC1=CC(NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)C)CC(=O)O)=CC=2 |&1:13,21,28,37,r|
UNSPSC Code: 12352209 · 12352209
NACRES: 77 · NA.77
PPE: 95 · Eyeshields, Gloves, type N95 (US)
WGK Germany: 3 · 3
Storage Class: 11 · 11 - Combustible Solids

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

Safety data

PPE: Eyeshields, Gloves, type N95 (US)
wgk: 3
Storage Class: 11 - Combustible Solids

Chemistry & industry

Applications

DescriptionAc-DEVD-AMC is a fluorogenic substrate for caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.

UsesN-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin has been used as a substrate for caspase-3 assay in human colon cancer cell line and in bone marrow mesenchymal stem cells.

Suppliers75 total

阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

成都彼样生物科技有限公司18108052721 · [email protected]

Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]

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