Basic information
- CAS
65678-07-1- Standard SMILES
CC(C)(C)c1cc(C=C(C#N)C#N)cc(Br)c1O- InChIKey
ABBADGFSRBWENF-UHFFFAOYSA-N- Molecular formula
- C14H13BrN2O
- Average molar mass
- 305.17 g/mol
- Monoisotopic mass
- 304.02113
Names & identifiers
- Preferred name
- Tyrphostin AG 1024
- IUPAC
- 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
- English name
- TYRPHOSTIN AG 1024
- Molecular formula
- C14H13BrN2O
- Molecular weight
- 305.17
Names & synonyms
65678-07-1ag1024Tyrphostin AG 1024AG-1024AG 10242-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrileDTXSID502743502-((3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene)propanedinitrileRefChem:192768DTXCID802258302-(3-Bromo-5-(tert-butyl)-4-hydroxybenzylidene)malononitrile2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile
Show more names
TyrphostinCS-241AGS 200HY-10253AG-1024 ，S1234AG-1024 (Tyrphostin)AG1024, 10 mM in DMSOTYRPHOSTIN AG 1024 USP/EP/BPTYRPHOSTIN AG1024AGS 200
MFCD02179365NF4XN6A8V9CHEMBL2218926NCGC00346684-082-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrileQ27074330Tyrphostin AG-1024ABBADGFSRBWENF-UHFFFAOYSA-N
Database identifiers
- CAS
65678-07-1- PubChem CID
- 2044
- DTXSID
DTXSID50274350- ChEMBL
CHEMBL2218926- ChEBI
CHEBI:93757- UNII
- NF4XN6A8V9
- Nikkaji
- J1.587.963G
Properties
Computed structural properties
- XLogP
- 4
- Topological polar surface area
- 67.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 414
Physicochemical properties
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble
- form
- solid
- color
- yellow
- InChI
- 1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3
- InChIKey
- ABBADGFSRBWENF-UHFFFAOYSA-N
- SMILES
- Brc1c(c(cc(c1)C=C(C#N)C#N)C(C)(C)C)O
- FDA UNII
- 4 XN6A8V9 · NF4XN6A8V9
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
- 280 · P280-P305+P351+P338
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 3 · 3
Safety & regulation
Safety data
- wgk
- 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
DescriptionThe binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.
UsesTyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist.
Suppliers85 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
武汉众志诚生物技术有限公司13628624121 13628604890 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
Related reactions
2 records
Compound notes
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