Basic information
- CAS
71897-07-9- Standard SMILES
Cc1cc2ncc(-c3ccccc3)nc2cc1C- InChIKey
FQNCLVJEQCJWSU-UHFFFAOYSA-N- Molecular formula
- C16H14N2
- Average molar mass
- 234.29 g/mol
- Monoisotopic mass
- 234.11569846
Overview
6,7-dimethyl-2-phenylquinoxaline is a quinoxaline derivative. It has a role as a geroprotector.
Names & identifiers
- Preferred name
- AG1295
- IUPAC
- 6,7-dimethyl-2-phenylquinoxaline
- English name
- AG 1295
- Molecular formula
- C16H14N2
- Molecular weight
- 234.3
Names & synonyms
ag1295AG 1295AG-1295RefChem:9152416,7-Dimethyl-2-phenylquinoxaline71897-07-96,7-Dimethyl-2-phenyl-quinoxalineTyrphostin AG12952-Phenyl-6,7-dimethylquinoxalineCHEMBL7724NSC-380341TYRPHOSTIN AG 1295
Show more names
NSC 380341AG 1295 USP/EP/BPTYROPHOSTIN AG1295AG-1295 (NSC 380341AG 1295, 10 mM in DMSOTYRPHOSTIN AG 1295, 99+%AG 1295 PLATELET-DERIVED GROW
Tyrphostin AG-1295BiomolKI_0000192-Phenyl-6,7-dimethylquinoxaline; 6,7-Dimethyl-2-phenylquinoxaline; AG 1295; NSC 380341; Tyrphostin AG 1295; AG-1295MFCD00270912ChemDiv2_000256BiomolKI2_000029cid_2048FWH2FYS649
Database identifiers
- CAS
71897-07-9- PubChem CID
- 2048
- DTXSID
DTXSID10274351- ChEMBL
CHEMBL7724- ChEBI
CHEBI:94668- UNII
- FWH2FYS649
- Nikkaji
- J600.111D
Properties
Computed structural properties
- XLogP
- 3.6
- Topological polar surface area
- 25.8 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 272
Experimental & physicochemical properties
Solubility<0.3 [ug/mL] (The mean of the results at pH 7.4)
Physicochemical properties
- Melting point
- 121 °C · 121 °C
- Boiling point
- 398.3 · 398.3±37.0 °C(Predicted)
- Density
- 1.127 · 1.127±0.06 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- 1.29 · 1.29±0.30(Predicted)
- form
- White solid
- color
- Yellow
- InChI
- 1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
- InChIKey
- FQNCLVJEQCJWSU-UHFFFAOYSA-N
- SMILES
- n1c2c(ncc1c3ccccc3)cc(c(c2)C)C
- FDA UNII
- 2 FYS649 · FWH2FYS649
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 3 · 3
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
DescriptionProtein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 μM). It inhibits PDGF-stimulated DNA synthesis with an IC50 value of 2.5 μM without affecting activity of the EGF receptor.
UsesAG-1295 is a protein tyrosine kinase inhibitor. Antiproliferative agent used in the treatment of atherosclerosis, pulmonary fibrosis, and gliomas.
Suppliers36 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
吉林中科研伸科技有限公司18143011203 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海楼岚生物科技有限公司021-52996696，15000506266 15000506266
江苏倍达医药科技有限公司0512-63009836 18994340901 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
成都莱先生物科技有限公司19982073091 · [email protected]
开封明仁药业有限公司0371-65741762 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海芮晖化工科技有限公司021-31433387 15618786686 · [email protected]
上海超岚化工科技中心QQ：65489617 13301690235 · [email protected]
安徽凯泽合联医药科技有限公司18130062233 · [email protected]
career henan chemical co+86-0371-86658258 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
爆牛贸易重庆有限公司+86-023-6139-8061 +86-86-13650506873 · [email protected]
长沙福臻生物科技有限公司15111215862 18229892877 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海凯为化学科技有限公司021-58461859 15821823057 · [email protected]
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
烟台盛凯伦化学科技有限公司开发区第一分公司13356901049 · [email protected]
成都赛莱斯科技有限公司19982073091 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
苏州致信生物科技有限公司0512-65118909 18100677375 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
北京海特乐思克科技有限公司15210893940; 15116916250 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
上海弘渠生物医药科技有限公司88888888888 · [email protected]
Dideu Industries Group Limited+86-29-81148696 +86-15129568250 · [email protected]
Additional notes
DefinitionChEBI: 6,7-dimethyl-2-phenylquinoxaline is a quinoxaline derivative. It has a role as a geroprotector.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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