Basic information
- CAS
146535-11-7- Standard SMILES
COc1cc2ncc(-c3ccccc3)nc2cc1OC- InChIKey
QNOXYUNHIGOWNY-UHFFFAOYSA-N- Molecular formula
- C16H14N2O2
- Average molar mass
- 266.29 g/mol
- Monoisotopic mass
- 266.10552769
Overview
6,7-dimethoxy-2-phenylquinoxaline is a quinoxaline derivative.
Names & identifiers
- Preferred name
- 6,7-Dimethoxy-3-phenylquinoxaline
- IUPAC
- 6,7-dimethoxy-2-phenylquinoxaline
- English name
- TYRPHOSTIN AG 1296
- Molecular formula
- C16H14N2O2
- Molecular weight
- 266.29
Names & synonyms
146535-11-76,7-Dimethoxy-3-phenylquinoxalinetyrphostin-AG1296DTXSID70163393RefChem:913689DTXCID4085884Tyrphostin AG 12966,7-dimethoxy-2-phenylquinoxalineAG-1296AG 1296Tyrphostin AG1296ag1296
Show more names
1296A 1296Tyrphostin AG 1296 ，S8024TYRPHOSTIN AG 1296 USP/EP/BPTyrphostin AG 1296 (AG 1296)AG-1296 (Tyrphostin AG 1296)Tyrphostin AG1296, 10 mM in DMSO
Quinoxaline, 6,7-dimethoxy-2-phenyl-Tyrphostin AG-1296MFCD002709136,7-Dimethoxy-2-phenyl-quinoxalineBiomolKI2_000061CHEMBL71191KBio2_000142KBio2_005278
Database identifiers
- CAS
146535-11-7- PubChem CID
- 2049
- DTXSID
DTXSID70163393- ChEMBL
CHEMBL71191- ChEBI
CHEBI:93335- Nikkaji
Properties
Computed structural properties
- XLogP
- 2.8
- Topological polar surface area
- 44.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 307
Physicochemical properties
- Boiling point
- 420.2 · 420.2±40.0 °C(Predicted)
- Density
- 1.192 · 1.192±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO.
- pka
- 0.48 · 0.48±0.30(Predicted)
- form
- White solid
- color
- Yellow
- Sensitive
- Light Sensitive
- Stability
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- 1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3
- InChIKey
- QNOXYUNHIGOWNY-UHFFFAOYSA-N
- UNSPSC Code
- 12352200 · 12352200
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
DescriptionProtein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.
UsesTyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.
Upstream & downstream products
Upstream raw materials
Suppliers65 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
上海遐瑞医药科技有限公司+86-021-61551413 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…