HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 205Generated: October 27, 2026
2-Amino-3-hydroxybutanoic acid
Butanoic acid, 2-amino-3-hydroxy- · R-(R*,S*)]-2-Amino-3-hydroxybutanoic acid
https://huagongshe.com/en/chemical/205
Identifiers & Physical Properties
| CAS No. | 144-98-9 |
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| Molecular formula | C4H9NO3 |
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| Average molar mass | 119.12 g/mol |
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| Monoisotopic mass | 119.05824315 g/mol |
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| SMILES | CC(O)C(N)C(=O)O |
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| InChIKey | AYFVYJQAPQTCCC-UHFFFAOYSA-N |
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| PubChem CID | 205 |
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| ChEMBL | CHEMBL30037 |
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| ChEBI | CHEBI:38263 |
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| EC No. | 201-300-6 |
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| DTXSID | DTXSID301015364 |
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Chemical & Physical Properties
| XLogP | -2.9 |
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| Topological polar surface area | 83.6 |
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| Hydrogen bond donors | 3 |
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| Hydrogen bond acceptors | 4 |
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| Rotatable bonds | 2 |
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| Heavy atoms | 8 |
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| Formal charge | 0 |
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| Complexity | 93.3 |
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| Chemical classes | Biological Agents -> Amino Acids and Derivatives |
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| Drugs | Pharmaceuticals |
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| Solubility | Sparingly soluble in waterSoluble in buffer systems pH 5.5Practically insoluble (in ethanol) |
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| Physical Description | Hemihydrate: Solid[Merck Index] White powder[Sigma-Aldrich MSDS]White crystalline powderslight savoury aroma |
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| Boiling point | 345.803±32.00 °C(Press: 760.00 Torr)(predicted) |
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| Density | 1.307±0.06 g/cm3(Temp: 25 °CPress: 760 Torr)(predicted) |
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| Storage conditions | Keep in dark place,Inert atmosphere,Room temperature |
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| pKa (acidity coefficient) | 2.186±0.10(predicted) |
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| FDA UNII | 760PJT2SS0 |
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| GHS pictogram | GHS07 |
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| Signal word | Warning |
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| GHS hazard statements | H302-H315-H319-H335 |
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| GHS precautionary statements | P261-P305+P351+P338 |
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Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 92.2% (214 of 232) of all reports.Not ClassifiedAggregated GHS information provided per 232 reports by companies from 2 notifications to the ECHA C&L Inventory. |
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| Regulatory information | Chemical: DL-Threonine |
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| Other safety information | IMAP assessments - DL-Threonine: Environment tier I assessment |
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| Hazards summary | May cause irritation[Sigma-Aldrich MSDS] |
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| Hazard Classes and Categories | Not Classified |
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| Toxicity summary | L-Threonine is a precursor to the amino acids glycine and serine. It acts as a lipotropic in controlling fat build-up in the liver. May help combat mental illness and may be very useful in indigestion and intestinal malfunctions. Also, threonine prevents excessive liver fat. Nutrients are more readily absorbed when threonine is present. |
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| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
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| Signal word | Warning |
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| GHS pictogram | GHS07 |
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| GHS hazard statements | H302-H315-H319-H335 |
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| GHS precautionary statements | P261-P305+P351+P338 |
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