Bis(D-gluconato-O1,O2)zinc
Basic information
- CAS
4468-02-4- Standard SMILES
O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[Zn]- InChIKey
ZSKINHGFQOKUDM-IYEMJOQQSA-N- Molecular formula
- C12H24O14Zn
- Average molar mass
- 457.7 g/mol
- Monoisotopic mass
- 456.045747
Overview
Zinc(II) gluconate is a dietary zinc supplement.
Names & identifiers
- Preferred name
- Bis(D-gluconato-O1,O2)zinc
- IUPAC
- bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid);zinc
- English name
- Zinc gluconate
- Molecular formula
- C12H22O14Zn
- Molecular weight
- 455.69
Names & synonyms
Bis(D-gluconato-O1,O2)zincRefChem:569037Zinc(II) Gluconate Hydrategluconate zincPleo zincHelshas ZnZinc VerlaGivobio G ZnBioZn-AASUNII-U6WSN5SQ1ZZinc bis(D-gluconato-O1,O2)HSDB 1054
Show more names
RubozincZinc gluconatZinc dihexonatezinc(ii) gluconaterubozineAids002622Aids-002622Zinc complex
Zinc, bis(D-gluconato-O1,O2)-EINECS 224-736-9Bis(D-gluconato-O(sup 1),O(sup 2))zincBis(D-gluconato-O(sup 1),O(sup 2)) zincZinc, bis(D-gluconato-O(sup 1),O(sup 2))-Bis(D-gluconato-O1,O2) zinc (2) zinc D-gluconate (1:2)
Database identifiers
- CAS
4468-02-4- PubChem CID
- 20543
- EC Number
- 224-736-9
Properties
Computed structural properties
- Topological polar surface area
- 277 Ų
- Hydrogen bond donors
- 12
- Hydrogen bond acceptors
- 14
- Rotatable bonds
- 10
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 385
Experimental & physicochemical properties
CosmeticsDeodorant; Skin conditioning
Physicochemical properties
- Melting point
- 172 · 172-175 °C
- Boiling point
- 319 °C · 319°C
- Density
- 1.44 · 1.44[at 20℃]
- vapor pressure
- 0 Pa · 0Pa at 20℃
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in water, practically insoluble in anhydrous ethanol and in methylene chloride.
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- 100 g/ · Soluble in water 100g/ l.
- Merck
- 14 · 14,4456
- Cosmetics Ingredients Functions
- ORAL CAREANTIMICROBIALSKIN CONDITIONINGDEODORANT
- InChI
- InChI=1/2C6H12O7.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/s3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 14.7% (39 of 266) of reports.
Danger
H318 (81.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
P264+P265, P273, P280, P305+P354+P338, P317, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 266 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationREACH registered substance: Bis(D-gluconato-O1,O2)zinc (EC: 224-736-9)
Hazard Classes and CategoriesEye Dam. 1 (81.6%)
Safety & protection
Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (L134)
Chronic Oral: 0.3 mg/kg/day (L134)
Toxicology
TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)
Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)
Exposure RoutesInhalation (L49) ; oral (L49) ; dermal (L49)
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)
Uses & manufacturing
UsesZinc gluconate is used in dietary supplements. (L66)
Use ClassificationCosmetics -> Deodorant; Skin conditioning
Applications
UsesZinc gluconate is an excellent nutrient zinc enhancer, having significant effect for the intellectual and physiological development of infants and young people with its absorption effect being better than inorganic zinc. China provides that it can be used for salt with the usage amount of 800~1000mg/kg; 230~470mg/kg in dairy product; 195~545mg/kg in infant and child food; in cereals and their products: 160~320mg/kg; 40 to 80 mg/kg in beverages and milk beverages.
UsesChelating agent. In high alkalinity bottle washes and other cleansers; in finish removers; in the tanning and textile industry.
UsesZinc gluconate hydrate is used as a food additive, a pharmaceutical intermediate.
Useszinc gluconate helps maintain the skin in good condition and acts as a deodorant by preventing the growth of micro-organisms, such as bacteria, fungi or yeast, in a formulation. Zinc gluconate could also be effectively used in anti-acne products.
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Compound notes
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