2-Amino-6-chloropyridine

HCID 206246
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Basic information

CAS
45644-21-1
Standard SMILES
Nc1cccc(Cl)n1
InChIKey
OBYJTLDIQBWBHM-UHFFFAOYSA-N
Molecular formula
C5H5ClN2
Average molar mass
128.56 g/mol
Monoisotopic mass
128.0141259

Names & identifiers

Preferred name
2-Amino-6-chloropyridine
IUPAC
6-chloropyridin-2-amine
English name
2-Amino-6-chloropyridine
Molecular formula
C5H5ClN2
Molecular weight
128.56

Names & synonyms

2-Amino-6-chloropyridine6-Chloro-2-pyridinamineRefChem:464752629-259-345644-21-16-chloropyridin-2-amine2-Chloro-6-aminopyridine2-Pyridinamine, 6-chloro-MFCD002340686-chloropyridin-2-ylaminePyridine, 2-amino-6-chloro-6-Amino-2-chloropyridine
Show more names
2-Pyridinamine,6-chloro2-CHIORO-6-AMINOPYRIDINE6-Chloropyridine-2-amine2-amino-6-chloro-pyridin6-Chloro-2-pyridineamine
Edoxaban Impurity 356-chloro-pyridin-2-ylamineBRN 01086696-chloro-2-pyridylamine6-chloro-2-aminopyridine6-chloro-2-pyridinylamine2-chloro-6-amino-pyridine4-22-00-04028 (Beilstein Handbook Reference)

Database identifiers

CAS
45644-21-1
PubChem CID
206246
DTXSID
DTXSID20196575
UNII
4YF3S49Y8V
EC Number
629-259-3
Nikkaji
J93.669C

Properties

Computed structural properties

XLogP
0.8
Topological polar surface area
38.9 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
2
Rotatable bonds
0
Heavy atoms
8

Physicochemical properties

Melting point
69 · 69-73 °C
Boiling point
255.7 · 255.7±20.0 °C(Predicted)
Density
1.326 · 1.326±0.06 g/cm3(Predicted)
storage temp.
Keep in dark place,Sealed in dry,Room Temperature
pka
2.76 · 2.76±0.24(Predicted)
form
Powder or Low Melting Solid

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H312 (10.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H332 (10.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H335 (97.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 77 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)；Acute Tox. 4 (10.4%)；Skin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；Acute Tox. 4 (10.4%)；STOT SE 3 (97.4%)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
rtecs
US1813350
hs_code
29333990
risk_code
22-36/37/38
Signal word
Warning

Chemistry & industry

Applications

UsesSubstrate used in a Ni(II)-catalyzed homo-coupling providing diamino-2,2′-bipyridine.

Uses2-Amino-6-chloropyridine used in a Ni(II)-catalyzed homo-coupling providing diamino-2,2′-bipyridine.

Upstream & downstream products

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Related reactions

54 records
New reaction record

Compound notes

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