3-Methoxybenzylamine

Uses3-Methoxybenzylamine is a 3-methoxy derivative of benzylamine. 3-Methoxybenzylamine is one the the metabolites detected in urine after metabolism of dopamine analogues. 3-Methoxybenzylamine showed pla smin inhibitory activity as well as weak inhibition of the essential bacterial cell division protein FtsZ

Uses3-Methoxybenzylamine was used in the preparation of 6-substituted purines.

PreparationPdNPore (2.7 mg, 5 mol%) catalyst and ammonia borane complex (30.86 mg, 1 mmol) were added to a mesoporous reactor. Methanol (3 mL) was added under nitrogen purging, followed by the substrate m-methoxybenzonitrile (58.5 mg, 0.5 mmol). The reactor was placed in an oil bath and reacted at 50 °C for 12 h. The mixture was then purified by column chromatography (silica gel, 200-300 mesh; developing solvent: ethyl acetate:methanol = 2:1) to obtain 65.4 mg of 3-methoxybenzylamine, with a yield of 95%.