Basic information
- CAS
1425-61-2- Standard SMILES
CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)CO)O[C@@H](CO)[C@H](O)[C@H]1O.CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)CO)O[C@@H](CO)[C@H](O)[C@H]1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
CZWJCQXZZJHHRH-YCRXJPFRSA-N- Molecular formula
- C42H88N14O36S3
- Average molar mass
- 1,461.4 g/mol
Overview
Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. Dihydrostreptomycin sulfate inhibits protein synthesis by binding to the 30S ribosomal subunit. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tulemia.
Names & identifiers
- Preferred name
- Dihydrostreptomycin Sulfate
- IUPAC
- bis(2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine);sulfuric acid
- English name
- Dihydrostreptomycin sesquisulfate salt
- Molecular formula
- C21H43N7O16S
- Molecular weight
- 681.67
Names & synonyms
Dihydrostreptomycin sulfate5490-27-7DIHYDROSTREPTOMYCIN SESQUISULFATEDihydrostreptomycin sulfate (USP)Dihydrostreptomycin sequisulphateDTXSID6045824NSC-7567392-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;sulfuric acidT7D4876IUEDTXCID4025824D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)Pfizer-Strep
Show more names
DIDROMYCINE SULFATEWelcome to consult Zhang JunTDIHYDROSTREPTOMYCIN SESQUISULFATE SALDihydrostreptomycin sesquisulfate saltDIHYDROSTREPTOMYCIN SESQUISULFATE SALT USP/EP/BP4-O-[2-O-[2-(Methylamino)-2-deoxy-α-L-glucopyranosyl]-5-deoxy-3-(hydroxymethyl)-α-L-lyxofuranosyl]-N,N'-diamidino-D-streptamine/sulfuric acid,(1:x)
Properties
Computed structural properties
- Topological polar surface area
- 928 Ų
- Hydrogen bond donors
- 32
- Hydrogen bond acceptors
- 42
- Rotatable bonds
- 18
- Heavy atoms
- 95
- Formal charge
- 0
- Complexity
- 993
Experimental & physicochemical properties
Animal DrugsActive Ingredients (Dihydrostreptomycin Sulfate) -> FDA Greenbook
Physicochemical properties
- Melting point
- 200 °C · >200°C (dec.)
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: 50 mg/mL, clear, faintly yellow
- form
- crystalline
- color
- White
- Stability
- Hygroscopic
- InChIKey
- GSPKOIJAMLDYCY-XKIHQDMANA-N
- FDA UNII
- 7 D4876IUE · T7D4876IUE
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
- WGK Germany
- 3 · 3
- RTECS
- 2236000 · WK2236000
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 21.3% (38 of 178) of reports.
Danger
H302 (54.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 178 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Dihydrostreptomycin sulphate: Does not have an individual approval but may be used under an appropriate group standard
Dihydrostreptomycin sulfate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety Information
IMAP assessments - D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (54.5%)
Safety data
- wgk
- 3
- rtecs
- WK2236000
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Uses & manufacturing
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing InformationD-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3): INACTIVE
Applications
UsesA derivative of Streptomycin (S687500) with antimicrobial activity. It is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
Suppliers33 total
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
湖北恒硕化工有限公司027-82830253 13995541600 · [email protected]
Protheragen-ING
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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