Basic information
- CAS
85320-68-9- Standard SMILES
COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1- InChIKey
LVEXHFZHOIWIIP-UHFFFAOYSA-N- Molecular formula
- C18H24N2O5S
- Average molar mass
- 380.5 g/mol
- Monoisotopic mass
- 380.14059304
Overview
Amosulalol is a sulfonamide.
Names & identifiers
- Preferred name
- Amosulalol
- IUPAC
- 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide
- English name
- Amosulalol
- Molecular formula
- C18H24N2O5S
- Molecular weight
- 380.46
Names & synonyms
Amosulalol85320-68-9AmosulalolumC69JI1BAU8DTXSID908688935-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide5-[1-Hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methylbenzenesulfonamideRefChem:112259DTXCID50816951Amosulalol [INN]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamideAmosulalol (INN)
Show more names
Amosulalol USP/EP/BPAmosulalol, 10 mM in DMSOBenzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-Benzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-, (+-)-
(+-)-5-(1-Hydroxy-2-((2-(o-methoxyphenoxy)ethyl)amino)ethyl)-o-toluenesulfonamideAmosulalolum [Latin]UNII-C69JI1BAU8AMOSULALOL [MI]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methyl-benzenesulfonamideAMOSULALOL [WHO-DD]SCHEMBL48933CHEMBL152231
Database identifiers
Properties
Computed structural properties
- XLogP
- 1.2
- Topological polar surface area
- 119 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 9
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 510
Physicochemical properties
- form
- Solid
- color
- White to off-white
- FDA UNII
- 69 JI1BAU8 · C69JI1BAU8
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Applications
DescriptionAmosulalol is a potent antihypertensive with combined alpha and beta blocking properties. Indicated for the treatment of essential hypertension, it appears to possess a minimum of side-effects. Its beta-blocking property reduces the tachycardia associated with alpha-blockers, while its alpha-blocking activity reduces the peripheral vasoconstriction associated with beta-blockade.
Upstream & downstream products
Upstream raw materials
Related reactions
1 records
Compound notes
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