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Epitalon

HCID 219042
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Basic information

CAS
307297-39-8
Standard SMILES
C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O
InChIKey
HGHOBRRUMWJWCU-FXQIFTODSA-N
Molecular formula
C14H22N4O9
Average molar mass
390.35 g/mol
Monoisotopic mass
390.13867829

Overview

Epitalon is an organic molecular entity.

Names & identifiers

Preferred name
Epitalon
IUPAC
(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
English name
Epitalon
Molecular formula
C14H22N4O9
Molecular weight
390.35

Names & synonyms

Epitalon307297-39-8EpithalonEpithaloneAla-Glu-Asp-GlyAE-0 peptideO65P17785GGlycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-alanyl-glutamyl-aspartyl-glycineDTXSID80952957RefChem:921052DTXCID801381023
Show more names
EpithalonAcetateGlycine, L-alanyl-L-a-glutamyl-L-a-aspartyl-ALAGLUASPGLYAla-Glu-Asp-Gly-OHEptaton EpithalonEpithalon(Epitalon) acetateEpitalon, Epithalon TetraPeptideEpithalon, Epithalon Tetra Peptide
(S)-4-((S)-2-aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid64082-79-7EpithalaminL-Alanyl-L-glutamyl-L-aspartyl-glycineEpithalamineEpithalon?UNII-O65P17785G

Database identifiers

CAS
307297-39-8、64082-79-7
PubChem CID
219042
DTXSID
DTXSID80952957
ChEBI
CHEBI:230091
UNII
O65P17785G

Properties

Computed structural properties

XLogP
-5.5
Topological polar surface area
225 Ų
Hydrogen bond donors
7
Hydrogen bond acceptors
10
Rotatable bonds
12
Heavy atoms
27
Formal charge
0
Complexity
607

Physicochemical properties

Boiling point
959.8 · 959.8±65.0 °C(Predicted)
Density
1.466 · 1.466±0.06 g/cm3(Predicted)
storage temp.
-20 °C · Store at -20°C
solubility
250 mg/mL · DMSO: 250 mg/mL (495.67 mM)
pka
3.16 · 3.16±0.10(Predicted)
form
Solid
color
White to off-white
Sequence
Ala-Glu-Asp-Gly
Cosmetics Ingredients Functions
ORAL CARESKIN CONDITIONING - MISCELLANEOUSANTIOXIDANTSKIN PROTECTINGHAIR CONDITIONING
InChIKey
HGHOBRRUMWJWCU-VTCOHLDGNA-N
SMILES
[C@H](CC(=O)O)(C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)C |&1:0,15,24,r|
FDA UNII
65 P17785G · O65P17785G

Chemistry & industry

Applications · 4 items

DescriptionEpitalon (also known as Epithalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.Epitalon is considered the "fountain of youth" peptide. It is a tetra-peptide, which means that it is composed of four amino acid chains. The peptide is used to regulate the cell cycle during telomerase activity. Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes. When telomerase activity is not present (when we age), our cells age. Our telomeres get shorter and begin to die off. If telomerase is activated in our cells, our telomeres lengthen, the cell continues to grow and divide, delaying the aging process. (UT Southwestern Medical Lab)https://www.amisantabarbara.com/epitalon

HistoryEpitalon was discovered and developed by the Russian scientist and gerontologist Professor, Doctor of Medical sciences Vladimir Khavinson of St. Petersburg Institute of Bioregulation and Gerontology, whose research is focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. Epitalon was identified as active component of a bovine pineal gland extract (known as Epithalamin).Low-molecular peptides isolated from pineal gland and Epithalamin of animals were studied in different biologic models. Most all performed scientific studies and clinical trials of Epitalon and Epithalamin have been conducted just by already mentioned St. Petersburg Institute of Bioregulation and Gerontology in Russia, primarily overseen by Professor Vladimir Khavinson, who has been involved in this research already for over 35 years, and has merit not only in the discovery of epitalon, but also in its highly advanced scientific and clinical review. Throughout this time, Epitalon has been extensively investigated in animal and human clinical trials and today is one of the best scientifically investigated peptides.https://beringomega.org

UsesEpitalon is a synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), that is based on a natural peptide called epithalamin extracted from the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.

DescriptionEpithalon Synthetic is a single, non-glycosylated polypeptide chain containing 4 amino acids, having a molecular mass of 390.35 Dalton and a Molecular formula of C14H22N4O9.

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