Basic information
- CAS
64-65-3- Standard SMILES
CCC1(C)CC(=O)NC(=O)C1- InChIKey
ORRZGUBHBVWWOP-UHFFFAOYSA-N- Molecular formula
- C8H13NO2
- Average molar mass
- 155.19 g/mol
- Monoisotopic mass
- 155.09462866
Overview
Bemegride is a white crystalline solid. Sublimes at 212 °F and 200 mm pressure. (NTP, 1992)
Names & identifiers
- Preferred name
- Bemegride
- IUPAC
- 4-ethyl-4-methylpiperidine-2,6-dione
- English name
- 3-Ethyl-3-methylglutarimide
- Molecular formula
- C8H13NO2
- Molecular weight
- 155.19
Names & synonyms
bemegride64-65-33-Ethyl-3-methylglutarimide4-ethyl-4-methylpiperidine-2,6-dioneMethetharimideMegibalMegimideMikedimideEukratonZentraleptinBemegridAhypnon
Show more names
NP-13DPX6573
MalysolMegimidAntibarbiAgipnonBemegrida3-Methyl-3-ethylglutarimideBemegridumbeta-Ethyl-beta-methylglutarimide
Database identifiers
- CAS
64-65-3- PubChem CID
- 2310
- DTXSID
DTXSID0045250- ChEMBL
CHEMBL1214192- ChEBI
CHEBI:92269- UNII
- 57DQA39DO2
- EC Number
- 200-588-0
- Nikkaji
- J1.404D
Properties
Computed structural properties
- XLogP
- 0.7
- Topological polar surface area
- 46.2 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 182
Experimental & physicochemical properties
DrugsDEA NFLIS-Drug Category -> Stimulants
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Melting Point259 to 261 °F (NTP, 1992)
Physical DescriptionBemegride is a white crystalline solid. Sublimes at 212 °F and 200 mm pressure. (NTP, 1992)
Physicochemical properties
- Melting point
- 126 · 126-127 °C(lit.)
- Boiling point
- 279 °C · 279°C (rough estimate)
- Density
- 1.1174 · 1.1174 (rough estimate)
- refractive index
- 1.486 · 1.4860 (estimate)
- storage temp.
- 2 · Sealed in dry,2-8°C
- Water Solubility
- Soluble in water
- solubility
- 31 · DMSO:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)Ethanol:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)
Safety & regulation
GHS classification
GHS Classification
Danger
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available. It is probably not flammable. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: When heated to decomposition it emits toxic fumes. (NTP, 1992)
Reactive GroupAmides and Imides
Reactivity Profile
BEMEGRIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 2 (100%)
Safety & protection
Chemistry & industry
Pharmacology
ATC Code
R - Respiratory system
QR - Respiratory system
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.
Drugs used for their effects on the respiratory system.
Uses & manufacturing
General Manufacturing Information2,6-Piperidinedione, 4-ethyl-4-methyl-: INACTIVE
Applications
UsesCNS stimulant;GABA antagonist
General DescriptionWhite crystalline solid. Sublimes at 212°F and 200 mm pressure.
Suppliers77 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海麦克林生化科技股份有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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