DL-Arginine
L-ARGININE HCL · L-ARGININE MONOHYDROCHLORIDE · Arginine HCL · ARGININE HYDROCHLORIDE · L-Arginine HCI · H-ARG-OH HCL · L-Arginine HCl FCC · Arginine hydrochloride CRS
Identifiers & Physical Properties
| CAS No. | 1119-34-2 |
|---|---|
| Molecular formula | C6H14N4O2 |
| Average molar mass | 174.2 g/mol |
| SMILES | NC(N)=NCCCC(N)C(=O)O |
| InChIKey | ODKSFYDXXFIFQN-UHFFFAOYSA-N |
| PubChem CID | 232 |
| ChEBI | CHEBI:29016 |
| EC No. | 230-571-3 |
| DTXSID | DTXSID8022618 |
Chemical & Physical Properties
| XLogP | -4.2 |
|---|---|
| Topological polar surface area | 128 |
| Hydrogen bond donors | 4 |
| Hydrogen bond acceptors | 4 |
| Rotatable bonds | 5 |
| Heavy atoms | 12 |
| Formal charge | 0 |
| Complexity | 176 |
| Drugs | Pharmaceuticals |
| Melting point | 226-230 °C(lit.) |
| alpha | 22 º (c=8,6N HCl) |
| Boiling point | 235℃[at 101 325 Pa] |
| Bulk density | 1250kg/m3 |
| Density | 1.42 |
| Vapor pressure | <1 Pa (20 °C) |
| FEMA | 3819 | L-ARGININE |
| Storage conditions | 2-8°C |
| Solubility | H2O: 100 mg/mLSoluble in water. Slightly soluble in hot alcohol. |
| Physical state | powder |
| pKa (acidity coefficient) | 1[at 20 ℃] |
| Color | white |
| Odor | odorless |
| PH Range | 5.5 - 7 |
| pH | 5.5-7.0 (25℃, 1M in H2O) |
| Biological source | non-animal source |
| optical activity | [α]20/D +22.0±0.5°, c = 5% in 5 M HCl |
| Sensitivity | Hygroscopic |
| λmax | λ: 260 nm Amax: ≤0.2λ: 280 nm Amax: ≤0.1 |
| Merck | 14,780 |
| BRN | 3631658 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major applications | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| Cosmetic Ingredient Review (CIR) | L-Arginine hydrochloride (1119-34-2) |
| InChI | 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)1H/t4-/m0./s1 |
| InChIKey | KWTQSFXGGICVPE-WCCKRBBISA-N |
| SMILES | Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O |
| LogP (partition coefficient) | -8.5--3.24 at 25℃ |
| CAS DataBase Reference | 1119-34-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | F7LTH1E20Y |
| NCI Drug Dictionary | arginine hydrochloride |
| ATC code | B05XB01 |
| EPA Substance Registry System | L-Arginine, monohydrochloride (1119-34-2) |
| UNSPSC Code | 85151701 |
| NACRES | NA.26 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319 |
| GHS precautionary statements | P305+P351+P338 |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard symbols | Xi,Xn |
| Risk statements (R) | 37-36/38-36/37/38-20/21/22 |
| Safety statements (S) | 37/39-26-24/25-36 |
| Water hazard class (WGK) | 2 |
| RTECS number | CF1995500 |
| F | 3-10 |
| TSCA inventory status | TSCA listed |
| Customs code | 29252000 |
| Storage class | 11 - Combustible Solids |
| Toxicity | LD50 orally in Rabbit: 12000 mg/kg |
| REACH registrations | Active |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 2% (3 of 150) of reports.WarningH315 (70.7%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 150 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatory information | Arginine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Hazard Classes and Categories | Skin Irrit. 2 (70.7%) |
| F | 3-10 |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Water hazard class (WGK) | 2 |
| TSCA inventory status | TSCA listed |
| RTECS number | CF1995500 |
| Customs code | 29252000 |
| Toxicity | LD50 orally in Rabbit: 12000 mg/kg |
| Risk statements (R) | 37-36/38-36/37/38-20/21/22 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi,Xn |
| Safety statements (S) | 37/39-26-24/25-36 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H315-H319 |
| REACH registrations | Active |
Applications & Uses
Description
L-Arginine hydrochloride is a salt form of L-Arginine, where hydrochloric acid is added to enhance stability and solubility. Arginine hydrochloride is a L-alpha-amino acid. An essential amino acid that is physiologically active in the L-form. L-Arginine might be effective at lowering blood pressure, reducing the symptoms of angina and PAD , and treating erectile dysfunction due to a physical cause.
Uses
gastric acid depressant
Uses
L-Arginine monohydrochloride is used in the treatment of heart and circulatory diseases. It is a precursor of nitric oxide synthesis that induces vasodilation in vivo, there by relaxing blood vessels. It is also used in the treatment of angina and other cardiovascular problems. It is an important intermediate in the urea cycle and involved in the detoxification of nitrogenous wastes. It is commonly used in cell culture media and drug development.
Uses
An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).