Basic information
- CAS
7101-51-1- Standard SMILES
COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1- InChIKey
XBBDACCLCFWBSI-ZETCQYMHSA-N- Molecular formula
- C10H13NO4
- Average molar mass
- 211.21 g/mol
- Monoisotopic mass
- 211.0844579
Overview
Melevodopa is a tyrosine derivative.
Names & identifiers
- Preferred name
- Melevodopa
- IUPAC
- methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
- English name
- (S)-2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid methyl ester
- Molecular formula
- C10H13NO4
- Molecular weight
- 211.21
Names & synonyms
Melevodopa7101-51-1L-Dopa methyl esterLevodopa methyl esterlevometmethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoateChf-1301M30686U4X4DTXSID9048433methyl L-dopamelevodopumRefChem:156332
Show more names
DOPA-METHYLESTERMethyl 3-hydroxy-L-tyrosinatemethyl (S)-2-amino-3-(4-chlorophenyl)propanoate hydrochloride(S)-2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid methyl ester
DTXCID5028407N04BA04Melevodopa [INN](S)-Methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate3-Hydroxy-L-tyrosine methyl esterL-Tyrosine, 3-hydroxy-, methyl ester(-)-3,4-Dihydroxy-L-phenylalanine, methyl esterMelevodopa (INN)
Database identifiers
- CAS
7101-51-1- PubChem CID
- 23497
- DTXSID
DTXSID9048433- ChEMBL
CHEMBL1328898- ChEBI
CHEBI:134880- UNII
- M30686U4X4
- Nikkaji
- J33.787K
Properties
Computed structural properties
- XLogP
- -0.2
- Topological polar surface area
- 92.8 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 221
Physicochemical properties
- Boiling point
- 350.89 °C · 350.89°C (rough estimate)
- Density
- 1.2545 · 1.2545 (rough estimate)
- refractive index
- 1.515 · 1.5150 (estimate)
- storage temp.
- 2 · 2-8°C
- form
- solid
- pka
- 9.67 · 9.67±0.20(Predicted)
- color
- White
- FDA UNII
- 30686 U4X4 · M30686U4X4
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 280 · P280-P304+P340
- HS Code
- 2922500090 · 2922500090
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- hs_code
- 2922500090
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P280-P304+P340
Chemistry & industry
Pharmacology
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological ClassificationAgents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
Applications
DescriptionCHF-1301 was launched as an injection in Italy for the treatment of patients with Parkinson's disease, particularly those with complications in their clinical responses. CHF-1301 is the methyl ester of L-Dopa (levodopa), the immediate precursor of dopamine. Thus, this prodrug is more soluble in water at physiological pH, better absorbed and slowly transformed into levodopa in vivo; it consequently improves the duration of action and prevents the rapid fluctuations in response or involontary movements (dyskinesia) observed during chronic treatment with levodopa. In patients with a delayed effect of levodopa (on-phenomenon) or a severe resistance to L-Dopa (off-phenomenon), CHF- 1301 significantly improves the onset and the stability of the'response.
Upstream & downstream products
Downstream products
Suppliers12 total
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
Hangzhou Sage Chemical Co., Ltd.+86057186818502 13588463833 · [email protected]
常州科化生物科技有限公司0519-68985668 13685222090 · [email protected]
上海相辉医药科技有限公司13761987713 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
深圳市创鑫生物科技有限公司13417589054 · [email protected]
江苏艾康生物医药研发有限公司025-66061636 19370895928 · [email protected]
深圳市创鑫生物科技有限公司13417589054 · [email protected]
Aromsyn Co., Ltd.+86-0571-85585865 +86-13336024896 · [email protected]
上海语锌医药科技有限公司15921286451; 15921286451 · [email protected]
DONBOO AMINO ACID COMPANY13063595538 · [email protected]
Additional notes
DefinitionChEBI: Melevodopa is a tyrosine derivative.
Related reactions
2 records
Compound notes
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