Basic information
- CAS
3370-69-2- Standard SMILES
O=c1[nH]c(=O)n(C2OC(CO)C(O)C2O)cc1Br- InChIKey
AGFIRQJZCNVMCW-MNCSTQPFSA-N- Molecular formula
- C9H11BrN2O6
- Average molar mass
- 323.1 g/mol
- Monoisotopic mass
- 321.98005
Names & identifiers
- Preferred name
- 5-Bromouracil ribonucleoside
- IUPAC
- 5-bromo-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- English name
- 2,4 (1H, 3H)-Pyrimidinedione, 1-.beta.-D-arabinofuranosyl-5-bromo-
- Molecular formula
- C9H11BrN2O6
- Molecular weight
- 323.1
Names & synonyms
5-Bromouracil ribonucleoside3370-69-25-bromo-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione5-bromo-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione2,4 (1H, 3H)-Pyrimidinedione, 1-.beta.-D-arabinofuranosyl-5-bromo-5-bromuridin5-Bromo-1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione82950-04-75-bro-mouridine(-)-5-Bromouridine; NSC 38296;(-)-(5)-BromouridineUracil, 1-.beta.-D-arabinofuranosyl-5-bromo-
Show more names
NSC 822225-BroMoarabinouridine1-(β-D-Arabino-furanosyl)-5-broMouracil1-beta-D-Arabinofuranosyl-5-bromouracil2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-bromo-5-Bromoarabinouridine, 1-(β-D-arabino-furanosyl)-5-bromouracil
NCIOpen2_009259KBioGR_002441KBioSS_002447MLS001166624SCHEMBL654693KBio2_002441KBio2_005009KBio2_007577
Properties
Computed structural properties
- XLogP
- -1.1
- Topological polar surface area
- 119 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 2
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 414
Experimental & physicochemical properties
Solubility>48.5 [ug/mL] (The mean of the results at pH 7.4)
Chemistry & industry
Applications
Uses1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Suppliers12 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
上海遐瑞医药科技有限公司+86-021-61551413 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
上海梅凯科技有限公司021-68689288 15300790979 · [email protected]
郑州格然林医药科技有限公司0371-85513397 · [email protected]
杭州六可生物科技有限公司+86-571-86912261 19975279805 · [email protected]
浙江泽天精细化工有限公司18957127338 · [email protected]
郑州格然林科技有限公司0371-85513397 +86-18610099868 · [email protected]
海蔚化学86-21-51086038 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
Related reactions
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Compound notes
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