Basic information
- CAS
151-73-5- Standard SMILES
CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COP(=O)(O)O- InChIKey
VQODGRNSFPNSQE-UHFFFAOYSA-N- Molecular formula
- C22H30FO8P
- Average molar mass
- 472.4 g/mol
- Monoisotopic mass
- 472.16623307
Names & identifiers
- Preferred name
- 9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
- IUPAC
- [2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] dihydrogen phosphate
- English name
- Betamethasone 21-phosphate disodium
- Molecular formula
- C22H28FNa2O8P
- Molecular weight
- 516.4
Names & synonyms
9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphateRefChem:1074979DTXCID80197200DTXSID20859294LinolosalLinosalCelestone PhosphateBetnesol.beta.-MethasonephosphateCHEMBL2008531SCHEMBL30037357[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] dihydrogen phosphate
Show more names
BETAMETHASONE SODIUM PHOSPHATEBETAMETHASONE 21-DISODIUM PHOSPHATEDurabetasonbentelanBETAMETHASONE 21-PHOSPHATE DISODIUM SALTCelestanBentalanNSC 90616Vista-Methasone
FB181436NCI60_042010NS00015667Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-,disodium salt, (11.beta.,16.beta.)-
Properties
Computed structural properties
- XLogP
- 0.1
- Topological polar surface area
- 141 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 4
- Heavy atoms
- 32
- Formal charge
- 0
- Complexity
- 973
Physicochemical properties
- Melting point
- 206 · 206-211°C
- alpha
- 98 · +98.0~+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)
- storage temp.
- room temp
- solubility
- Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
- form
- Solid
- color
- White to Off-White
- PH
- 7.5 · 7.5~9.0(5g/l, 25℃)
- Water Solubility
- 50 mg/mL, · water: 50mg/mL, clear to very slightly hazy, faintly yellow
- Merck
- 14 · 14,1180
- Stability
- Hygroscopic
- InChIKey
- PLCQGRYPOISRTQ-LWCNAHDDSA-L
- SMILES
- [C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r|
- FDA UNII
- 7 BK02SCL3W · 7BK02SCL3W
- EPA Substance Registry System
- .beta.-Methasone disodium phosphate (151-73-5)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- rtecs
- TU4056500
- hs_code
- 29372290
- Toxicity
- LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90
- risk_code
- 22
- Signal word
- Danger
- Symbol(GHS)
- GHS07,GHS08
- hazard_code
- Xn
- safety_code
- 36
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- target organs
- Liver,Kidney,Endocrine system
- Hazard statements
- H302-H360FD-H373
- Hazard Classifications
- Acute Tox. 4 OralRepr. 1BSTOT RE 2
- Precautionary statements
- P202-P260-P264-P270-P301+P312-P308+P313
Chemistry & industry
Applications
UsesNasal, Ophthalmic, Oral, Parenteral
UsesBetamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.
Suppliers100 total
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
Hebei shuoxi biotechnology co. LTD+8613081092107
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Jai Radhe Sales+(91)-(79)-26431096/65255722 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
上海波以尔化工有限公司[email protected]
武汉菲越生物科技有限公司027-87002654 15827563343 · [email protected]
Related reactions
0 records
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Compound notes
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