Sodium Phosphate, Monobasic, Dihydrate
Sodium dihydrogen orthophosphate · SODIUM BIPHOSPHATE · SODIUM PHOSPHATE, MONOBASIC, DIHYDRATE · SODIUM DIHYDROGEN ORTHOPHOSPHATE DIHYDRATE · SODIUM PHOSPHATE DIHYDRATE · SODIUM DIHYDROGEN PHOSPHATE 2H2O · KH2PO7 · NaH?PO?·2H?O
Identifiers & Physical Properties
| CAS No. | 13472-35-0 |
|---|---|
| Molecular formula | H6NaO6P |
| Average molar mass | 156.01 g/mol |
| Monoisotopic mass | 155.97996882 g/mol |
| SMILES | O.O.O=P([O-])(O)O.[Na+] |
| InChIKey | VBJGJHBYWREJQD-UHFFFAOYSA-M |
| PubChem CID | 23673460 |
| EC No. | 603-853-2 |
| DTXSID | DTXSID90158903 |
Chemical & Physical Properties
| Topological polar surface area | 82.6 |
|---|---|
| Hydrogen bond donors | 4 |
| Hydrogen bond acceptors | 6 |
| Rotatable bonds | 0 |
| Heavy atoms | 8 |
| Formal charge | 0 |
| Complexity | 61.9 |
| Chemical classes | Metals -> Phosphates, Metallic Salts |
| Animal Drugs | Pharmaceuticals -> UK Veterinary Medicines Directorate List |
| Physical Description | Colorless solid[Merck Index] White hygroscopic solid[Acros Organics MSDS] |
| Melting point | 60 °C |
| Density | 1,915 g/cm3 |
| Bulk density | 1000kg/m3 |
| Storage conditions | Store at +5°C to +30°C. |
| Solubility | H2O: 1 M at 20 °C, clear, colorlessSOLUBLE |
| Physical state | Solid |
| Color | White |
| Odor | Odorless |
| PH Range | 4.2 - 4.5 |
| pH | 4.0-4.5 (25℃, 50mg/mL in H2O) |
| Sensitivity | Hygroscopic |
| λmax | λ: 260 nm Amax: 0.085λ: 280 nm Amax: 0.070 |
| Merck | 14,8660 |
| Stability | Stable. |
| Cosmetics Ingredients Functions | BUFFERINGDEODORANTANTI-SEBORRHEIC |
| InChI | 1S/Na.H3O4P.2H2O/c1-5(2,3)4/h(H3,1,2,3,4)2*1H2/q+1/p-1 |
| InChIKey | VBJGJHBYWREJQD-UHFFFAOYSA-M |
| SMILES | O.O.[Na+].OP(O)([O-])=O || O.O.[Na+].OP(O)([O-])=O |
| FDA 21 CFR | 172.892 |
| CAS DataBase Reference | 13472-35-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 5QWK665956 |
| EPA Substance Registry System | Phosphoric acid, monosodium salt (13472-35-0) |
| UNSPSC Code | 12352302 |
| NACRES | NA.25 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| Hazard symbols | Xi |
| Risk statements (R) | 36-36/37/38 |
| Safety statements (S) | 39-26-24/25-36 |
| Water hazard class (WGK) | 1 |
| RTECS number | WA1900500 |
| TSCA inventory status | Yes |
| Customs code | 2835 22 00 |
| Storage class | 11 - Combustible Solids |
| Toxicity | LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 100% (52 of 52) of all reports.Not ClassifiedAggregated GHS information provided per 52 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| Regulatory information | Chemical: Phosphoric acid, monosodium salt, dihydrateSodium phosphate, monobasic, dihydrate: Does not have an individual approval but may be used under an appropriate group standard |
| Other safety information | IMAP assessments - Phosphoric acid, monosodium salt, dihydrate: Human health tier I assessment |
| Hazards summary | Intraperitoneal LD50 (mouse) > 5,008 mg/kg[RTECS] An eye irritant[Acros Organics MSDS] See Sodium phosphate, monobasic. |
| Hazard Classes and Categories | Not Classified |
| Water hazard class (WGK) | 1 |
| TSCA inventory status | Yes |
| RTECS number | WA1900500 |
| Customs code | 2835 22 00 |
| Toxicity | LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg |
| Risk statements (R) | 36-36/37/38 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi |
| Safety statements (S) | 39-26-24/25-36 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
Applications & Uses
Description
Sodium Dihydrogen Phosphate occurs as two forms: the crystal form (dihydrate) called Sodium Dihydrogen Phosphate (crystal) and anhydrous form called Sodium Dihydrogen Phosphate (anhydrous) It is used as an acidity regulator and sequestrant in foods. It is used as a pH buffer (baking powders, fleet enema solution, electroplating baths, and acid cleaners), emulsifier, laboratory reagent, metal phosphating reagent, and textile dyeing/printing auxiliary. It is also used to treat boiled water and waste waster and to remove halogen from waste gases. Furthermore, it is used as a cattle feed supplement, as nutritional supplement in food, in dentrifice formulations, in vitreous enamel frits, for the synthesis of pharmaceuticals, and as a phosphate source for micro-organisms in effluent treatment.
Uses
Sodium dihydrogen phosphate dihydrate acts as buffering capacity reagent in molecular biology, biochemistry and chromatography. It is used in the preparation of biological buffers. It is also used in the purification of antibodies, as a laxative and, in combination with other sodium phosphates.Sodium phosphate monobasic dihydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. Sodium phosphate dibasic is highly hygroscopic and water soluble.Recommended chemicals for the preparation of phosphate buffers are sodium dihydrogen phosphate dihydrate，NaH2PO4.2H2O(mol. wt.156.0)，disodium hydrogen phosphate dihydrate，Na2HPO4.2H2O (mol. wt.178.0), and sodium hydroxide pellets.
Uses
Sodium dihydrogen phosphate dihydrate is typically used as a phosphate buffer system component for downstream biomolecule chromatography steps or final liquid formulation.Due to its low microbial and endotoxin limits, Sodium dihydrogen phosphate dihydrate Emprove Expert is especially suitable for high-risk applications.