Basic information
- CAS
97657-92-6- Standard SMILES
Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1.Cl.Cl- InChIKey
GTWLIQOLGOZTLF-UHFFFAOYSA-N- Molecular formula
- C21H27Cl2N3
- Average molar mass
- 392.4 g/mol
- Monoisotopic mass
- 391.1582033
Overview
See also: Latrepirdine (has active moiety).
Names & identifiers
- Preferred name
- Latrepirdine Dihydrochloride
- IUPAC
- 2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole;dihydrochloride
- English name
- 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
- Molecular formula
- C21H25N3.2ClH
- Molecular weight
- 392.371
Names & synonyms
97657-92-6LATREPIRDINE DIHYDROCHLORIDEDimebon dihydrochlorideDimebolin dihydrochlorideLatrepirdine dihydrochloride [USAN]UNII-8B9414QQ5M8B9414QQ5MDTXSID10243103Latrepirdine dihydrochloride (USAN)DIMEBOLIN DIHYDROCHLORIDE [MI]LATREPIRDINE DIHYDROCHLORIDE [WHO-DD]1H-PYRIDO(4,3-B)INDOLE, 2,3,4,5-TETRAHYDRO-2,8-DIMETHYL-5-(2-(6-METHYL-3-PYRIDINYL)ETHYL)-, DIHYDROCHLORIDE
Show more names
CS-784DiMebone HClDimebon 2HClDiMebone dihydrochlorideLatrepirdine 2HCl ，S1245DiMeboline dihydrochlorideLatrepirdine (Dimebolin) HClDimebone dihydrochloride hydrate
Dimebon HClRefChem:152461DTXCID70165594PF 019135391H-PYRIDO(4,3-B)INDOLE, 2,3,4,5-TETRAHYDRO-2,8-DIMETHYL-5-(2-(6-METHYL-3-PYRIDINYL)ETHYL)-, HYDROCHLORIDE (1:2)1H-Pyrido(4,3-b)indole, 2,3,4,5-tetrahydro-3,6-dimethyl-9-(2-(6-methyl-3-pyridyl)ethyl)-, dihydrochlorideLatrepirdine 2HClLatrepirdine (dihydrochloride)
Properties
Computed structural properties
- Topological polar surface area
- 21.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 3
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 425
Physicochemical properties
- Melting point
- 220 · 220-222 °C
- storage temp.
- Desiccate at RT
- solubility
- 2 O: · H2O: ≥10mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- 2 O: · H2O: ≥10mg/mL
- InChI
- 1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2
- InChIKey
- QQHQMWVYYVVAOV-UHFFFAOYSA-N
- SMILES
- O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4
- FDA UNII
- 8 B9414QQ5M · 8B9414QQ5M
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319
- Precautionary statements
- 305 · P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (50%)
Safety data
- wgk
- 3
- risk_code
- 22-36/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
- 26-36/39
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H315-H319
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2
- Precautionary statements
- P305+P351+P338
Chemistry & industry
Applications
UsesLatrepirdine is an antihistamine drug used initially in Russia. Recently research have explore the potential of Latrepirdine to demonstrate activities against neurodegenerative conditions.
Suppliers75 total
北京华美互利生物化工010-56205725 · [email protected]
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
江苏艾康生物医药研发有限公司025-58851090 19370895928 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
郑州汇聚化工有限公司13393710386 · [email protected]
骓慕化学（天津）有限公司13116033143 17602663561 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…