Beta-Alanine
BETA-ALANINE · 3-AMINOPROPANOIC ACID · β-Ala · B-ALANINE · H-β-Ala-OH · BETA-ALA · Analine · 3-AMINOPROPIONIC ACID
Identifiers & Physical Properties
| CAS No. | 107-95-9 |
|---|---|
| Molecular formula | C3H7NO2 |
| Average molar mass | 89.09 g/mol |
| Monoisotopic mass | 89.04767847 g/mol |
| SMILES | NCCC(=O)O |
| InChIKey | UCMIRNVEIXFBKS-UHFFFAOYSA-N |
| PubChem CID | 239 |
| ChEMBL | CHEMBL297569 |
| ChEBI | CHEBI:16958 |
| EC No. | 203-536-5 |
| DTXSID | DTXSID0030823 |
Chemical & Physical Properties
| XLogP | -3 |
|---|---|
| Topological polar surface area | 63.3 |
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 2 |
| Heavy atoms | 6 |
| Formal charge | 0 |
| Complexity | 52 |
| LogP (partition coefficient) | -3.05 |
| Solubility | 545000545.0 mg/mLSoluble in waterInsoluble in ether and acetoneSlightly soluble (in ethanol)H2O: 1 M at 20 °C, clear, colorlessSoluble in water(550g/L). Slightly soluble in alcohol. Insoluble in ether and acetone. |
| Melting point | 200200 °C202 °C (dec.)(lit.) |
| Vapor pressure | 0.00000005 [mmHg] |
| Physical Description | Solid[Merck Index] White crystalline solid[Alfa Aesar MSDS]Colourless needles |
| Ionization Efficiency | Positive2.152.7Agilent XCTElectrospray ionizationformic acid (5.3nM) |
| Dissociation Constants | 10.23.63 (at 5 °C) |
| Boiling point | 237.1±23.0 °C(Predicted) |
| Bulk density | 770kg/m3 |
| Density | 1,437 g/cm3 |
| FLAVIS Number | 17.001 | beta-Alanine |
| Refractive index | 1.4650 (estimate) |
| FEMA | 3252 | BETA-ALANINE |
| Flash point | 204-206°C |
| Storage conditions | Keep in dark place,Inert atmosphere,Room temperature |
| pKa (acidity coefficient) | 3.55(at 25℃) |
| Physical state | Crystalline Powder |
| Color | White |
| pH | 6.0-7.5 |
| Odor | at 100.00 %. odorless |
| Odor type | odorless |
| Biological source | synthetic |
| Decomposition | 204-206 ºC |
| λmax | λ: 260 nm Amax: ≤0.02λ: 280 nm Amax: ≤0.02 |
| Merck | 14,205 |
| JECFA Number | 1418 |
| BRN | 906793 |
| Stability | Stable. Keep dry. |
| Cosmetics Ingredients Functions | HUMECTANT |
| InChI | 1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) |
| InChIKey | UCMIRNVEIXFBKS-UHFFFAOYSA-N |
| SMILES | NCCC(O)=O || NCCC(O)=O |
| LogP (partition coefficient) | -0.882 (est) |
| Substances Added to Food (formerly EAFUS) | BETA-ALANINE |
| CAS DataBase Reference | 107-95-9(CAS DataBase Reference) |
| FDA UNII | 11P2JDE17B |
| NIST Chemistry Reference | Beta-alanine(107-95-9) |
| EPA Substance Registry System | .beta.-Alanine (107-95-9) |
| UNSPSC Code | 85151701 |
| NACRES | NA.75 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P261-P305+P351+P338 |
| Personal protective equipment (PPE) | Eyeshields, Gloves, type N95 (US) |
| Hazard symbols | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 24/25-36-26 |
| Water hazard class (WGK) | 3 |
| RTECS number | UA2369200 |
| TSCA inventory status | TSCA listed |
| Customs code | 29224920 |
| Storage class | 11 - Combustible Solids |
| REACH registrations | Active |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 98.5% (322 of 327) of all reports.Not ClassifiedReported as not meeting GHS hazard criteria by 322 of 327 companies (only 1.5% companies provided GHS information). For more detailed information, please visit ECHA C&L website.Aggregated GHS information provided per 327 reports by companies from 5 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 322 of 327 reports by companies.There are 4 notifications provided by 5 of 327 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatory information | Chemical: .beta.-AlanineRegulation (EC) No 1831/2003 (amended)Status: Active Update: 02-12-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/2084Status: Active Update: 05-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/27826.beta.-Alanine: Does not have an individual approval but may be used under an appropriate group standard |
| Other safety information | Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment |
| Hazards summary | Safe when used as a flavoring agent in food[JECFA] May cause eye irritation[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Not Classified |
| Health effects | Chronically high levels of beta-alanine are associated with at least 2 inborn errors of metabolism including: GABA-Transaminase Deficiency and Methylmalonate Semialdehyde Dehydrogenase Deficiency. |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Personal protective equipment (PPE) | Eyeshields, Gloves, type N95 (US) |
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| RTECS number | UA2369200 |
| Customs code | 29224920 |
| Risk statements (R) | 36/37/38 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi |
| Safety statements (S) | 24/25-36-26 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H315-H319-H335 |
| REACH registrations | Active |
| GHS precautionary statements | P261-P305+P351+P338 |
Applications & Uses
Description
Beta-alanine is a non-proteogenic amino acid that is produced endogenously in the liver. In addition, humans acquire beta-alanine through the consumption of foods such as poultry and meat. By itself, the ergogenic properties of beta-alanine are limited; however, beta-alanine has been identified as the rate-limiting precursor to carnosine synthesis, and has been consistently shown to increase levels of carnosine in human skeletal muscle. Doses of 4 to 6 g/day of beta-alanine have been shown to increase muscle carnosine concentrations by up to 64 % after 4 weeks, and up to 80 % after 10 weeks. Baguet et al. demonstrated that individuals vary in the magnitude of response to 5 to 6 weeks of betaalanine supplementation (4.8 g/day), with high responders increasing muscle carnosine concentrations by an average of 55 %, and low responders increasing by an average of only 15 %. The difference between high and low responders seems, at least in part, to be related to baseline muscle carnosine content and muscle fiber composition. β-Alanine, a β−amino acid, is a component of pantothenic acid and the rate-limiting amino acid in the biosynthesis of the histidinyl antioxidant dipeptides carnosine and anserine. Endogenous β-amino acid that is a nonselective agonist at glycine receptors and a ligand for the G protein-coupled orphan receptor, TGR7 (MrgD). β-Alanine flux plays a cytoprotective role by supporting the osmotic stability of marine organisms, preimplantation mouse embryos and mammalian cells exposed to hypoxic stress.
Uses
It is widely used in medicine, feed, food, and other industries, mostly to synthesize pantothenic acid and calcium pantothenate (a medicine and feed additive), carnosine, pamidronate sodium, barley nitrogen. It is also used to produce plating corrosion inhibiter, as a biological reagent, and as an organic synthesis intermediate. Used as a food and health supplement additive. Endogenous beta-amino acids, non-selective glycine receptor agonists ，G-protein-coupled orphan receptor (TGR7, MrgD) ligand. Relying on the stability of marine biology, beta-aminopropionic acid has a protective effect on cells.
Description
β-Alanine (or beta-alanine) is a naturally occurring beta amino acid, which is an amino acid in which the amino group is at the β- position from the carboxylate group (i.e., two atoms away. The IUPAC name for β-alanine is 3-amino propanoic acid. Unlike its counterpart α-alanine, β-alanine has no stereocenter. β-Alanine is not used in the biosynthesis of any major proteins or enzymes. It is formed in vivo by the degradation of dihydrouracil and carnosine. It is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (vitamin B5), which itself is a component of coenzyme A. Under normal conditions, β-alanine is metabolized into acetic acid. β-Alanine is the rate-limiting precursor of carnosine, which is to say carnosine levels are limited by the amount of available β-alanine. Supplementation with β-alanine has been shown to increase the concentration of carnosine in muscles, decrease fatigue in athletes and increase total muscular work done.Typically, studies have used supplementing strategies of multiple doses of 400 mg or 800 mg, administered at regular intervals for up to eight hours, over periods ranging from 4 to 10 weeks . After a 10 - week supplementing strategy, the reported increase in intramuscular carnosine content was an average of 80.1% (range 18 to 205%).
Occurrence
Reported to occur as a component in amino acids; carnosine, anserine, pantothenic acid
Uses
Effective catalyst for the Knoevenagel condensation. Beta Alanine is used as nutrition supplements in food production. Increase muscular strength & power output, Increases Muscle Mass, increase Anaerobic Endurance.
Uses
β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine, as a result supplementation with β-alanine increases the concentration of carnosine in muscles.
Uses
β-Alanine has been used as a ligand for the orphan MAS-related receptor. It has also been used in culture media used for certain strains of yeast to test for β-alanine auxotrophy.
General Description
An N-blocked form of alanine.
Preparation & Synthesis
Preparation
Acrylonitrile and ammonia react in a solution of diphenylamine and t-butanol to create beta-aminopropionitrile, which is then alkalized to obtain beta-aminopropionic acid. In a dry autoclave, sequentially add acrylonitrile, diphenylamine and t- butanol, and stir for 5min. Then, add liquid ammonia, maintain the temperature at 100-109℃ and pressure at 1MPa, and stir for 4h. Cool to below 10℃ and stop mixing when the pressure reaches atmospheric pressure. At 65-70℃/(8.0-14.7kPa), decrease the pressure to recover t-butanol to obtain crude beta-aminopropionitrile. Distill the crude product under low pressure, collect the 66-105℃/（1.33-4.0kPa） distillation to obtain beta-aminopropionitrile, and maintain temperature for 1h. Steam under low pressure for half an hour to remove the ammonia in the reaction solution, add water, and drop in hydrochloric until PH reaches 7-7.2. Filter to remove trace impurities. Concentrate the filtered liquid until a large amount of solid precipitates, extract while hot and cool to below 10℃. Filter and vacuum dry to obtain beta-aminopropionic acid. This method requires 982kg beta-aminopropionitrile for every ton of product, and the yield of alkalization is 90%. Place the alkaline sodium hypochlorite solution obtained from degradation of succinimide (Hoc reaction) (containing 14% sodium hypochlorite, 8% sodium hydroxide, 30% sodium carbonate) and ice into a reaction chamber, mix and add succinimide, and let react at 18-25℃ for 0.5h. Increase temperature to 40-50℃ and allow to react for 1h. Add hydrochloric acid to adjust the PH to 4-5, decrease the pressure to condense. After condensed and cooled, add 3 times the amount of 95% ethanol to allow inorganic salts to precipitate, filter, and repeat once again. Then, dilute the filtered liquid with 4 times the amount of distilled water and reflux for 1h. Add activated charcoal to remove color, filter, and pass the filtered liquid through exchange resin. Add activated charcoal to remove color, filter, decrease pressure to condense, cool to crystalize, filter, use distilled water to recrystallize once, and obtain beta-aminopropionic acid. Hydrolyze and acidify beta-aminopropionitrile to obtain.
Preparation
By heating acrylic acid with concentrated aqueous ammonia under pressure, by addition of acrylonitrile to phthalimide or to ammonia; from β-aminopropionitrile, from succinimide by the Hofmann degradation.