Basic information
- CAS
23491-44-3- Standard SMILES
CN1CCN(c2ccc3nc(-c4ccc5nc(-c6ccc(O)cc6)[nH]c5c4)[nH]c3c2)CC1- InChIKey
INAAIJLSXJJHOZ-UHFFFAOYSA-N- Molecular formula
- C25H24N6O
- Average molar mass
- 424.5 g/mol
- Monoisotopic mass
- 424.20115941
Overview
Pibenzimol is a bibenzimidazole and a N-methylpiperazine. It has a role as an anthelminthic drug and a fluorochrome.
Names & identifiers
- Preferred name
- Bisbenzimidazole
- IUPAC
- 4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenol
- English name
- HOECHST 33258
- Molecular formula
- C25H24N6O
- Molecular weight
- 424.5
Names & synonyms
Pibenzimol23491-44-3BisbenzimidazoleHoe-33258LHQ7J5KV9BCHEBI:520824-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenolp-(5-(5-(4-Methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)phenolNSC322921SL-11063DTXSID3066899Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-
Show more names
BisbenzimidazolBISBENZIMIDE H 33258hoechst 33258 (bisbenzimide)CELLSTAIN- HOECHST 33258 SOLUTIONbis-benzimide (hydroxyphenyl form)BISBENZIMIDE TRIHYDROCHLORIDE HYDRATEbisbenzimide trihydrochloride cell*culture tested4-[6'-(4-Methylpiperazino)-6,2'-bi[1H-benzimidazole]-2-yl]phenol
NSC 3229214-[5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzimidazol-2'-yl]phenol4-(5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzimidazol-2'-yl)phenolPhenol, p-[5-[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]-2-benzimidazolyl]-RefChem:120360DTXCID60368814-(5-(5-(4-Methylpiperazin-1-yl)benzimidazol-2-yl)benzimidazol-2-yl)phenol245-689-0
Properties
Computed structural properties
- XLogP
- 4
- Topological polar surface area
- 84.1 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 3
- Heavy atoms
- 32
- Formal charge
- 0
- Complexity
- 634
Physicochemical properties
- Melting point
- 314 °C · 314 °C
- Boiling point
- 746.9 · 746.9±70.0 °C(Predicted)
- Density
- 1.355 · 1.355±0.06 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- solubility
- 2 O: · H2O: 10 mg/mL
- form
- powder
- pka
- 9.23 · 9.23±0.15(Predicted)
- color
- Light yellow to yellow
- Stability
- Stable. Incompatible with strong oxidizing agents. Light sensitive.
- FDA UNII
- 7 J5KV9B · LHQ7J5KV9B
- NCI Drug Dictionary
- pibenzimol
- EPA Substance Registry System
- 4 · Phenol, 4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]- (23491-44-3)
- Hazard Codes
- Xn
- Risk Statements
- 22 · 22-36/38
- Safety Statements
- 26 · 26-36
- WGK Germany
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- F
- 3-8-10
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- SM1140500
- risk_code
- 22-36/38
- hazard_code
- Xn
- safety_code
- 26-36
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Pharmacological agents destructive to nematodes in the superfamily Filarioidea.
Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Uses & manufacturing
General Manufacturing InformationPhenol, 4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-: INACTIVE
Applications
UsesHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].
Suppliers27 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
陕西科贝莱药物研发有限公司13119135307 13119135307 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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