1,4-Bis(maleimido)butane

HCID 239576

Notes Reactions

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Basic information

CAS: 28537-70-4
Standard SMILES: O=C1C=CC(=O)N1CCCCN1C(=O)C=CC1=O
InChIKey: WXXSHAKLDCERGU-UHFFFAOYSA-N
Molecular formula: C12H12N2O4
Average molar mass: 248.23 g/mol
Monoisotopic mass: 248.07970687

Names & identifiers

Preferred name: 1,4-Bis(maleimido)butane
IUPAC: 1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione
English name: 1,4-Bis-maleimidobutane
Molecular formula: C12H12N2O4
Molecular weight: 248.23

Names & synonyms

28537-70-41,4-Bis(maleimido)butaneDTXSID80286325RefChem:416459DTXCID00237475634-780-41,1'-(Butane-1,4-diyl)bis(1H-pyrrole-2,5-dione)1,4-BIS-MALEIMIDOBUTANE1H-Pyrrole-2,5-dione, 1,1'-(1,4-butanediyl)bis-1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dioneMFCD013183421,4-bismaleimidobutane

Show more names

NSC44747BMB CrosslinkerBis-MaleiMidobutane1,4-DI(MALEIMIDO)BUTANE1,4-BIS(MALEIMIDE)BUTANETetraMethylenediMaleiMideTetraMethylenebisMaleiMide1,4-Bis-MaleiMidobutane(BMB)

N,N'-TetramethylenebismaleimideTetramethylene-bismaleimideSCHEMBL155748CHEMBL567436AS-67288PD1351301-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butyl]-2,5-dihydro-1H-pyrrole-2,5-dioneBMB

Database identifiers

CAS: 28537-70-4
PubChem CID: 239576
DTXSID: DTXSID80286325
ChEMBL: CHEMBL567436
EC Number: 634-780-4
Nikkaji: J102.954A

Properties

Computed structural properties

XLogP: -0.5
Topological polar surface area: 74.8 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 4
Rotatable bonds: 5
Heavy atoms: 18
Formal charge: 0
Complexity: 398

Physicochemical properties

Melting point: 196 · 196-197°C
Boiling point: 450.3 · 450.3±28.0 °C(Predicted)
Density: 1.388 · 1.388±0.06 g/cm3(Predicted)
storage temp.: -20 °C · Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform
form: Solid
pka: -1.93 · -1.93±0.20(Predicted)
color: White to Off-White
Appearance: White solid
BRN: 1538100 · 1538100
InChI: InChI=1S/C12H12N2O4/c15-9-3-4-10(16)13(9)7-1-2-8-14-11(17)5-6-12(14)18/h3-6H,1-2,7-8H2
InChIKey: WXXSHAKLDCERGU-UHFFFAOYSA-N
SMILES: C(N1C(=O)C=CC1=O)CCCN1C(=O)C=CC1=O
UNSPSC Code: 12352200 · 12352200
NACRES: 21 · NA.21
Symbol(GHS): 7 · GHS07

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

wgk: 3
hs_code: 2922.49.8000
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-36
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338

Chemistry & industry

Applications

UsesA short, sulfhydryl reactive homobifunctional crosslinking reagent

Upstream & downstream products

Upstream raw materials

4,7-Epoxy-1H-isoindole-1,3(2H)-dione, 2-[4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-epoxy-2H-isoindol-2-yl)butyl]-3a,4,7,7a-tetrahydro-

Suppliers54 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]

上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

上海腾准生物科技有限公司19821570922 · [email protected]

Related reactions

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Compound notes

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