Basic information
- CAS
133052-90-1- Standard SMILES
CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21- InChIKey
QMGUOJYZJKLOLH-UHFFFAOYSA-N- Molecular formula
- C25H24N4O2
- Average molar mass
- 412.5 g/mol
- Monoisotopic mass
- 412.18992602
Overview
Bim-1 is a member of indoles.
Names & identifiers
- Preferred name
- 3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
- IUPAC
- 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
- English name
- GF109203X
- Molecular formula
- C25H24N4O2
- Molecular weight
- 412.48
Names & synonyms
bisindolylmaleimide i133052-90-13-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dioneL79H6N0V6C3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONEDTXSID501579322-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide2-(1-(3-Dimethylaminopropyl)indol-3-yl)-3-(indol-3-yl)maleimide3-[1-[3-(dimethylamino)propyl]-1h-indol-3-yl]-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione3-(1-(3-(dimethylamino)propyl)indol-3-yl)-4-(1H-indol-3-yl)pyrrole-2,5-dionebisindoylmaleimide I
Show more names
BISINDOLYLMALEIMIDEBIM 1G 6850]CS-1080EstorraGO 6850 HCLGF-109203X HCL
BIS-1 cpdRefChem:569459DTXCID3080423GF109203XGF 109203XGF-109203XGo 6850BIM-1
Properties
Computed structural properties
- XLogP
- 3.1
- Topological polar surface area
- 70.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 6
- Heavy atoms
- 31
- Formal charge
- 0
- Complexity
- 748
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Melting point
- 280 ℃ · 280℃ (decomposition)
- Boiling point
- 685.6 · 685.6±55.0 °C(Predicted)
- Density
- 1.3 · 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- 1 mg/mlsoluble · DMSO: ~1 mg/mlsoluble
- pka
- 8.13 · 8.13±0.60(Predicted)
- form
- Liquid
- color
- Orange
- biological source
- synthetic
- Water Solubility
- Insoluble in water.
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
- InChIKey
- QMGUOJYZJKLOLH-UHFFFAOYSA-N
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- 3
- rtecs
- UX9590000
- hs_code
- 2925199590
- risk_code
- 40-22
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- hazard_code
- Xn
- safety_code
- 36/37
- Storage Class
- 10 - Combustible liquids
- Hazard statements
- H350
- Precautionary statements
- P201-P202-P280-P308+P313-P405-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that reduce or suppress INFLAMMATION.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Applications
DescriptionGF-109203X (133052-90-1) is a potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 μM and phosphorylase kinase IC50 = 0.7 μM). Inactive against the tyrosine kinases EGFR, PGDFR and Insulin receptor. Potent inhibitor of GSK-3β in cell lysates (IC50 = 360nM) and GSK-3β immunoprecipitates (IC50 = 170nM) derived from rat epididymal adipocytes.2 Cell permeable.
UsesBisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
Related reactions
2 records
Compound notes
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