Basic information
- CAS
137592-45-1- Standard SMILES
CN1CCCC1CCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21- InChIKey
LBFDERUQORUFIN-UHFFFAOYSA-N- Molecular formula
- C27H26N4O2
- Average molar mass
- 438.5 g/mol
- Monoisotopic mass
- 438.20557608
Overview
protein kinase C inhibitor; see also bisindolylmaleimide I
Names & identifiers
- Preferred name
- bisindolylmaleimide II
- IUPAC
- 3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione
- English name
- BISINDOLYLMALEIMIDE II
- Molecular formula
- C27H26N4O2
- Molecular weight
- 438.52
Names & synonyms
bisindolylmaleimide ii137592-45-1DTXSID001314226RefChem:917326DTXCID0017440373-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dioneCHEMBL2183282-(1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3-yl-3-(1H-indol-3-yl)maleimide3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl -2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2 ,5-dioneBIM-2Bisindolyl deriv. 22
Show more names
(rac)-AR-13503Bisindolylmaleimide II, PKC inhibitor2-[1-[2-(1-METHYLPYRROLIDINO)ETHYL]-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-
Bisindolylmaleimide II, 98%BDBM2694orb1704659SCHEMBL7978085SCHEMBL293778812-(1-(2-(1-methylpyrrolidino)ethyl)-1H-indol-3-yl)maleimideEX-A14492HB0135
Properties
Computed structural properties
- XLogP
- 3.7
- Topological polar surface area
- 70.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 5
- Heavy atoms
- 33
- Formal charge
- 0
- Complexity
- 825
Physicochemical properties
- Boiling point
- 709.9 · 709.9±60.0 °C(Predicted)
- Density
- 1.36 · 1.36±0.1 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 8.17 · 8.17±0.60(Predicted)
- color
- Yellow to orange
- biological source
- synthetic (organic)
- InChIKey
- LBFDERUQORUFIN-UHFFFAOYSA-N
- SMILES
- CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26
- UNSPSC Code
- 12352111 · 12352111
- NACRES
- 77 · NA.77
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- WGK Germany
- 3 · 3
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesBisindolylmaleimide II, is a potent ATP-competitive protein kinase C (PKC) inhibitor. In addition it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM).
Suppliers13 total
Aladdin Scientific[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
EMMX Biotechnology LLC888-539-0666 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
BOC Sciences[email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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