1-((4-Methoxyanilino)methyl)-2-naphthol
Basic information
- CAS
6638-24-0- Standard SMILES
COc1ccc(NCc2c(O)ccc3ccccc23)cc1- InChIKey
IBZVGAKJSAZIAB-UHFFFAOYSA-N- Molecular formula
- C18H17NO2
- Average molar mass
- 279.3 g/mol
- Monoisotopic mass
- 279.12592879
Overview
a laminin receptor inhibitor; structure in first source
Names & identifiers
- Preferred name
- 1-((4-Methoxyanilino)methyl)-2-naphthol
- IUPAC
- 1-[(4-methoxyanilino)methyl]naphthalen-2-ol
- English name
- 2-(2,4-dichlorophenyl)-5-nitro-3H-benzoimidazole
- Molecular formula
- C18H17NO2
- Molecular weight
- 279.33
Names & synonyms
1-((4-methoxyanilino)methyl)-2-naphtholRefChem:907119NSC479246638-24-01-[(4-methoxyanilino)methyl]naphthalen-2-olNSC-47924CHEMBL12698451-(((4-Methoxyphenyl)amino)methyl)naphthalen-2-ol1-{[(4-methoxyphenyl)amino]methyl}naphthalen-2-olA1KEANCIStruc1_000437NCIStruc2_000383
Show more names
2-(2,4-dichlorophenyl)-5-nitro-3H-benzoimidazole
2-Naphthalenol, 1-[[(4-methoxyphenyl)amino]methyl]-orb1699804SCHEMBL8738476DTXSID90985019NCI47924BDBM50328820CCG-37714NCGC00013580
Database identifiers
- CAS
6638-24-0- PubChem CID
- 240945
- DTXSID
DTXSID90985019- ChEMBL
CHEMBL1269845- Nikkaji
- J2.341.159H
Properties
Computed structural properties
- XLogP
- 4.3
- Topological polar surface area
- 41.5 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 4
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 314
Physicochemical properties
- storage temp.
- -20 °C · -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
- form
- solid
- color
- Yellow
- Stability
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Chemistry & industry
Applications
DescriptionNSC-47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM (IC50=19.35 μM) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3
UsesNSC47924 is a laminin receptor (LR) inhibitor. NSC47924 affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein. NSC47924 can be used for testing prion diseases[1].
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Compound notes
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