Phosphorus trichloride

Spray cooling water on containers that are exposed to flames until well after fire is out. Do not get water inside containers.

NO hydrous agents. NO water. In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

Warning: Phosphorus trichloride is a corrosive agent. Contact with eyes may result in severe damage to the cornea, conjunctiva, and blood vessels. Caution is advised.

General First Aid:

(General first aid procedures)

The vapor is heavier than air ... A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

Severe health hazard. May be fatal if inhaled ... Corrosive ...

Reacts violently with fire extinguishing agents such as water ... Reacts violently with water producing heat and decomposition products including hydrochloric acid and phosphorous acid, causing fire and explosion hazard.

· Wear positive pressure self-contained breathing apparatus (SCBA).

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

0.1 [ppm]

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame - consider evacuation of one-third (1/3) mile radius.

If material on fire or involved in fire: Use dry chemical, dry sand, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantites of water. Apply water from as far a distance as possible.

... Use water spray to knock down acid vapors.

NO hydrous agents. NO water ...

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. Dry. Well closed. Ventilation along the floor.

Store in cool, dry, well-ventilated location. Separate from acids, alkalies, organics, alkali metals.

Environmental considerations: water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaCO3). Use mechanical dredges or lifts to remove immobilized masses of pollutant and precipitates. Adjust pH to neutral (pH=7).

Environmental considerations: air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.

Environmental considerations: land spill: Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3).

Releases may require isolation or evacuation. Use water spray to cool and disperse vapors and protect personnel.

For more Cleanup Methods (Complete) data for PHOSPHORUS TRICHLORIDE (6 total), please visit the HSDB record page.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Spillage should be handled only by an operator wearing full protective clothing and full-face mask/positive-pressure breathing apparatus. Absorbed spillage and residues should be buried in an approved landfill, away from water sources.

The substance can be absorbed into the body by inhalation and by ingestion.

inhalation, ingestion, skin and/or eye contact

/AQUATIC SPECIES/ LC100s /of phosphorus trichloride are/ 57 mg/L/7 days /for/ sturgeon /and/ 65 mg/L/48 hr /for/ sturgeon (Acipenser), carp (Cyprinus carpio), perch (Percidae), Esox lucius (northern pike), and Leuciscus leuciscus (dace). NOEC /at/ pH 3.3 to 7.0 /and/ 22 to 24 °C /is/ 10 to 40 mg/L/30 days /for/ sturgeon, carp, perch, Esox lucius and Leuciscus leuciscus.

/AQUATIC SPECIES/ Aquatic toxicity range: 10 to 100 mg/L.

Sore throat. Cough. Burning sensation. Nausea. Vomiting. Shortness of breath. Laboured breathing. Symptoms may be delayed.

Pain. Redness. Blisters. Skin burns.

Pain. Redness. Watering of the eyes. Severe deep burns. Loss of vision.

Burning sensation. Abdominal pain. Shock or collapse. Further see Inhalation.

irritation eyes, skin, nose, throat; pulmonary edema; eye, skin burns

/SIGNS AND SYMPTOMS/ The signs of poisoning in 23 workers exposed to phosphorus trichloride at concentrations ranging from 1.8 to 27 ppm. Symptoms included burning eyes and throat, irritation of pharyngeal mucous membranes, and mild bronchitis; these changes occurred within 2 to 6 hours after exposure. Symptoms from subacute poisoning included irritation of the pharynx, coughing, dyspnea, and severe asthmatic bronchitis, which occurred 1 to 8 weeks after exposure. In workers who had at least 1 year exposure, emphysema was sometimes found. Both acute and subacute poisonings were frequently accompanied by fever and moderate leukocytosis and neutrophilia.

/SIGNS AND SYMPTOMS/ ... The corrosive effect /of phosphorus trichloride/ is complete destruction of skin or mucous membrane. /From table/

/SIGNS AND SYMPTOMS/ In a report of 17 persons exposed to phosphorus trichloride and its hydration products, those closest to the spill experienced burning eyes, lacrimation, nausea, vomiting, dyspnea, and cough. Pulmonary function tests showed decrements in vital capacity, maximal breathing capacity, and forced expiratory volume in direct correlation to the distance from the accident.

/SIGNS AND SYMPTOMS/ Phosphorus trichloride will cause severe burns upon direct dermal contact.

For more Human Toxicity Excerpts (Complete) data for PHOSPHORUS TRICHLORIDE (13 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ /In/ rabbits /on contact of phosphorus trichloride caused/ thickening in skin folds, bleeding /and/ irreversible necrosis in the eye, causing loss of vision.[European Chemicals Bureau; IUCLID Dataset, Phosphorus trichloride (7719-12-2) (2000 CD-ROM edition). Available from, as of November 03, 2006: http://esis.jrc.ec.europa.eu/]

/LABORATORY ANIMALS: Acute Exposure/ Cats and rabbits /were exposed to phosphorus trichloride by/ inhalation. At 0.004 mg/L for 6 hr minor symptoms /were seen/. With 0.01 to 0.02 mg/L no serious symptoms within 1 hr, 0.3 to 0.5 mg/L serious destructions within the first hour /were seen/. With 0.8 mg/L mortality /occurred/ within 5 to 36 hr, with 3.5 mg/L within 3 hr. Effects /included/ salivation, rhinitis, dyspnea, conjunctivitis, corneal opacities, edema of the respiratory tract.[European Chemicals Bureau; IUCLID Dataset, Phosphorus trichloride (7719-12-2) (2000 CD-ROM edition). Available from, as of November 03, 2006: http://esis.jrc.ec.europa.eu/]

/LABORATORY ANIMALS: Acute Exposure/ ... Working with cats & guinea pigs /investigators/ found that a concentration of 0.7 ppm produced only slight illness in 6 hr. 2 to 4 ppm did not produce severe symptoms in 1 hr, but serious disturbances resulted from 1 hr at 50 to 90 ppm. Effects of phosphorous trichloride were considered 5 to 10 times as intense as would result from hydrogen chloride produced by hydrolysis.[American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's with Other World Wide Occupational Exposure Values. CD-ROM Cincinnati, OH 45240-1634 2005., p. 1]

/LABORATORY ANIMALS: Acute Exposure/ Expt in cats concn of 2 to 4 ppm in air in course of 6 hr has caused resp difficulty and conjunctivitis. At 23 to 90 ppm in air in course of 6 hr corneas became clouded and systemic effects were severe.[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 736]

For more Non-Human Toxicity Excerpts (Complete) data for PHOSPHORUS TRICHLORIDE (14 total), please visit the HSDB record page.

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Chlorine and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Chlorine and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Administer activated charcoal ... . If product was ingested, protect yourself from contact with vomitus as it may cause burns. /Phosphorus and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose stick or glucometer readings below 50 mg/dl) and administer 50% dextrose if necessary. Draw blood sample before administration ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Phosphorus and related compounds/

LD50 Rat oral 550 mg/kg

LC50 Rat inhalation 104 ppm/4 hr

LC50 Rat Inhalation 0.592 mg/L/4 hr

LC50 Rat inhalation 584 mg/cu m/4 hr

For more Non-Human Toxicity Values (Complete) data for PHOSPHORUS TRICHLORIDE (7 total), please visit the HSDB record page.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Phosphorus trichloride is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1,000 lbs.

Phosphorus trichloride is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Phosphorus trichloride

1

15000

3.48

45

A Commercial Grade