Copper sulfate pentahydrate

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

In case of fire in the surroundings, use appropriate extinguishing media.

Fresh air, rest.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Environmental concerns - land spill: Dig a pit, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /Cupric sulfate/

Environmental concerns - water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH= 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Cupric sulfate/

Add slowly to a large container of water. Stir in slight excess of soda ash. Let stand for 24 hr. Decant or siphon into another container & neutralize with 6 molar hydrochloric acid before washing down drain with large excess of water. The sludge may be added to landfill.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Add slowly to a large container of water. Stir in slight excess of soda ash. Let stand for 24 hr. Decant or siphon into another container and neutralize with 6 M HCl before washing down drain with large excess of water. The sludge may be added to landfill. Recommendable methods: Precipitation, solidification, & landfill. Peer-review: Precipitate with calcium hydroxide. Dilute supernatant and discharge to sewer. Copper can be recovered by cation exchange. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance, protective gloves, protective clothing and safety goggles. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.

Personnel protection: Keep upwind. ... Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Cupric sulfate/

If material not involved in fire: Keep material out of water sources & sewers. Build dikes to contain flow as necessary. /Cupric sulfate/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

The milk of female vineyard workers, who were exposed to copper sulfate and a variety of other pesticides, contained 6.2 times as much copper as the milk of milkmaids who did equally hard work but not exposed to pesticides. Placentas from the vineyard workers contained 4.7 times more copper than those from milkmaids. ... Copper ... occurs in all tissues. ... The concn in blood, muscle, and most of the viscera range from 0.85 to 1.90 ppm. Values for plasma lie in the narrow range of 1.16 to 1.42 ppm. The concn in the brain (2.2 to 6.8 ppm), liver (7.1 ppm in adults and 24 ppm in infants), and bone (3.7 to 4.7 ppm in rib and 6.8 ppm in long bones) are higher.

MAY CAUSE DRAMATIC INCR IN MORTALITY OF TURKEYS GIVEN BLACKHEAD CONTROL DRUGS CONTAINING ARSENIC & EXPOSED TO BLACKHEAD.

COPPER SULFATE POTENTIATED IRRITANT RESPONSE TO SULFUR DIOXIDE IN GUINEA PIGS EXPOSED 1 HR TO AEROSOL.

IP INJECTION OF 5-10 MG/KG COPPER SULFATE PENTAHYDRATE & 25-90 MG/KG ETHYLNITROSOUREA INTO RATS CAUSED LOCAL ASCITES SARCOMAS AFTER 190 DAYS. INJECTION OF THE LATTER ALONE OR METAL SALTS ALONE HAD NO CARCINOGENIC EFFECT. SC ADMIN OF 10 MG/KG/WK ETHYLNITROSOUREA WITH 1 MG/KG COPPER SULFATE PENTAHYDRATE INDUCED LOCAL SARCOMAS IN 4 OF 24 ANIMALS TESTED.

LC50 LEPOMIS MACHOCHIRUS (BLUEGILL), WT 1.5 G, 884 UG/L @ 18 °C, STATIC BIOASSAY (95% CONFIDENCE LIMIT 707-1,100 UG/L) /TECHNICAL MATERIAL, 100% (ABOUT 25% ELEMENTAL COPPER)/

LC50 LEPOMIS CYANELLUS (GREEN SUNFISH), WT 1.1 G, 3,510 UG/L @ 18 °C, STATIC BIOASSAY (95% CONFIDENCE LIMIT 2,570-4,800 UG/L) /TECHNICAL MATERIAL, 100% (ABOUT 25% ELEMENTAL COPPER)/

LC50 PIMEPHALES PROMELAS (FATHEAD MINNOW), WT 1.2 G, 838 UG/L @ 18 °C (272 PPM CACO3), STATIC BIOASSAY (95% CONFIDENCE LIMIT 623-1,000 UG/L) /TECHNICAL MATERIAL, 100% (ABOUT 25% ELEMENTAL COPPER)/

LC50 CARASSIUS AURATUS (GOLDFISH), WT 0.9 G, 1,380 UG/L @ 18 °C (272 PPM CACO3), STATIC BIOASSAY (95% CONFIDENCE LIMIT 989-1,930 UG/L) /TECHNICAL MATERIAL, 100% (ABOUT 25% ELEMENTAL COPPER)/

For more Ecotoxicity Values (Complete) data for COPPER(II) SULFATE, PENTAHYDRATE (11 total), please visit the HSDB record page.

IT IS MORE PROBABLE THAT CONTAMINATION PERSISTS FOR LONGER THAN IS GENERALLY THOUGHT POSSIBLE; AFTER 5 MO, GRASS, WHICH HAD BEEN SPRAYED WITH COPPER SULFATE AS A MOLLUSCICIDE IN LIVER FLUKE CONTROL, STILL CONTAINED 200 PPM OF COPPER.

Absorbed by alga. Low foliar absorption on other vegetation. ... Both foliar & soil absorbed copper ions are translocated throughout the plant. Plant roots exclude the absorption of excess copper levels.

Cough. Sore throat.

Redness. Pain. Blurred vision. Burns.

Abdominal pain. Burning sensation. Nausea. Vomiting. Diarrhoea. Shock or collapse.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=7758-99-8]

The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. Bioaccumulation of this chemical may occur along the food chain, for example in fish. It is strongly advised not to let the chemical enter into the environment.

A report of 11 patients who had ingested an estimated 1 to 50 g of copper sulfate: they suffered nausea & vomiting, with epigastric pain in 5, diarrhea in 5, hypotension in 2, hematemesis or melena in 10, pallor in 10, jaundice in 8, delirium in 3, & coma in 2. All had intravascular hemolysis & developed oliguria or anuria. Five patients died despite gastric lavage, intravenous fluids, mannitol, diuretics, and dialysis. /Copper sulfate/

... COPPER SULFATE, KNOWN AS BLUESTONE OR BLUE VITRIOL, /WHEN USED WITH MISGUIDED OR SUICIDAL INTENT/ IS GENERALLY INGESTED IN GRAM QUANTITIES. NAUSEA, VOMITING, DIARRHEA, SWEATING, RARELY CONVULSIONS, COMA, & DEATH MAY RESULT.

A ... NUMBER OF CASES OF ACUTE POISONING IN MAN FROM INGESTING COPPER SULFATE, SOME OF THEM FATAL, HAVE BEEN REPORTED ... FROM NEW DELHI ... THE REPORT CONCERNS 48 HOSPITALIZED PATIENTS & 5 AUTOPSY CASES, 2/3 MALE, MOSTLY BETWEEN THE AGES OF 16 & 25 YR. DOSAGE ESTIMATES RANGED FROM 1 TO 12 G ... SWALLOWED IN WATER. SYMPTOMS ... WERE ... METALLIC TASTE, BURNING IN EPIGASTRIUM, & REPEATED VOMITING. IN MORE SEVERE CASES, DIARRHEA (14 PATIENTS) APPEARED ON THE FIRST OR SECOND DAY & LASTED 24 HR; 20 ... SHOWED BLOOD IN GI TRACT FROM INJURY TO GASTRIC MUCOSA, LEADING TO ULCERATION IN SEVERE CASES. SUPPRESSION OF URINE FOLLOWED JAUNDICE ... LIVER BIOPSY SHOWED CENTRILOBULAR NECROSIS & BILIARY STASIS. HYPERTENSION LEADING TO SHOCK ... CONSIDERED A BAD PROGNOSTIC SIGN: 3 OF 4 DIED. COMA DEVELOPED IN 4, PRESUMABLY DUE TO UREMIA FROM RENAL INJURY, & DEATHS OCCURRED IN 7 (14.6%). /COPPER SULFATE/

A CHILD, IN WHOM COPPER SULFATE CRYSTALS WERE APPLIED THERAPEUTICALLY TO SEVERELY BURNED SKIN SEVEN TIMES DURING NINE WK, DEVELOPED SEVERE ANEMIA. AFTER LAST TREATMENT, HEMOLYTIC CRISIS WITH ICTERUS TOOK PLACE. HIGH LEVELS OF COPPER IN SERUM & URINE ... INDICATED THAT ABSORPTION ... FROM THE WOUND DRESSING WAS RESPONSIBLE. /COPPER SULFATE/

For more Human Toxicity Excerpts (Complete) data for COPPER(II) SULFATE, PENTAHYDRATE (6 total), please visit the HSDB record page.

Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added are levels consistent with good feeding practice. Element: Copper; Source compound: copper sulfate. (All substances listed may be in anhydrous or hydrated form.)