Zinc Phosphate

HCID 24519CAS 13847-22-8

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Basic information

Standard SMILES: O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Zn+2].[Zn+2].[Zn+2]
InChIKey: LRXTYHSAJDENHV-UHFFFAOYSA-H
Molecular formula: Zn3-(P-O4)2
Average molar mass: 386.1 g/mol
Monoisotopic mass: 381.69426682

Overview

The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Phosphate...

Names & identifiers

Preferred name: Zinc Phosphate
IUPAC: trizinc diphosphate
English name: phosphoric acid, zinc salt
Molecular formula: H3O4P.xZn
Molecular weight: 0

Names & synonyms

Zinc Phosphate7779-90-0Trizinc diphosphateZinc orthophosphateDelaphosTrizinc phosphateTribasic zinc phosphateDelaphos 2MBonderite 40Granodine 80Microphos 90Granodine 16NC

Show more names

Einecs 237-583-8Phosphoric acid/zinc,(1:x) salt

Bonderite 181Bonderite 880Zinc acid phosphateHeucophos ZP 10Phosphinox PZ 06Sicor ZNP/MSicor ZNP/SVirchem 931

Database identifiers

CAS: 13847-22-8、14332-60-6、7779-90-0
PubChem CID: 24519
DTXSID: DTXSID3064807
ChEMBL: CHEMBL2286756
UNII: 1E2MCT2M62
EC Number: 231-944-3、237-583-8

Properties

Computed structural properties

Topological polar surface area: 173 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 8
Rotatable bonds: 0
Heavy atoms: 13
Formal charge: 0
Complexity: 36.8

Experimental & physicochemical properties

Chemical Classes · 2 items

Metals -> Phosphates, Metallic Salts

Metals -> Metals, Inorganic Compounds

CosmeticsCosmetic ingredients (Zinc Phosphate) -> CIR (Cosmetic Ingredient Review)

Density4 @25 °C

Melting Point900 °C

Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Physical Description · 2 items

Liquid; Other Solid; Dry Powder; Liquid; Liquid; CBI; Wet Solid; Dry Powder

White solid; [Hawley] White odorless powder; [MSDSonline]

Physicochemical properties

EPA Substance Registry System: Phosphoric acid, zinc salt (13847-22-8)
Symbol(GHS): 9 · GHS09
Signal word: Warning
Hazard statements: 410 · H410-H400
Precautionary statements: 273 · P273-P391-P501-P273-P391-P501
TSCA: TSCA listed

Safety & regulation

GHS classification

GHS Classification · 6 items

Warning

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P273, P391, and P501 (click each P-code to see the statement)

Warning

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P273, P391, and P501 (click each P-code to see the statement)

Hazard information

Regulatory Information · 5 items

Chemical: Phosphoric acid, zinc salt (2:3)

Chemical: Phosphoric acid, zinc salt

Phosphoric acid, zinc salt (2:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, zinc salt (2:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 31-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14696

Phosphoric acid, zinc salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Phosphoric acid, zinc salt (2:3): Human health tier I assessment

Hazards Summary · 2 items

Powder may cause eye irritation; [MSDSonline] Oral LD50 (rat) >5000 mg/kg; [Ullmann] See Zinc.

See Zinc.

Hazard Classes and Categories · 6 items

Not Classified

Aquatic Acute 1 (100%)

Hazardous to the aquatic environment (acute) - category 1

Hazardous to the aquatic environment (Acute) - Category 1

Reproductive toxicity - Category 2

Aquatic Acute 1

Safety & protection

Exposure Control and Personal Protection · 2 items

0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction)-for Zn inorg. compds[German Research Foundation (DFG)]

0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction) for Zn inorg. cmpnds[German Research Foundation (DFG)]

Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134)

Protective Action Criteria (PAC) · 3 items

1.8 [mg/m3]

20 [mg/m3]

120 [mg/m3]

Toxicology

TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)

Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

Exposure RoutesInhalation (L49) ; oral (L49) ; dermal (L49)

Toxicity Summary · 3 items

Safe for use in cosmetics, with qualifications

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Signs and Symptoms · 1 item

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Safety data

tsca: TSCA listed
Signal word: Warning
Symbol(GHS): GHS09
Hazard statements: H410-H400
Precautionary statements: P273-P391-P501-P273-P391-P501

Chemistry & industry

Pharmacology

Metabolism/Metabolites · 1 item

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

Uses & manufacturing

Uses · 4 items

CIR ingredient: Zinc Phosphate

Used in dental cements, phosphors, and coatings of steel and aluminum; [Hawley] The most important phosphate-containing pigment--reacts with iron to produce a protective film; [Ullmann]

Aluminum Producing [Category: Industry]

Zinc phosphate is used as a dental cement and corrosion resistant coating. (L74)

U.S. Production2023: 8,500,000 - <10,000,000 lb

Consumer UsesCorrosion inhibitor

Industry UsesStabilizing agent

Household ProductsInformation on 11 consumer products that contain Zinc phosphate in the following categories is provided:

General Manufacturing Information · 3 items

Miscellaneous Manufacturing

Phosphoric acid, zinc salt (2:3): ACTIVE

Phosphoric acid, zinc salt (1:?): ACTIVE