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Zinc ammonium sulfate

HCID 24539
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Basic information

CAS
7783-24-6
Standard SMILES
O.O.O.O.O.O.O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[NH4+].[NH4+].[Zn+2]
InChIKey
TXGQALXWGNPMKD-UHFFFAOYSA-L
Molecular formula
H20N2O14S2Zn
Average molar mass
401.7 g/mol
Monoisotopic mass
399.964737

Overview

Zinc ammonium sulfate is a sulfate of zinc and ammonium. Zinc is a metallic element with the atomic number 30. It is found in nature most often as the mineral sphalerite. Though excess zinc in harmful, in smaller amounts it is an essential element for life, as it is a cofactor for over 300 enzymes and is found in just as many transcription factors. (L48, L49)

Names & identifiers

Preferred name
Zinc ammonium sulfate
IUPAC
diazanium;zinc;disulfate;hexahydrate

Names & synonyms

Ammonium zinc sulfateDiammonium zinc disulfate hexahydrateF20U770J8G7783-24-6Ammonium zinc sulfate hexahydrateZinc diammonium disulfate hexahydrateSulfuric acid, ammonium zinc salt (2:2:1), hexahydrateRefChem:195989dizinc(2+) ion diammonium disulfate237-483-4Zinc ammonium sulfateUNII-F20U770J8G
Show more names
HSDB 1044ZINC AMMONIUM SULFATE [HSDB]DIAMMONIUM ZINC SULFATE HEXAHYDRATEQ27277524AMMONIUM ZINC SULFATE ((NH4)2ZN(SO4)2) HEXAHYDRATE

Database identifiers

CAS
7783-24-6
PubChem CID
24539
UNII
F20U770J8G

Properties

Computed structural properties

Topological polar surface area
185 Ų
Hydrogen bond donors
8
Hydrogen bond acceptors
14
Rotatable bonds
0
Heavy atoms
19
Formal charge
0
Complexity
62.2

Experimental & physicochemical properties

Chemical ClassesMetals -> Metals, Inorganic Compounds
Density1.931
Color/FormWHITE MONOCLINIC CRYSTALS
SolubilitySOLUBILITY (G/100 CC WATER): 7 G @ 0 °C, 42 G @ 80 °C /ANHYDROUS/
Refractive IndexINDEX OF REFRACTION: 1.489, 1.493, 1.499
Physical DescriptionWhite solid; [HSDB]
Other Experimental PropertiesDECOMP BEFORE REACHING MP

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

Hazard information

Hazards SummaryIn laboratory experiments (dogs), 1 mg IV produced no adverse effects, while 100 mg IV caused hypotension, hypoxemia, and metabolic acidosis; No effects on human volunteers after short-term inhalation of aerosol; [HSDB] See Zinc.
Special Reports · 5 items

Zinc and Health. Current Bibliographies in Medicine 98-3. Public Services Division/National Library of Medicine. 3619 citations January, 1990-June, 1998. Available from: http://www.nlm.nih.gov/archive/20040831/pubs/cbm/zinc.html as of November 2, 1998.

USEPA; Ambient Water Quality Criteria Doc: Zinc (1980) EPA 400/5-80-079

USEPA; Ambient Water Quality Criteria Doc: Zinc (1987) EPA 400/5-87-003

Arvidson, B. A Review of Axonal Transport of Metals. Toxicology 88: 1-14 (19994) Recent findings regarding axonal transport of metals, including zinc.

For more Special Reports (Complete) data for ZINC AMMONIUM SULFATE (6 total), please visit the HSDB record page.

Clean Water Act Requirements · 3 items

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc and compounds/

For total recoverable zinc the criterion to protect freshwater aquatic life ... is 47 ng/l as a 24 hr average ... at hardnesses of 50, 100, and 200 mg/l as CaCO3 the concentration of total recoverable zinc should not exceed 180, 320, 570 ug/l at any time. /Soluble zinc salts/

For total recoverable zinc the criterion to protect saltwater aquatic life ... is 58 ug/l as a 24 hr average and the concentration should not exceed 170 ug/l at any time. /Soluble zinc salts/

State Drinking Water Guidelines · 2 items

(AZ) ARIZONA 5000 ug/l /Zinc/

(MN) MINNESOTA 2000 ug/l /Zinc/

Federal Drinking Water Guidelines · 2 items

EPA 5000 ug/l /Zinc/

EPA 2000 ug/l /Zinc, Lifetime health advisory/

Chemistry & industry

Pharmacology

Metabolism/Metabolites · 1 item

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

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Compound notes

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On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes

Safety & protection

Exposure Control and Personal Protection0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction) for Zn inorg. cmpnds[German Research Foundation (DFG)]
Disposal Methods · 1 item

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134)

Toxicology

TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)
InteractionsISOPROTERENOL PREVENTED /RESPIRATORY/ CHANGES, SUGGESTING THAT THEY WERE DUE TO SMOOTH MUSCLE CONTRACTION.
Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)
Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Exposure RoutesOral (L49) ; inhalation (L49) ; dermal (L49)
Toxicity Summary · 1 item

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Signs and Symptoms · 1 item

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Human Toxicity Excerpts · 3 items

HUMAN RESP RESPONSES TO AN AEROSOL CONTAINING ZINC AMMONIUM SULFATE PRODUCED MINIMAL OR NO SHORT-TERM RESPIRATORY EFFECTS.

PROLONGED EXPOSURE TO HIGH CONCN SHOULD BE CAREFULLY MONITORED BECAUSE OF POSSIBILITY THAT LOWER LEVELS IN BLOODSTREAM FOR LONG TIME PERIOD MIGHT HAVE ADVERSE CARDIOPULMONARY EFFECTS.

... A DISTINCT SYNDROME OF SYSTEMIC AMMONIA INTOXICATION IS RECOGNIZED IN ... MAN ... IN AN EXPERIMENTAL CONTEXT. ONLY REMOTE POSSIBILITY EXISTS ... THAT IT MIGHT OCCUR ... AS RESULT OF INGESTING ... AMMONIUM SALTS, EXCEPT IN PERSONS WITH PREEXISTING LIVER DISEASE. /AMMONIUM SALTS/

Artificial Pollution SourcesA COMPONENT OF ACID RAIN.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Non-Human Toxicity Excerpts · 5 items

IRRITANT POTENCY ... WAS STUDIED AT 4 PARTICLE SIZES, FROM 0.29-0.4 UM AT CONCN FROM 0.25-3.6 MG/CU M. ... ALL CONCN TESTED PRODUCED INCREASE IN /PULMONARY/ FLOW RESISTANCE IN GUINEA PIGS. IRRITANT POTENCY INCREASED AS PARTICLE SIZE DECREASED ... .

... ZINC AMMONIUM SULFATE PRODUCED RESPONSE SIMILAR TO, BUT LESSER IN DEGREE THAN, THAT PRODUCED BY HISTAMINE. EXPT WERE MADE ON ANESTHETIZED CATS ... 3 MIN INHALATION OF /SUBMICRON AEROSOL PARTICLES AT CONCN OF 40 TO 50 MG/CU M/ INCR PULMONARY RESISTANCE, DECR COMPLIANCE & INCR END EXPIRATORY TRANSPULMONARY PRESSURE.

... AFTER RAPID DEEP FREEZING OF LUNG IN OPEN THORAX PRINCIPAL SITES OF CONSTRICTION WERE ALVEOLAR DUCTS & TERMINAL BRONCHIOLES. BRONCHI & BRONCHIOLES LARGER THAN 400 UM WERE NOT CONSTRICTED. PHYSIOLOGIC RESPONSE & ANATOMIC DATA COMBINE TO INDICATE LOCUS OF ACTION OF SUBMICRON PARTICLES.

IM INJECTIONS OF 100 UG/KG BODY WT INTO INTACT & CASTRATED WHITE LEGHORN (14 WK OLD) ONCE DAILY FOR 4 WK DECR TESTES WT, INHIBITED SPERMATOGENESIS & DISTURBED TESTICULAR HORMONE PRODN; PITUITARY GONADOTROPHIC CELLS & ADRENALS SHOWED SIGNS OF ACTIVATION IN NONCASTRATED ONLY.

For more Non-Human Toxicity Excerpts (Complete) data for ZINC AMMONIUM SULFATE (8 total), please visit the HSDB record page.

Populations at Special Risk · 1 item

... A DISTINCT SYNDROME OF SYSTEMIC AMMONIA INTOXICATION IS RECOGNIZED IN ... MAN ... IN AN EXPERIMENTAL CONTEXT. ONLY REMOTE POSSIBILITY EXISTS ... THAT IT MIGHT OCCUR ... AS RESULT OF INGESTING ... AMMONIUM SALTS, EXCEPT IN PERSONS WITH PREEXISTING LIVER DISEASE. /AMMONIUM SALTS/

Regulatory information

Clean Water Act Requirements · 3 items

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc and compounds/

For total recoverable zinc the criterion to protect freshwater aquatic life ... is 47 ng/l as a 24 hr average ... at hardnesses of 50, 100, and 200 mg/l as CaCO3 the concentration of total recoverable zinc should not exceed 180, 320, 570 ug/l at any time. /Soluble zinc salts/

For total recoverable zinc the criterion to protect saltwater aquatic life ... is 58 ug/l as a 24 hr average and the concentration should not exceed 170 ug/l at any time. /Soluble zinc salts/

State Drinking Water Guidelines · 2 items

(AZ) ARIZONA 5000 ug/l /Zinc/

(MN) MINNESOTA 2000 ug/l /Zinc/

Federal Drinking Water Guidelines · 2 items

EPA 5000 ug/l /Zinc/

EPA 2000 ug/l /Zinc, Lifetime health advisory/