Budralazine

HCID 2463CAS 36798-79-5
Substructure searchFind similar structures

Basic information

Standard SMILES
CC(C)=CC(C)=NNc1nncc2ccccc12
InChIKey
DQGFCLJXYFXXIJ-UHFFFAOYSA-N
Molecular formula
C14H16N4
Average molar mass
240.3 g/mol
Monoisotopic mass
240.13749653

Names & identifiers

Preferred name
Budralazine
IUPAC
N-(4-methylpent-3-en-2-ylideneamino)phthalazin-1-amine
English name
Budralazine
Molecular formula
C14H16N4
Molecular weight
240.3

Names & synonyms

Buterazine36798-79-5BudralazinaBudralazinumS0177QHV2B1-(2-(1,3-Dimethyl-2-butenylidene)hydrazino)phthalazineDJ-14614-Methyl-3-penten-2-one (1-phthalazinyl)hydrazone1(2H)-Phthalazinone, (1,3-dimethyl-2-butenylidene)hydrazoneRefChem:917692Budralazine1-[2-(4-methylpent-3-en-2-ylidene)hydrazin-1-yl]phthalazine
Show more names
PTLZButrazine1,2H-PHTHALAZONEDIHYDROOXOPHTHALAZINEBudralazine USP/EP/BP1,2-DIHYDROPHTHALAZIN-1-ONE1,3-DIHYDRO-4-KETO-2 3-BENZODIAZINE
Budralazine [INN:JAN]Budralazinum [INN-Latin]Budralazina [INN-Spanish]DJ 14611-(2-(4-Methylpent-3-en-2-ylidene)hydrazinyl)phthalazine1-[2-(4-Methylpent-3-en-2-ylidene)hydrazinyl]phthalazineUNII-S0177QHV2BDTXSID00865833

Database identifiers

CAS
36798-79-5
PubChem CID
2463
DTXSID
DTXSID00865833
ChEMBL
CHEMBL2107516
UNII
S0177QHV2B

Properties

Computed structural properties

XLogP
3.1
Topological polar surface area
50.2 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
4
Rotatable bonds
3
Heavy atoms
18

Physicochemical properties

Melting point
183 · 183-185 °C(lit.)
Boiling point
373.02 °C · 373.02°C (rough estimate)
Density
1.1506 · 1.1506 (rough estimate)
refractive index
1.6 · 1.6000 (estimate)
storage temp.
-20 °C · Amber Vial, -20°C Freezer, Under inert atmosphere
solubility
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

Safety & regulation

Safety data

wgk
3
rtecs
TH9185000
Toxicity
LD50 in mice, rats (mg/kg): 1820, 620 orally; 4020, 3570 i.p. (Onodera)
risk_code
22
hazard_code
Xn
safety_code
22-24/25

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 2 items

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Drugs used to cause dilation of the blood vessels.

Applications

DescriptionBudralazine is an antihypertensive agent which is somewhat less potent than structurally related hydralazine, and reportedly produces less tachycardia.

UsesBudralazine a new antihypertensive agent. Budralazine is a direct-acting vasodilator.

Upstream & downstream products

Suppliers17 total

合肥翰刚医药科技有限公司+8618062405514 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]
陕西麟邦实业有限公司17709134430 · [email protected]

Additional notes

DefinitionChEBI: Budralazine is a member of phthalazines.

Related reactions

1 records
New reaction record

Linked notes

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