Basic information
- CAS
107-51-7- Standard SMILES
C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C- InChIKey
CXQXSVUQTKDNFP-UHFFFAOYSA-N- Molecular formula
- C8H24O2Si3
- Average molar mass
- 236.53 g/mol
- Monoisotopic mass
- 236.10840961
Overview
Octamethyltrisiloxane is an organosiloxane that is trisiloxane in which all the hydrogens have been replaced by methyl groups.
Names & identifiers
- Preferred name
- Octamethyltrisiloxane
- IUPAC
- dimethyl-bis(trimethylsilyloxy)silane
- English name
- Octamethyltrisiloxane
- Molecular formula
- C8H24O2Si3
- Molecular weight
- 236.53
Names & synonyms
OCTAMETHYLTRISILOXANE107-51-71,1,1,3,3,5,5,5-OctamethyltrisiloxaneTrisiloxane, octamethyl-dimethyl-bis(trimethylsilyloxy)silanePentamethyl(trimethylsilyloxy)disiloxaneDTXSID9040710Dimethylbis(trimethylsiloxy)silane9G1ZW13R0GPentamethyl(trimethylsiloxy)disiloxaneCHEBI:9147DTXCID7020710
Show more names
TRISILOXANEMETHYLPOLYSILOXANEO9816CO9816FRD 20KF 96A1csKF 96L1.0
RefChem:1093790203-497-4Dimethicone 350Simethicone Impurity 6Silicone oil PMX-200MFCD00008264S12475Trisiloxane, 1,1,1,3,3,5,5,5-octamethyl-
Database identifiers
- CAS
107-51-7- PubChem CID
- 24705
- DTXSID
DTXSID9040710- ChEMBL
CHEMBL2142985- ChEBI
Properties
Computed structural properties
- Topological polar surface area
- 18.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 149
Experimental & physicochemical properties
Chemical ClassesMetals -> Metalloid Compounds (Silicon)
Cosmetics
Cosmetics ingredient -> Bulking/Viscosity; Conditioning/Emollient; Moisturizing/Humectant; Other (Specify); Surfactant
Skin conditioning
SpringerMaterials PropertiesSchoenflies notation
Vapor Pressure3.34 [mmHg]
Physical Description
Liquid
Liquid; [Merck Index] Colorless odorless liquid; [Acros Organics MSDS]
Physicochemical properties
- Melting point
- -82 °C · -82 °C (lit.)
- Boiling point
- 153 °C · 153 °C (lit.)
- Density
- 0.82 g/mL · 0.82 g/mL at 25 °C (lit.)
- vapor density
- 1 · >1 (vs air)
- vapor pressure
- 5.3 hPa · 5.3hPa at 25℃
- refractive index
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 11.1% (49 of 443) of reports.
Warning
H226 (88.9%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P273, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 443 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Trisiloxane, octamethyl-
Hazard Traits - Bioaccumulation; Environmental Persistence
Trisiloxane, 1,1,1,3,3,5,5,5-octamethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Trisiloxane, 1,1,1,3,3,5,5,5-octamethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Octamethyltrisiloxane (EC: 203-497-4)
Substance: Octamethyltrisiloxane
Trisiloxane, octamethyl-: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Trisiloxane, octamethyl-: Human health tier II assessment
Hazards Summary
Causes histopathological liver changes at 1,000 mg/kg/day in 28-day oral study of rats; [EPA - TSCATS] No evidence of skin sensitization in human patch test studies; [ToxPlanet: Government of Canada - Chemicals Management Plan] May cause temporary redness and discomfort on eye contact; May cause CNS depression; [Acros Organics MSDS] See Tetrakis(trimethylsiloxy)silane. See Dimethoxydimethylsilane.
Chemistry & industry
Uses & manufacturing
Uses
Used as a base for extreme temperature silicone oils/fluids and as a foam suppressant in petroleum lubricating oils; [Merck Index] Used mainly to make polydimethylsiloxane (PDMS) polymers, oligomers, and mixtures; Also used to make basic chemicals, paints, coatings, adhesives, soaps, cleaning compounds, toiletries, plastics, semiconductors, and other electronic components, and in building construction, lubricants, diluents, solvents, and cosmetics; [Government of Canada - Chemicals Management Plan]
Semiconductor Manufacturing [Category: Industry]
U.S. Production2023: 1,000,000 - <5,000,000 lb
Consumer UsesDiluent
Industry UsesIntermediate
Household ProductsCosmetics product ingredient: Trisiloxane, octamethyl- (Octamethyltrisiloxane; Trisiloxane)
Use ClassificationCosmetics -> Skin conditioning
General Manufacturing Information
Other (requires additional information)
Trisiloxane, 1,1,1,3,3,5,5,5-octamethyl-: ACTIVE
Applications
UsesOctamethyltrisiloxane is a linear silicone oligomer. It is used as an excipient Dimethicones in pharmaceutical and cosmetic applications can provide long lasting lubricant, smooth feel and spreads easily. Studies demonstrate that it is able to maintain the conformational stability of certain adsorbed proteins such as bovine serum albumin (BSA). Used in the methylation of mercury(II) salts.
General DescriptionPoly(dimethylsiloxane) (PDMS), also known as dimethicone, is an organosilicon compound that is widely used as a siloxane based elastomer. It is a hydrophobic material with attractive physical and chemical properties such as elasticity, optical transparency, tunable surface chemistry, and low electrical conductivity.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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