Crl-8131

HCID 24751CAS 106392-12-5

Substructure search Find similar structures

Basic information

Standard SMILES: C1CO1.CC1CO1
InChIKey: RVGRUAULSDPKGF-UHFFFAOYSA-N
Molecular formula: C5H10O2
Average molar mass: 102.13 g/mol

Overview

Poloxamer is an epoxide.

Names & identifiers

Preferred name: Crl-8131
IUPAC: 2-methyloxirane;oxirane
English name: Poloxamer 188 CRS
Molecular formula: C18H36O5X2
Molecular weight: 102.13

Names & synonyms

CRL-8131RefChem:1082259106392-12-52-methyloxirane;oxiraneTERGITOL(TM)XH(NONIONIC)691397-13-4Pluronic LPluronic L 122F-108Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)ProxanolPoly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol)

Show more names

f127p123p84f108p65f88p105p104f77p85

Pluronic L44Oxirane, methyl-, polymer with oxiraneOTHER CA INDEX NAMES:Oxirane, polymer with methyloxiranePluronic L-81HydrowetProksanolRegulaidSlovanikMagcyl

Database identifiers

CAS: 106392-12-5、53637-25-5、9003-11-6
PubChem CID: 24751
ChEBI: CHEBI:32026

Properties

Computed structural properties

Topological polar surface area: 25.1 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 7
Formal charge: 0
Complexity: 36.7

Experimental & physicochemical properties

Cosmetics · 2 items

Cosmetic ingredients (Poloxamer 108) -> CIR (Cosmetic Ingredient Review)

Emulsifying; Surfactant

Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Physicochemical properties

Melting point: 57 · 57-61 °C
Density: 1.05 g/mL · 1.05 g/mL at 20 °C
refractive index: 20 · n20/D 1.456
storage temp.: -70 °C · -70°C
form: buffered aqueous solution
biological source: rabbit
Specific Activity: 434 · 434-657nmol/min·mg
SMILES: C(C)(CCOCCOCC(C)CCC*)COCCOC(C)CO* |$;;;;;;;;;;;;;;*;;;;;;;;;;*$|
Indirect Additives used in Food Contact Substances: POLY(ETHYLENE OXIDE-CO-PROPYLENE OXIDE), BLOCK
FDA 21 CFR: 176.17 · 176.170; 178.3400
EPA Substance Registry System: Propylene oxide ethylene oxide block polymer (106392-12-5)
UNSPSC Code: 12352203 · 12352203
NACRES: 41 · NA.41
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 332 · H332
Precautionary statements: 261 · P261-P271-P304+P340-P312
Hazard Codes: T
Risk Statements: 61 · 61
Safety Statements: 23 · 23-24/25-45-53
WGK Germany: 3 · 3
RTECS: 6164333 · TP6164333
Storage Class: 10 · 10 - Combustible liquids

Safety & regulation

Toxicology

Toxicity SummarySafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Safety data

wgk: 3
rtecs: TP6164333
risk_code: 61
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: T
safety_code: 23-24/25-45-53
Storage Class: 10 - Combustible liquids
Hazard statements: H332
Precautionary statements: P261-P271-P304+P340-P312

Chemistry & industry

Uses & manufacturing

UsesCIR ingredient: Poloxamer 108

Use ClassificationCosmetics -> Emulsifying; Surfactant

Applications · 2 items

UsesRecommended Starting Dilutions: For ICC/IF: Use at a concentration of 0.5 - 2 μg/mL. For IP: 1:100-1:500. For WB: Use at a concentration of 0.3 - 2 μg/mL. For ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher.

General DescriptionAnti-PI3-kinase p85-α Antibody detects endogenous levels of total PI3-kinase p85-α protein.