Crl-8131
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Basic information
- CAS
106392-12-5- Standard SMILES
C1CO1.CC1CO1- InChIKey
RVGRUAULSDPKGF-UHFFFAOYSA-N- Molecular formula
- C5H10O2
- Average molar mass
- 102.13 g/mol
- Monoisotopic mass
- 102.06807956
Overview
Poloxamer is an epoxide.
Names & identifiers
- Preferred name
- Crl-8131
- IUPAC
- 2-methyloxirane;oxirane
- English name
- Poloxamer 188 CRS
- Molecular formula
- C18H36O5X2
- Molecular weight
- 102.13
Names & synonyms
CRL-8131RefChem:1082259106392-12-5Pluronic F-682-methyloxirane;oxiraneTERGITOL(TM)XH(NONIONIC)691397-13-4Pluronic LPluronic L 122F-108Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)Proxanol
Show more names
f127p123p84f108p65f88p105p104f77p85
Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol)Pluronic L44Pluronic L-81HydrowetProksanolRegulaidSlovanikMagcyl
Database identifiers
- CAS
106392-12-5、53637-25-5、691397-13-4、9003-11-6- PubChem CID
- 24751
- ChEBI
CHEBI:32026
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 25.1 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 36.7
Experimental & physicochemical properties
Cosmetics
Cosmetic ingredients (Poloxamer 108) -> CIR (Cosmetic Ingredient Review)
Emulsifying; Surfactant
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physicochemical properties
- Melting point
- 57 · 57-61 °C
- Density
- 1.05 g/mL · 1.05 g/mL at 20 °C
- refractive index
- 20 · n20/D 1.456
- storage temp.
- -70 °C · -70°C
- form
- buffered aqueous solution
- biological source
- rabbit
- Specific Activity
- 434 · 434-657nmol/min·mg
- SMILES
- C(C)(CCOCCOCC(C)CCC*)COCCOC(C)CO* |$;;;;;;;;;;;;;;*;;;;;;;;;;*$|
- Indirect Additives used in Food Contact Substances
- POLY(ETHYLENE OXIDE-CO-PROPYLENE OXIDE), BLOCK
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Toxicology
Toxicity SummarySafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org
Safety data
- wgk
- 3
- rtecs
- TP6164333
- risk_code
- 61
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- T
- safety_code
- 23-24/25-45-53
- Storage Class
- 10 - Combustible liquids
- Hazard statements
- H332
- Precautionary statements
- P261-P271-P304+P340-P312
Chemistry & industry
Uses & manufacturing
UsesCIR ingredient: Poloxamer 108
Use ClassificationCosmetics -> Emulsifying; Surfactant
Applications
UsesRecommended Starting Dilutions: For ICC/IF: Use at a concentration of 0.5 - 2 μg/mL. For IP: 1:100-1:500. For WB: Use at a concentration of 0.3 - 2 μg/mL. For ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher.
General DescriptionAnti-PI3-kinase p85-α Antibody detects endogenous levels of total PI3-kinase p85-α protein.
Additional notes
DefinitionChEBI: Poloxamer is an epoxide.
Related reactions
15 records
Compound notes
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