Basic information
- CAS
4423-58-9- Standard SMILES
CC(=O)N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1- InChIKey
PIVQDUYOEIAFDM-GHMZBOCLSA-N- Molecular formula
- C11H14N2O5
- Average molar mass
- 254.24 g/mol
- Monoisotopic mass
- 254.09027155
Names & identifiers
- Preferred name
- N-[(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide
- IUPAC
- N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
- English name
- DL-THREO-2-ACETAMIDO-L-(4-NITROPHENYL)-L,3-PROPANEDIOL
- Molecular formula
- C11H14N2O5
- Molecular weight
- 254.24
Names & synonyms
N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamideN-[(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamideN-((1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)-2-propanyl)acetamideN-((1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamideRefChem:822795Corynecin I4423-58-94618-99-9N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamideNSC-63859DL-THREO-2-ACETAMIDO-L-(4-NITROPHENYL)-L,3-PROPANEDIOLEINECS 225-030-3
Show more names
Corynecin ⅠDechlorochloraMphenicol, DidechloraMphenicolAcetamide, N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-
K6QSE3RCF7MX6WP34G63orb1692103SCHEMBL12683648rel-N-[(1R,2R)-2-Hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamideDTXSID001382384NSC63859MFCD28899086
Database identifiers
Properties
Computed structural properties
- XLogP
- 0
- Topological polar surface area
- 115 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 296
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- form
- A solid
Chemistry & industry
Applications
DescriptionCorynecin I is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It is active against Gram-positive and Gram-negative bacteria with MIC values of 5.2-83 μg/ml for S. sonnei, P. vulgaris, K. pneumoniae, and S. aureus among others.
UsesCorynecin I is a member of a naturally-occurring complex of chloramphenicol-like acyl nitrophenylpropylamines isolated from Corynebacterium hydrocarboclastus in 1972. Corynecin I is active against Gram positive and Gram negative bacteria. Although less potent than chloramphenicol, corynecin I shows a similar species selectivity.
UsesCorynecin I is a chloramphenicol-like acyl nitrophenylpropylamine.
Upstream & downstream products
Upstream raw materials
Suppliers12 total
孟成科技（上海）有限公司400-820-6829 · [email protected]
上海维亦特生物科技有限公司15317051735 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
西安莱茵生物科技有限公司
Related reactions
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Compound notes
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