Basic information
- CAS
10075-24-8- Standard SMILES
CN(C)CCCN1c2ccccc2CCc2ccccc21.CN(C)CCCN1c2ccccc2CCc2ccccc21.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O- InChIKey
BPQZYOJIXDMZSX-UHFFFAOYSA-N- Molecular formula
- C61H64N4O6
- Average molar mass
- 949.2 g/mol
- Monoisotopic mass
- 948.48258577
Overview
Imipramine Pamoate is the pamoate salt of imipramine, a synthetic dibenzazepine derivative with anti-depressant activity. Imipramine pamoate, a tricyclic antidepressant (TCA) potentiates the activity of adrenergic synapses by blocking the re-uptake of norepinephrine and serotonin, thereby preventing their degradation and increasing their availability. This drug also has antimuscarinic and anti-histamine properties, which contribute to its side effects.
Names & identifiers
- Preferred name
- Imipramine Pamoate
- IUPAC
- 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;bis(3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine)
- English name
- Imipramine pamoate
- Molecular formula
- C42H40N2O6
- Molecular weight
- 668.79
Names & synonyms
Imipramine pamoate10075-24-8Tofranil-PMImipramine embonateMC34P30298DTXSID801434844,4'-Methylenebis(3-hydroxy-2-naphthoic) acid, compound with 10,11-dihydro-N,N-dimethyl-5H-dibenz(b,f)azepine-5-propylamine (1:2)4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine (1:2)RefChem:57885DTXCID6065975233-206-6Imipramine (pamoate)
Show more names
Imipramine Pamoate (1338481)10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)4,4'-methylenebis[3-hydroxy-2-naphthoic] acid, compound with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propylamine (1:2)2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine (1:2)4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid,3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Properties
Computed structural properties
- Topological polar surface area
- 128 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 12
- Heavy atoms
- 71
- Formal charge
- 0
- Complexity
- 859
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Yellow
- Major Application
- pharmaceuticalpharmaceutical (small molecule)
- InChIKey
- BPQZYOJIXDMZSX-UHFFFAOYSA-N
- SMILES
- N8(c9c(cccc9)CCc%10c8cccc%10)CCCN(C)C.N5(c6c(cccc6)CCc7c5cccc7)CCCN(C)C.Oc1c(c4c(cc1C(=O)O)cccc4)Cc2c3c(cc(c2O)C(=O)O)cccc3
- FDA UNII
- 34 P30298 · MC34P30298
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
- Symbol(GHS)
- 7 · GHS07,GHS09
- Signal word
- Warning
- Hazard statements
- 302 · H302-H400-H410
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P264, P270, P273, P301+P317, P308+P316, P321, P330, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- WGK 3
- hs_code
- 2933996100
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS09
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H400-H410
- Hazard Classifications
- Acute Tox. 4 Oral
- Precautionary statements
- P264-P270-P301+P312-P330-P501-P273-P391-P501-P273-P391-P501
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
IMIPRAMINE PAMOATE
Tricyclic Antidepressant [EPC]
MeSH Pharmacological Classification
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Applications
UsesImipramine Pamoate is a tricyclic antidepressant.
Suppliers14 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
ChemeGen 中国18818260767 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
西安美川生物科技有限公司029-89275612 +8618991951683 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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