HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylarsinic Acid
DIMETHYLARSINIC ACID · DIMETHYLARSONIC ACID · Ansar · Arsan · Dilic · Erase · Salvo · Phytar
Identifiers & Physical Properties
| CAS No. | 75-60-5 |
|---|---|
| Molecular formula | C2H7AsO2 |
| Average molar mass | 138 g/mol |
| Monoisotopic mass | 137.966199 g/mol |
| SMILES | C[As](C)(=O)O |
| InChIKey | OGGXGZAMXPVRFZ-UHFFFAOYSA-N |
| PubChem CID | 2513 |
| ChEMBL | CHEMBL1231644 |
| ChEBI | CHEBI:48765 |
| EC No. | 200-883-4 |
| DTXSID | DTXSID7020508 |
Chemical & Physical Properties
| Topological polar surface area | 37.3 |
|---|---|
| Hydrogen bond donors | 1 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 0 |
| Heavy atoms | 5 |
| Formal charge | 0 |
| Complexity | 62 |
| Chemical classes | Metals -> Arsenic Compounds, OrganicCarcinogens |
| Pesticides | Pesticide -> EPA IRIS |
| Odor | Odorless |
| Density | greater than 1.1 at 68 °F (est.) (USCG, 1999) |
| Color/Form | Crystals from alcohol and etherColorlessTRICLINIC CRYSTALSWhitewater solutions may be dyed blue |
| Solubility | Very soluble (NTP, 1992)Soluble in acetic acidSoluble in ethanolinsoluble in diethyl etherIn water, 2X10+6 mg/l @ 25 °C.Methanol (Slightly), Water (Slightly)Soluble in water (50 mg/ml), water (2000 at 25°C), alcohols, and acetic acid. Insoluble in ether. |
| Corrosivity | All formulations are mildly corrosive. |
| Boiling point | greater than 392 °F at 760 mmHg (NTP, 1992)>200 °C |
| Decomposition | When heated to decomposition it emits toxic fumes of /arsenics/.Decomposed by powerful oxidizing or reducing agents. |
| Melting point | 383 to 385 °F (NTP, 1992)195 °C195-198 °C |
| Vapor pressure | 0.0000001 [mmHg] |
| Physical Description | Cacodylic acid appears as a colorless, odorless crystalline solid. Melting point 195-196 °C. Toxic by ingestion and irritating to skin and eyes.Hygroscopic solid[Merck Index] Colorless odorless hygroscopic solid[CAMEO] White crystalline solid[MSDSonline] |
| Storage conditions | Store at RT. |
| pKa (acidity coefficient) | 1.57(at 25℃) |
| Physical state | Powder/Solid |
| Color | White |
| Sensitivity | Hygroscopic |
| Merck | 14,1604 |
| BRN | 1736965 |
| Stability | Aqueous solutions react violently with active metals. Incompatible with strong oxidizing agents, strong bases. |
| InChI | 1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5) |
| InChIKey | OGGXGZAMXPVRFZ-UHFFFAOYSA-N |
| SMILES | C[As](C)(O)=O |
| CAS DataBase Reference | 75-60-5(CAS DataBase Reference) |
| REACH Annex XVII Substances List | Dimethylarsinic acid (75-60-5) |
| EWG's Food Scores | 1 |
| FDA UNII | AJ2HL7EU8K |
| Proposition 65 List | Cacodylic Acid |
| IARC | 2B (Vol. 100C) 2012 |
| Pesticides Freedom of Information Act (FOIA) | Cacodylic acid |
| EPA Substance Registry System | Cacodylic acid (75-60-5) |
| UNSPSC Code | 12161700 |
| NACRES | NA.25 |
| GHS pictogram | GHS06,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H301-H331-H410 |
| GHS precautionary statements | P264-P270-P261-P271-P273-P301+P310-P330-P304+P340-P311-P391-P405-P403+P233-P501 |
| Hazard symbols | T,N |
| Risk statements (R) | 23/25-50/53 |
| Safety statements (S) | 20/21-28-45-60-61 |
| UN transport number | UN 1572 |
| Water hazard class (WGK) | 3 |
| RTECS number | CH7525000 |
| F | 3-10 |
| TSCA inventory status | TSCA listed |
| Hazard class | 6.1Acute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1Carc. 1B |
| Packing group | II |
| Customs code | 29310099 |
| Storage class | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Hazardous substances data | 75-60-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 1350 mg/kg (Bailey, White) |
Safety & Regulations
| GHS classification | DangerH301 (94.2%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 52 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatory information | Hazard Traits - CarcinogenicityCardiovascular ToxicityDermatotoxicityDevelopmental ToxicityNeurotoxicityOther Toxicological Hazard TraitsRespiratory ToxicityRestricted substance: Dimethylarsinic acidArsinic acid, dimethyl-: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Other safety information | IMAP assessments - Arsinic acid, dimethyl-: Environment tier I assessment |
| DOT label | Poison |
| Fire hazards | Behavior in Fire: May form toxic oxides of arsenic when heated. (USCG, 1999)· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. |
| Fire potential | Nonflammable |
| Health hazards | Chemical is essentially non-irritating in contact with skin or eyes. Ingestion causes arsenic poisoning, but symptoms are delayed. (USCG, 1999)· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin. |
| Hazards summary | There is sufficient evidence in experimental animals for the carcinogenicity of dimethylarsenic acid. . . . Arsenic in drinking-water is carcinogenic to humans (Group 1). [IARC] A forestry worker injecting trees with silvicide containing cacodylic acid developed anorexia, nausea, and abdominal painHe had elevated urine arsenic, and symptoms subsided after termination of exposure |
Applications & Uses
Description
Cacodylic acid is a colorless, odorless,crystalline solid arsenic compound. Molecular weight =138.02; Boiling point=200℃; Freezing/Melting point 5192℃. Hazard Identification (based on NFPA-704 MRating System): Health 4, Flammability 0, Reactivity 0.[NJ]Highly soluble in water.
Uses
antieczema, dermatologic, herbicide
Uses
A useful arsenic acid for proteomics research. It a good substitute for phosphate in applications to avoid phosphates. Cacodylic Acid is useful for some DNA applications and is also popular in microscopy.
Uses
Cacodylic acid is used for dermatologic treatment in cronic eczema, anemia and as a tonic.
General Description
A colorless, odorless crystalline solid. Melting point 195-196°C. Toxic by ingestion and irritating to skin and eyes.