Trolamine Salicylate
TROLAMINE SALICYLATE · TEA-SALICYLATE · Triethanolamine salicylate · Triethanolaminium salicylate · Triethanolamine salicylate,99% · Salicylic acid·triethanolamine · Salicylicacidtriethanolaminesalt · Trolamine salicylate in methanol
Identifiers & Physical Properties
| CAS No. | 2174-16-5 |
|---|---|
| Molecular formula | C13H21NO6 |
| Average molar mass | 287.31 g/mol |
| Monoisotopic mass | 287.13688739 g/mol |
| SMILES | O=C(O)c1ccccc1O.OCCN(CCO)CCO |
| InChIKey | UEVAMYPIMMOEFW-UHFFFAOYSA-N |
| PubChem CID | 25213 |
| ChEMBL | CHEMBL2107288 |
| EC No. | 218-531-3 |
| DTXSID | DTXSID4047969 |
Chemical & Physical Properties
| Topological polar surface area | 121 |
|---|---|
| Hydrogen bond donors | 5 |
| Hydrogen bond acceptors | 7 |
| Rotatable bonds | 7 |
| Heavy atoms | 20 |
| Formal charge | 0 |
| Complexity | 189 |
| Solubility | Soluble |
| Boiling point | Decomposes |
| Melting point | 50 |
| Density | 1.209 g/mL at 25 °C |
| Refractive index | n20/D 1.509 |
| Flash point | 113 °C |
| Odor | dull pleasent sweet |
| BRN | 7451205 |
| Cosmetics Ingredients Functions | PRESERVATIVEUV FILTERLIGHT STABILIZER |
| InChI | InChI=1S/C7H6O3.C6H15NO3/c8-6-4-2-1-3-5(6)7(9)108-4-1-7(2-5-9)3-6-10/h1-4,8H,(H,9,10)8-10H,1-6H2 |
| InChIKey | UEVAMYPIMMOEFW-UHFFFAOYSA-N |
| SMILES | C(C1C=CC=CC=1O)(=O)O.N(CCO)(CCO)CCO |
| LogP (partition coefficient) | -1.108 (est) |
| CAS DataBase Reference | 2174-16-5(CAS DataBase Reference) |
| FDA 21 CFR | 310.545 |
| FDA UNII | H8O4040BHD |
| EPA Substance Registry System | Benzoic acid, 2-hydroxy-, compd. with 2,2',2''-nitrilotris[ethanol] (1:1) (2174-16-5) |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard symbols | Xn |
| Risk statements (R) | 20/21/22-36/37/38-22 |
| Safety statements (S) | 24/25-36-26 |
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| Customs code | 29225000 |
Safety & Regulations
| GHS classification | WarningH302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatory information | Chemical: Benzoic acid, 2-hydroxy-, compound with 2,2',2''-nitrilotris[ethanol] (1:1) |
| Other safety information | IMAP assessments - Benzoic acid, 2-hydroxy-, compound with 2,2',2''-nitrilotris[ethanol] (1:1): Human health tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (97.6%)Skin Irrit. 2 (100%)Eye Irrit. 2 (100%)STOT SE 3 (100%) |
| Toxicity summary | The Panel concluded that the following ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment, when formulated to be non-irritating and non-sensitizing, which may be based on a quantitative risk assessment (QRA)...TEA-Salicylate...Safe for use in cosmetics, with qualifications |
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| Customs code | 29225000 |
| Risk statements (R) | 20/21/22-36/37/38-22 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xn |
| Safety statements (S) | 24/25-36-26 |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
Applications & Uses
Uses
TEA-salicylate is a chemical uVB absorber. This is one of the 21 FDAapproved sunscreen chemicals with an approved usage level of 5 to 12 percent. TeA-salicylate is a water-soluble chemical with limited uV absorption capability. Formulators may also use it as a preservative.
Uses
TriethanolaMine salicylate can be used as intermediate in the manufacture of surface active agents, textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, cutting oils. In making emulsions with mineral and vegetable oils, paraffin and waxes. Solvent for casein, shellac, dyes; manufacture of synthetic resins; increasing the penetration of organic liquids into wood and paper. In the production of lubricants for the textile industry. Pharmaceutic aid (alkalizer).