Basic information
- CAS
10450-60-9- Standard SMILES
[O-][I+](O)(O)(O)(O)O- InChIKey
DSFFTJWVPXAHPD-UHFFFAOYSA-N- Molecular formula
- H5IO6
- Average molar mass
- 227.94 g/mol
- Monoisotopic mass
- 227.91308588
Overview
Orthoperiodic acid is an iodine oxoacid. It is a conjugate acid of an orthoperiodate(1-).
Names & identifiers
- Preferred name
- Orthoperiodic acid
- IUPAC
- pentahydroxy(oxo)-λ7-iodane
- English name
- Periodic acid
- Molecular formula
- H5IO6
- Molecular weight
- 227.94057
Names & synonyms
10450-60-9Orthoperiodic acidPeriodic acid (H5IO6)H5IO6hexaoxoiodic(5-) acidpentahydroxidooxidoiodineAK1D44L87Gpentahydrogen hexaoxoiodate(5-)pentahydroxy-lambda(7)-iodanone[IO(OH)5]CHEBI:29150(IO(OH)5)
Show more names
PeriodateperiodicPERIODIC ACIPeriodic acid, ACS, 99.01-101.0%Periodic acidPeriodicAcidePeriodicAcidGrPeriodicAcid50%
RefChem:168606233-937-0pentahydroxy(oxo)-lambda7-iodaneMFCD00011344PERIODIC ACID, CRYSTParaperiodic acidIodic Acid; Orthoperiodic Acid; Paraperiodic Acid;UNII-AK1D44L87G
Database identifiers
- CAS
10450-60-9- PubChem CID
- 25289
- DTXSID
DTXSID10883144- ChEBI
CHEBI:29150- UNII
- AK1D44L87G
- EC Number
- 233-937-0
- Nikkaji
- J96.462J
Properties
Computed structural properties
- XLogP
- -2.1
- Topological polar surface area
- 118 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 0
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 122
Experimental & physicochemical properties
Melting Point130 °C
Physical DescriptionSolid
Physicochemical properties
- Melting point
- 122 °C · 122 °C (lit.)
- Boiling point
- 140 °C · 140°C
- Density
- 417 · d417 1.3875; d 1.42
- bulk density
- 1400 kg/m3 · 1400kg/m3
- vapor pressure
- 7.6 Pa · 7.6Pa at 25℃
- RTECS
- 1269700 · NN1269700
- Flash point
- 140 °C · 140°C
- storage temp.
- 15 °C · Store at +15°C to +25°C.
- solubility
- soluble in Methanol, Water
- form
- Solid
- color
- White to slightly yellow
- PH
- 1.2 · 1.2 (100g/l, H2O, 20℃)
- Water Solubility
- Soluble in water and alcohols.
- Sensitive
- Moisture & Light Sensitive
- Merck
- 14 · 14,7171
- Stability
- Stable, but strong oxidizer. Contact with combustible material may cause fire. Hygroscopic. Incompatible with organic materials, strong reducing agents.
- InChI
- 1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
- InChIKey
- TWLXDPFBEPBAQB-UHFFFAOYSA-N
- SMILES
- OI(O)(O)(O)(O)=O
- Substances Added to Food (formerly EAFUS)
- PERIODIC ACID
- CAS DataBase Reference
- 10450 · 10450-60-9(CAS DataBase Reference)
- FDA UNII
- 1 D44L87G · AK1D44L87G
- EPA Substance Registry System
- Periodic acid (H5IO6) (10450-60-9)
- UNSPSC Code
- 41105319 · 41105319
- NACRES
- 22 · NB.22
- Symbol(GHS)
- 3 · GHS03,GHS05,GHS09
- Signal word
- Danger
- Hazard statements
- 271 · H271-H314-H318-H400-H410
- Precautionary statements
- 210 · P210-P220-P280-P283-P260-P264-P273-P306+P360-P371+P380+P375-P370+P378-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P391-P420-P405-P501
- target organs
- Thyroid
- Hazard Codes
- C,O
- Risk Statements
- 8 · 8-34
- Safety Statements
- 26 · 26-27-36/37/39-45-17-36
- RIDADR
- 3264 · UN 3264 8/PG 2
- WGK Germany
- 3 · 3
- F
- 3 · 3-8
- TSCA
- TSCA listed
- HS Code
- 2811 · 2811 19 80
- HazardClass
- 5.1 · 5.1
- PackingGroup
- II
- Storage Class
- 5.1 A · 5.1A - Strongly oxidizing hazardous materials
- Hazard Classifications
- 1 Aquatic · Aquatic Acute 1Aquatic Chronic 1Eye Dam. 1Ox. Sol. 1Skin Corr. 1BSTOT RE 1 Oral
- REACH Registrations
- Active
- Limited Quantities
- 1 kg · 1.0 kg (2.2 lbs) (solid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
Safety & regulation
GHS classification
GHS Classification
Danger
H271 (69.8%): May cause fire or explosion; strong Oxidizer [Danger Oxidizing liquids; Oxidizing solids]
P210, P220, P260, P264, P264+P265, P270, P273, P280, P283, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P306+P360, P316, P317, P319, P321, P363, P370+P378, P371+P380+P375, P391, P405, P420, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 325 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
H302: Harmful if swallowed [Warning Acute toxicity, oral]
Hazard information
Regulatory Information
Chemical: Periodic acid (H5IO6)
Status: Active Update: 10-02-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/27603
Orthoperiodic acid: HSNO Approval: HSR001335 Approved with controls
Other Safety InformationIMAP assessments - Periodic acid and its salts: Human health tier II assessment
Hazard Classes and Categories
Ox. Sol. 1 (69.8%)
Acute toxicity (ingestion) - category 4
Safety data
- F
- 3-8
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- UN 3264 8/PG 2
- hs_code
- 2811 19 80
- risk_code
- 8-34
- Signal word
- Danger
- Symbol(GHS)
- GHS03,GHS05,GHS09
- hazard_code
- C,O
- safety_code
- 26-27-36/37/39-45-17-36
- hazard_class
- 5.1
- Storage Class
- 5.1A - Strongly oxidizing hazardous materials
- packing_group
- II
- target organs
- Thyroid
- Hazard statements
- H271-H314-H318-H400-H410
- Limited Quantities
- 1.0 kg (2.2 lbs) (solid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
- REACH Registrations
- Active
- Hazard Classifications
- Aquatic Acute 1Aquatic Chronic 1Eye Dam. 1Ox. Sol. 1Skin Corr. 1BSTOT RE 1 Oral
- Precautionary statements
- P210-P220-P280-P283-P260-P264-P273-P306+P360-P371+P380+P375-P370+P378-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P391-P420-P405-P501
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationPeriodic acid (H5IO6): ACTIVE
Applications
UsesPeriodic acid is used as a component for glycoprotein stains. It serves as a pharmaceutical and synthetic intermediate and is used in silk screen printing. It acts as an oxidizing agent especially the cleavage of 1,2 diols to prepare dialdehydes. It has selective oxidation powers which makes it an ideal reagent for the reclamation of silk screens in the printing industry. It finds application in life sciences for the analysis of intracellular polysaccharides like glycogen, starch and cellulose. Furthermore, it is used in the oxidation reactions converting sulfides into sulfones, catalyzed by chromium(VI) oxide and oxidation reactions converting alcohols to aldehydes and ketones.
UsesPERIODIC ACID is used as an oxidiser and in the determination of manganese.
UsesIn organic synthesis.
General DescriptionPeriodic acid (H5IO6) is an oxoacid of iodine. It is commonly used as an oxidizing agent in organic synthesis for the preparation of useful chemical intermediates. Periodic acid is also used in oxidative cleavage reactions.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
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Additional notes
DefinitionChEBI: Orthoperiodic acid is an iodine oxoacid. It is a conjugate acid of an orthoperiodate(1-).
Related reactions
10 records
Compound notes
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