2-Aminoadamantane hydrochloride
2-AdamantylamineHCl · IFLAB-BB F1928-0024 · 2-AMINOADAMANTANEHCL · 2-ADAMANTANAMINE HCL · 2-admantylamine hydrochloride · 2-Adamantanamin hydrochloride · 2-ADAMANTANAMINE HYROCHLORIDE · 2-ADAMANTANAMINE HYDROCHLORIDE
Identifiers & Physical Properties
| CAS No. | 10523-68-9 |
|---|---|
| Molecular formula | C10H18ClN |
| Average molar mass | 187.71 g/mol |
| Monoisotopic mass | 187.11277726 g/mol |
| SMILES | Cl.NC1C2CC3CC(C2)CC1C3 |
| InChIKey | WLDWDRZITJEWRJ-UHFFFAOYSA-N |
| PubChem CID | 25331 |
| ChEMBL | CHEMBL447911 |
| EC No. | 234-074-2 |
| DTXSID | DTXSID60147021 |
Chemical & Physical Properties
| Topological polar surface area | 26 |
|---|---|
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 1 |
| Rotatable bonds | 0 |
| Heavy atoms | 12 |
| Formal charge | 0 |
| Complexity | 148 |
| Melting point | >300 °C(lit.) |
| Storage conditions | Inert atmosphere,Room Temperature |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly)soluble |
| Physical state | Crystalline Powder |
| Color | White |
| BRN | 4297901 |
| InChI | InChI=1/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6/h6-10H,1-5,11H21H/t6-,7+,8-,9+,10 |
| InChIKey | WLDWDRZITJEWRJ-ZDAMNCSYNA-N |
| SMILES | C1(N)[C@@]2([H])C[C@]3([H])C[C@]([H])(C2)C[C@@]1([H])C3.Cl |&1:2,5,8,12,r| |
| CAS DataBase Reference | 10523-68-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Target organs | Respiratory system |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard symbols | Xi,Xn |
| Risk statements (R) | 36/37/38-22 |
| Safety statements (S) | 26-36-36/37/39-22 |
| Water hazard class (WGK) | 3 |
| RTECS number | AU4375100 |
| F | 10 |
| Hazard class | IRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Customs code | 29213000 |
| Storage class | 11 - Combustible Solids |
Safety & Regulations
| GHS classification | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 48 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| F | 10 |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Water hazard class (WGK) | 3 |
| RTECS number | AU4375100 |
| Customs code | 29213000 |
| Risk statements (R) | 36/37/38-22 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi,Xn |
| Safety statements (S) | 26-36-36/37/39-22 |
| Hazard class | IRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Storage class | 11 - Combustible Solids |
| Target organs | Respiratory system |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Applications & Uses
Uses
2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders.
Uses
2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
General Description
The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.