Basic information
- CAS
13435-12-6- Standard SMILES
CC(=O)N[Si](C)(C)C- InChIKey
LWFWUJCJKPUZLV-UHFFFAOYSA-N- Molecular formula
- C5H13NOSi
- Average molar mass
- 131.25 g/mol
- Monoisotopic mass
- 131.07664057
Names & identifiers
- Preferred name
- Acetamide, N-(trimethylsilyl)-
- IUPAC
- N-trimethylsilylacetamide
- English name
- N-(Trimethylsilyl)acetamide
- Molecular formula
- C5H13NOSi
- Molecular weight
- 131.25
Names & synonyms
N-(Trimethylsilyl)acetamide13435-12-6N-TrimethylsilylacetamideACETAMIDE, N-(TRIMETHYLSILYL)-Trimethylsilylacetamide(Acetylamino)trimethylsilaneEINECS 236-565-7NSC 139859BRN 0741928DTXSID80654544-04-00-04011 (Beilstein Handbook Reference)RefChem:551795
Show more names
trimethylsilylTMSACMH3DK063CMD1YLVNC9C15orf13HEL-S-265HTM-alpha
DTXCID2034205236-565-7C5H13NOSiAcetamide, TMS derivativeMFCD00008671n-trimethylsilyl-acetamideTMS acetamideS18875
Database identifiers
- CAS
13435-12-6- PubChem CID
- 25989
- DTXSID
DTXSID8065454- EC Number
- 236-565-7
- Nikkaji
- J55.333F
Properties
Computed structural properties
- Topological polar surface area
- 29.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 1
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 95
Physicochemical properties
- Melting point
- 46 · 46-49 °C(lit.)
- Boiling point
- 84 °C18 · 84 °C18 mm Hg(lit.)
- Density
- 0.859 · 0.859±0.06 g/cm3(Predicted)
- Flash point
- 135 °F · 135 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, DMSO, Methanol
- pka
- 18.23 · 18.23±0.46(Predicted)
- form
- Crystalline Mass
- color
- White to yellow
- Water Solubility
- reacts
- Sensitive
- Moisture Sensitive
- Hydrolytic Sensitivity
- 7 · 7: reacts slowly with moisture/water
- BRN
- 741928 · 741928
- Stability
- Moisture Sensitive
- InChI
- 1S/C5H13NOSi/c1-5(7)6-8(2,3)4/h1-4H3,(H,6,7)
- InChIKey
- LWFWUJCJKPUZLV-UHFFFAOYSA-N
- SMILES
- CC(=O)N[Si](C)(C)C
- CAS DataBase Reference
- 13435 · 13435-12-6(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- EPA Substance Registry System
- Acetamide, N-(trimethylsilyl)- (13435-12-6)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319
- Precautionary statements
- 302 · P302+P352-P305+P351+P338
- PPE
- 3 · Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
- Hazard Codes
- Xi-F,Xi,F
- Risk Statements
- 36 · 36/37/38-11
- Safety Statements
- 37 · 37/39-26
- RIDADR
- 1325 · 1325
- WGK Germany
- 3 · 3
- RTECS
- 250000 · AD0250000
- F
- 10 · 10-21
- TSCA
- TSCA listed
- HazardClass
- 4.1 · 4.1
- PackingGroup
- III
- HS Code
- 29319090 · 29319090
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 2 Skin · Eye Irrit. 2Skin Irrit. 2
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 84.4% (38 of 45) of all reports.
Warning
H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 38 of 45 reports by companies.；There are 4 notifications provided by 7 of 45 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: Acetamide, N-(trimethylsilyl)-
Acetamide, N-(trimethylsilyl)-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (11.1%)；Eye Irrit. 2 (11.1%)
Regulatory information
Regulatory Information
Chemical: Acetamide, N-(trimethylsilyl)-
Acetamide, N-(trimethylsilyl)-: Does not have an individual approval but may be used under an appropriate group standard
Safety data
- F
- 10-21
- PPE
- Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- AD0250000
- ridadr
- 1325
- hs_code
- 29319090
- risk_code
- 36/37/38-11
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi-F,Xi,F
- safety_code
- 37/39-26
- hazard_class
- 4.1
- Storage Class
- 11 - Combustible Solids
- packing_group
- III
- Hazard statements
- H315-H319
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2
- Precautionary statements
- P302+P352-P305+P351+P338
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationAcetamide, N-(trimethylsilyl)-: ACTIVE
Applications
UsesN-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).
General DescriptionThe efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.
Upstream & downstream products
Downstream products
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
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Related reactions
80 records
Compound notes
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