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Copper Arsenate

HCID 26065
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Basic information

CAS
10103-61-4
Standard SMILES
O=[As]([O-])([O-])[O-].O=[As]([O-])([O-])[O-].[Cu+2].[Cu+2].[Cu+2]
InChIKey
RKYSWCFUYJGIQA-UHFFFAOYSA-H
Molecular formula
As2Cu3O8
Average molar mass
468.48 g/mol
Monoisotopic mass
466.5913

Overview

Copper arsenate is a chemical compound of copper and arsenic. It is derived from arsenic acid and used mainly as a pesticide. Copper is a chemical element with the symbol Cu and atomic number 29. Copper is an essential elements in plants and animals as it is required for the normal functioning of more than 30 enzymes. It occurs naturally throughout the environment in rocks, soil, water, and air. Arsenic is a chemical element that has the symbol As and atomic number 33. It is a poisonous metalloid that has many allotropic forms: yellow (molecular non-metallic) and several black and grey forms (metalloids) are a few that are seen. Three metalloidal forms of arsenic with different crystal structures are found free in nature (the minerals arsenopyrite and the much rarer arsenolamprite and pararsenolamprite), but it is more commonly found as a compound with other elements. (T3, L277, L278, L380)

Names & identifiers

Preferred name
Copper Arsenate
IUPAC
tricopper diarsorate
English name
arsenic acid, copper salt
Molecular formula
AsCuH3O4
Molecular weight
205.49

Names & synonyms

Copper arsenateCupric arsenateUNII-EV78GZO3YSEV78GZO3YSDTXSID30894196RefChem:57896Olivenite 6 Special OrderDTXCID40132424329871-13-4tricopper;diarsorateArsenic acid, copper salt7778-41-8
Show more names
tricoppercopper arsenate, basic
10103-61-4Arsenic acid (H3AsO4), copper(2+) salt (2:3)Caswell No. 232EINECS 233-286-2Kupfer(II)-arsenatArsenic acid (H3AsO4), copper saltEPA Pesticide Chemical Code 022801Arsenic acid (H3AsO4), copper salt (1:?)

Database identifiers

CAS
10103-61-4、7778-41-8
PubChem CID
26065
DTXSID
DTXSID30894196
UNII
EV78GZO3YS
EC Number
233-286-2

Properties

Computed structural properties

Topological polar surface area
173 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
8
Rotatable bonds
0
Heavy atoms
13
Formal charge
0
Complexity
36.8

Experimental & physicochemical properties

Chemical Classes · 2 items

Metals -> Arsenic Compounds, Inorganic

Metals -> Arsenic Compounds, Inorganic

Physical Description · 2 items

Blue or bluish-green solid; [ICSC]

Light blue, blue, or bluish green solid; [Hawley] Blue-green to blue insoluble powder; [Ullmann]

Physicochemical properties

solubility
2 O, · insoluble in H2O, ethanol; soluble in dilute acid solutions
form
blue-green crystals
color
blue-green crystals, crystalline
Water Solubility
2 O, · insoluble H2O, alcohol; soluble dilute acids, NH4OH [HAW93]
REACH Annex XVII Substances List
Arsenic acid, copper salt (10103-61-4)
FDA UNII
78 GZO3YS · EV78GZO3YS
EPA Substance Registry System
Copper arsenate (10103-61-4)
RIDADR
3288 · 3288
TSCA
TSCA listed

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 6 items

Danger

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P203, P260, P264, P264+P265, P270, P280, P305+P351+P338, P308+P316, P318, P319, P321, P337+P317, P405, and P501 (click each P-code to see the statement)

Danger

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

P203, P260, P264, P264+P265, P270, P280, P305+P351+P338, P308+P316, P318, P319, P321, P337+P317, P405, and P501 (click each P-code to see the statement)

Hazard information

Regulatory InformationRestricted substance: Arsenic acid, copper salt
Hazards Summary · 2 items

An eye and respiratory tract irritant; Can be absorbed through skin; Also toxic by ingestion or inhalation of aerosol; Arsenic compounds are carcinogenic to humans; [ICSC] See Arsenic and the linked occupational diseases.

Copper Arsenate is probably the basic cupric arsenate. It has variable composition with approximately 33% copper and 29% arsenic. [Hawley] See Arsenic and the linked occupational diseases.

Hazard Classes and Categories · 2 items

Serious eye damage/eye irritation - Category 2

Serious eye damage/eye irritation - Category 2B

Safety & protection

Exposure Control and Personal Protection · 4 items

Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek;

0.1 [mg/m3], inhalable fraction (Cu inorg. compds.)[German Research Foundation (DFG)]

Chemistry & industry

Pharmacology

Metabolism/Metabolites · 1 item

Copper is mainly absorbed through the gastrointestinal tract, but it can also be inhalated and absorbed dermally. It passes through the basolateral membrane, possibly via regulatory copper transporters, and is transported to the liver and kidney bound to serum albumin. The liver is the critical organ for copper homoeostasis. In the liver and other tissues, copper is stored bound to metallothionein, amino acids, and in association with copper-dependent enzymes, then partitioned for excretion through the bile or incorporation into intra- and extracellular proteins. The transport of copper to the peripheral tissues is accomplished through the plasma attached to serum albumin, ceruloplasmin or low-molecular-weight complexes. Copper may induce the production of metallothionein and ceruloplasmin. The membrane-bound copper transporting adenosine triphosphatase (Cu-ATPase) transports copper ions into and out of cells. Physiologically normal levels of copper in the body are held constant by alterations in the rate and amount of copper absorption, compartmental distribution, and excretion. Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20, L277, L279)

Uses & manufacturing

Uses · 3 items

Used as an insecticide and fungicide; [Hawley] Used as an insecticide, fungicide, rodenticide, wood preservative, and antifouling pigment; [Ullmann]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

Copper arsenate is used as an insecticide, herbicide, fungicide, and rodenticide. (L380)

General Manufacturing Information · 2 items

Arsenic acid (H3AsO4), copper(2+) salt (2:3): INACTIVE

Related reactions

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Compound notes

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HazardClass
6.1 · 6.1(a)
PackingGroup
II

Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek;

0.01 [mg/m3], respirable fraction (Cu, inorganic cmpnds)[German Research Foundation (DFG)]

Minimum Risk LevelAcute Oral: 0.01 mg/kg/day (Copper) (L134) Intermediate Oral: 0.01 mg/kg/day (Copper) (L134) Acute Oral: 0.005 mg/kg/day (Arsenic) (L134) Chronic Oral: 0.0003 mg/kg/day (Arsenic) (L134) Chronic Inhalation: 0.01 mg/m3 (Arsenic) (L134)
Threshold Limit Values (TLV) · 2 items

0.01 [mg/m3], as As

0.01 [mg/m3], as As

Permissible Exposure Limit (PEL) · 2 items

0.01 [mg/m3], as As

0.01 [mg/m3], as As

Immediately Dangerous to Life or Health (IDLH) · 2 items

5.0 [mg/m3], as As

5.0 [mg/m3], as As

Toxicology

Treatment · 1 item

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Health Effects · 1 item

People must absorb small amounts of copper every day because copper is essential for good health, however, high levels of copper can be harmful. Very-high doses of copper can cause damage to your liver and kidneys, and can even cause death. Copper may induce allergic responses in sensitive individuals. Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20, L278, L279)

Adverse Effects · 2 items

Neurotoxin - Sensorimotor

Neurotoxin - Sensorimotor

Exposure RoutesOral (L2) ; inhalation (L2); dermal (L2)
Toxicity Summary · 1 item

Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17, L277, T49, A174, L280)

Signs and Symptoms · 1 item

Breathing high levels of copper can cause irritation of the nose and throat. Ingesting high levels of copper can cause nausea, vomiting, diarrhea, headache, dizziness, and respiratory difficulty. Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).

Carcinogen Classification1, carcinogenic to humans. (L135)
Toxicity DataLD50: 2147 mg/kg (Oral, Rat) (L927)

Safety data

tsca
TSCA listed
ridadr
3288
hazard_class
6.1(a)
packing_group
II

Arsenic acid (H3AsO4), copper salt (1:?): INACTIVE