S-propyl chlorothioformate

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Use water, dry chemicals, foam or carbon dioxide. If drums are not leaking, keep cooled with a water spray. High pressure water hose may spread product from broken containers increasing contamination hazards. Use of contaminated buildings, areas and equipment must be prevented until they are properly decontaminated.

Soak up pooled liquid with a suitable neutralizing absorbent, such as dry calcium hydroxide. Exercise caution during the neutralization as considerable heat may be generated. Place the absorbed material into a suitable chemical waste container. Apply diethanolamine (DEA) to the spill area and allow to stand for 5 min. Using wet towels, wipe up the DEA. Flush the spill area to remove residual DEA.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

Firefighters should wear full-face, self-contained breathing apparatus and impervious clothing such as gloves, hoods, suits and rubber boots.

Atmospheric: photolysis and hydrolysis in water droplets should rapidly destroy the cmpd in the atmosphere.

S-(n-propyl) chlorothioformate is likely to have minimal environmental release. The manufacture of the cmpd should take place in a closed system. Use of this cmpd as an intermediate in preparation of pesticides is likely to also occur in a closed system.

Atmospheric: ... based on its estimated volatility the cmpd could move into the atmosphere.

Propyl mercaptan, a hydrolysis product of s-(n-propyl)chlorothioformate caused severe irritation to the eye of a rabbit at 83 mg. /propyl mercaptan/

S-(n-propyl) chlorothioformate may act as ... a vesicant and, after inhalation, may produce respiratory tract effects due to release of HCl by hydrolysis and acylation of tissue nucleophiles.

A single oral dose of 566 mg/kg did not produce signs of toxicity in male or female rats. Signs of toxicity at larger, /not specified/, doses included decreased physical activity, lacrimation, piloerection and weakened righting and placement reflexes.

A single one-hr inhalation exposure of 1.3 mg/l (nominal concn) produced ataxia, gasping, lacrimation and 70% mortality in rats. Necropsy revealed pulmonary edema, and congested liver and/or lungs.

Hydrolysis rate constant of s-(n-propyl) chlorothioformate is 29.6 x 10-4; half-life (min) 3.9 in water at 4.6 °C.

S-(n-propyl) chlorothioformate hydrolyzes to produce n-propyl mercaptan.

Ingestion: do not induce vomiting. Immediately give large quantities of water. If vomiting does occur, give fluids again. Never give anything by mouth to an unconscious person.

Skin contact; Immediately remove contaminated clothing, wiping away excess material from the skin. Under a safety shower, flush all affected areas with large amounts of water for at least 15 min. Do not attempt to neutralize with chemical agents.

Eye contact: Immediately flush the eyes with large quantities of water for a minimum of 15 min. Hold the eyelids apart during the flushing to ensure rinsing of the entire surface of the eye and lids with water. Do not attempt to neutralize with chemical agents. Obtain medical attention as soon as possible. Oils or ointments should not be used. Continue the flushing for an additional 15 minutes if the physician is not immediately available.

Inhalation: Remove from contaminated atmosphere. If breathing has ceased, clear the victim's airway and start mouth-to-mouth artificial respiration, which may be supplemented by the use of a bag-mask respirator or a manually-triggered, oxygen supply capable of delivering one l/sec or more. If the victim is breathing, oxygen may be delivered from a demand-type or continuous-flow inhalator, preferably with a physician's advice

LD50 rat po 1129 mg/kg; toxic effects: eye, skin, and behavioral symptoms

LD50 rabbit dermal 4500 mg/kg