Basic information
- CAS
14919-77-8- Standard SMILES
Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O- InChIKey
ULFCBIUXQQYDEI-UHFFFAOYSA-N- Molecular formula
- C10H16ClN3O5
- Average molar mass
- 293.7 g/mol
- Monoisotopic mass
- 293.0778483
Overview
Benserazide hydrochloride is a hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions when given alone. It has a role as an antiparkinson drug, a dopaminergic agent and an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor. It contains a benserazide(1+).
Names & identifiers
- Preferred name
- Benserazide Hydrochloride
- IUPAC
- 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide;hydrochloride
- English name
- Benserazide hydrochloride
- Molecular formula
- C10H16ClN3O5
- Molecular weight
- 293.7
Names & synonyms
BENSERAZIDE HYDROCHLORIDE14919-77-8Benserazide HCl2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochlorideRo 4-4602/0012'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazide monohydrochlorideDTXSID0045412DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazine hydrochlorideB66E5RK36QCHEBI:31262DTXCID8025412RefChem:1077794
Show more names
RO 4-4602BENPARIZDE31796-68-6NCGC00093698-03SPECTRUM1500137Benserazide hydrochloBenserazid hydrochloride
(2RS)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanoylhydrazide monohydrochloride238-991-9Benzerazide hydrochlorideBenserazide HCIDL-SERINE 2MFCD00078571Benserazide hydrochloride [JAN]DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
Database identifiers
- CAS
14919-77-8
Properties
Computed structural properties
- Topological polar surface area
- 148 Ų
- Hydrogen bond donors
- 8
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 5
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 278
Experimental & physicochemical properties
Solubility35.4 [ug/mL] (The mean of the results at pH 7.4)
Physicochemical properties
- Melting point
- 146 °C · 146°C
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: 10 mg/mL
- form
- solid
- color
- White to Off-White
- PH
- pH(10g/L, 25℃) : 4.0～5.0
- biological source
- synthetic
- Water Solubility
- Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.
- Sensitive
- Light Sensitive
- λmax
- 272 nm · 272nm(HCl aq.)(lit.)
- Merck
- 14 · 14,1050
- InChI
- InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
- InChIKey
- ULFCBIUXQQYDEI-UHFFFAOYSA-N
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (43%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 93 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (43%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 2
- rtecs
- VT9632300
- hs_code
- 29280000
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
- Hazard statements
- H315-H319-H335
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P302+P352-P305+P351+P338
Chemistry & industry
Applications
DescriptionBenserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.
UsesUsed as antiparkinsonian. A peripheral decarboxylase inhibitor
UsesAntiparkinsonian;DOPA decarboxylase inhibitor
UsesInhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.
General DescriptionBenserazide is a peripheral decarboxylase inhibitor.
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
河北展药生物科技有限公司15369953316 +8615369953316 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
Related reactions
0 records
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Compound notes
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