Basic information
- CAS
62-37-3- Standard SMILES
COC(CNC(N)=O)[CH2][Hg][Cl]- InChIKey
BJFGVYCULWBXKF-UHFFFAOYSA-M- Molecular formula
- C5H11ClHgN2O2
- Average molar mass
- 367.2 g/mol
- Monoisotopic mass
- 368.021549
Overview
Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.
Names & identifiers
- Preferred name
- CID 2716
- IUPAC
- [3-(carbamoylamino)-2-methoxypropyl]-chloromercury
- English name
- chlormerodrin
- Molecular formula
- C5H11ClHgN2O2
- Molecular weight
- 367.21
Names & synonyms
OricurKatonilMerilidMercoralPercapylProMeranMercardoxMercloranMerculestNeogidrin
Database identifiers
- CAS
62-37-3- PubChem CID
- 2716
Properties
Computed structural properties
- Topological polar surface area
- 64.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 125
Experimental & physicochemical properties
LogP-0.80
Solubility2.92e+01 g/L
Melting Point152.5 °C
Physical DescriptionSolid
Physicochemical properties
- Melting point
- 152 · 152-153°
- Boiling point
- 142 °C · 142°C
- form
- solid
- FDA UNII
- 99 T5TWO621 · 99T5TWO621
- Toxicity
- 50 orally · LD50 orally in rats: ~82 mg/kg (Goldenthal)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 orally in rats: ~82 mg/kg (Goldenthal)
Chemistry & industry
Pharmacology
PharmacodynamicsChlormerodrin is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.
Mechanism of Action
Chlormerodrin most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na<sup>+</sup> ion, Cl<sup>-</sup> ion and water into the cells, without interfering with the active extrusion of Na<sup>+</sup> ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.
Cellular LocationsMembrane
Applications
UsesChlormerodrin is a sulfhydryl blocking agent; using NK cells, particularly CAR-modified NK cells, for producing induced cellular vesicles (ICVs) loaded with chemotherapeutic agent(s) for cancer therapy.
Upstream & downstream products
Upstream raw materials
Suppliers2 total
斯派螺（武汉）药物研发有限公司[email protected]
陕西缔都医药化工有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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