1,3-Benzenediamine, 2-methyl-, hydrochloride (1:2)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of November 6, 2012: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=15481-70-6]

2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)

TR-200: Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 15481-70-6) (1980 )

02/15/80

No Evidence

No Evidence

No Evidence

/LABORATORY ANIMALS: Acute Exposure/ The acute oral toxicity of toluene-2,6-diamine (2,6-TDA) or its dihydrochloride salt was moderate in rats but (based on a single study) high in mice.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Repeated oral administration of toluene-2,6-diamine dihydrochloride to rats affected various organs including the thyroid gland, bone marrow, heart and liver, while similar studies in mice revealed heart, liver and uterus abnormalities.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ A bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity was conducted by feeding diets containing the test chemical to F344 rats and B6C3F1 mice. Groups of 50 rats of each sex were fed the test chemical at 250 or 500 ppm, for 103 weeks. Groups of 50 mice of each sex fed the test chemical at two doses, 50 or 100 ppm, for 103 weeks. Groups of 50 untreated rats and 50 untreated mice of each sex were used as matched controls. In male rats, islet-cell adenomas of the pancreas and neoplastic nodules or carcinomas of the liver occurred in non-significant dose-related trends.The occurrences of tumor in dosed female rats were not significantly different from those in control rats. Significant results in the negative direction were observed in the incidences of C-cell tumors of the thyroid in male rats and of fibroadenomas of the mammary gland in female rats. In low dose male mice, lymphomas but were not statistically significant, and the occurrence of hepatocellular carcinomas in female mice was dose related but not statistically significant. It was concluded that, under conditions of the bioassay, 2,6- toluenediamine dihydrochloride was not carcinogenicity for male and female F344 rats or for male and female B6C3F1 mice.

/GENOTOXICITY/ In genotoxicity tests in rodents, however, 2,6-TDA or its dihydrochloride induced chromosomal and DNA damage after intraperitoneal injection or oral dosing, while various assays in mammalian cells were similarly positive. Mutagenic activity was evident in Ames bacterial tests.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

F344 rats of each sex were fed 2,6-toluenediamine dihydrochloride at 250 or 500 ppm for 103 wk; B6C3F1 mice of each sex were fed at 2 doses, 50 or 100 ppm for 103 wk. 2,6-Toluenediamine dihydrochloride was not carcinogenic for male and female rats or for male and female mice.