1-(Tetrahydro-2-furoyl)piperazine (HCID 2734641)

Overview

1-(Tetrahydro-2-furoyl)piperazine is a member of phytanoyl-CoAs.

Names & identifiers

Preferred name: 1-(Tetrahydro-2-furoyl)piperazine
IUPAC: oxolan-2-yl(piperazin-1-yl)methanone
English name: 1-(Tetrahydro-2-furoyl)piperazine
Molecular formula: C9H16N2O2
Molecular weight: 184.24

Names & synonyms

1-(Tetrahydro-2-furoyl)piperazineRefChem:428724613-137-163074-07-71-(2-tetrahydrofuroyl)piperazinepiperazin-1-yl(tetrahydrofuran-2-yl)methanone1-(2-Tetrahydrofuroyl)-piperazineoxolan-2-yl(piperazin-1-yl)methanone1-(oxolane-2-carbonyl)piperazineMFCD00190247Terazosin EP Impurity N1-(tetrahydrofuran-2-ylcarbonyl)piperazine

Show more names

TIMTEC-BB SBB005794RARECHEM AH CK 0199Terazosin Impurity 2Terazosin Impurity18Tetrahydro piperazineTETRAHYDROFUROYL PIPERAZINEN-(2-Terahydro-furoyl)piperazine

N-(Tetrahydro-2-furoyl)piperazine1-(tetrahydro-2-furoyl)-piperazinen-(2-tetrahydrofuroyl)piperazinepiperazin-1-yl-(tetrahydro-furan-2-yl)-methanoneMETHANONE, 1-PIPERAZINYL(TETRAHYDRO-2-FURANYL)-4-((Tetrahydrofuran-2-yl)carbonyl)piperazineD9EO38Y0851-(((2RS)-Tetrahydrofuran-2-yl)carbonyl)piperazine

Database identifiers

CAS: 63074-07-7
PubChem CID: 2734641
DTXSID: DTXSID00866966
ChEBI: CHEBI:188788
UNII: D9EO38Y085
EC Number: 613-137-1
Nikkaji: J829.713D

Properties

Computed structural properties

XLogP: -0.5
Topological polar surface area: 41.6 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 3
Rotatable bonds: 1
Heavy atoms: 13
Formal charge: 0
Complexity: 190

Physicochemical properties

Boiling point: 140 °C · 140 °C (1.5002 mmHg)
Density: 1.17 · 1.17
refractive index: 1.5195 · 1.5195-1.5215
Flash point: 120 · 120-125°C/0.2mm
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Viscous Liquid
pka: 8.37 · 8.37±0.10(Predicted)
color: Colorless to yellow
Water Solubility: Fully miscible in water.
BRN: 880578 · 880578
InChI: 1S/C9H16N2O2/c12-9(8-2-1-7-13-8)11-5-3-10-4-6-11/h8,10H,1-7H2
InChIKey: UKESBLFBQANJHH-UHFFFAOYSA-N
SMILES: O=C(C1CCCO1)N2CCNCC2
CAS DataBase Reference: 63074 · 63074-07-7(CAS DataBase Reference)
FDA UNII: 9 EO38Y085 · D9EO38Y085
UNSPSC Code: 41116107 · 41116107
NACRES: 24 · NA.24
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 319 · H319
Precautionary statements: 264 · P264-P280-P305+P351+P338-P337+P313
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38-36
Safety Statements: 37 · 37/39-26-37
WGK Germany: 3 · 3
Hazard Note: Irritant
HS Code: 29349990 · 29349990
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 2 · Eye Irrit. 2

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 45.2% (42 of 93) of reports.

Warning

H319 (50.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)

Aggregated GHS information provided per 93 reports by companies from 8 notifications to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesEye Irrit. 2A (50.5%)

Safety data

wgk: 3
hs_code: 29349990
risk_code: 36/37/38-36
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
hazard_note: Irritant
safety_code: 37/39-26-37
Storage Class: 10 - Combustible liquids
Hazard statements: H319
Hazard Classifications: Eye Irrit. 2
Precautionary statements: P264-P280-P305+P351+P338-P337+P313

Chemistry & industry

Applications

Uses1-(Tetrahydro-2-furoyl)-piperazine (Terazosin EP Impurity N) has been used as a reactant for the preparation of pyrazol-3-propanoic acid derivatives as inhibitors of leukotriene biosynthesis in human neutrophils.