Basic information
- CAS
53267-01-9- Standard SMILES
c1ccc(C2(c3ccccc3)CC2C2=NCCN2)cc1- InChIKey
IPOBOOXFSRWSHL-UHFFFAOYSA-N- Molecular formula
- C18H18N2
- Average molar mass
- 262.3 g/mol
- Monoisotopic mass
- 262.14699858
Overview
Cibenzoline is a diarylmethane.
Names & identifiers
- Preferred name
- Cibenzoline
- IUPAC
- 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
- English name
- Cibenzoline
- Molecular formula
- C18H18N2
- Molecular weight
- 262.35
Names & synonyms
Cibenzoline53267-01-9Cifenline2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazoleCibenzolinumCibenzolinaRo 22-77962-(2,2-diphenylcyclopropyl)-2-imidazolineZ7489237QTDTXSID9022819RO-22-7796RefChem:126085
Show more names
ExacorCibenolUP 33-901MoracizinCibenzoline D4
DTXCID702819C01BG07258-453-7Cifenline [USAN]Cibenzoline [INN]MFCD00864706CHEMBL87045Cibenzoline (INN)
Database identifiers
- CAS
53267-01-9- PubChem CID
- 2747
- DTXSID
DTXSID9022819- ChEMBL
CHEMBL87045- ChEBI
CHEBI:135083- UNII
- Z7489237QT
- EC Number
- 258-453-7
- Nikkaji
- J10.744A
Properties
Computed structural properties
- XLogP
- 2.7
- Topological polar surface area
- 24.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 3
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 357
Physicochemical properties
- Melting point
- 103 · 103-104°
- Boiling point
- 449.2 · 449.2±45.0 °C(Predicted)
- Density
- 1.17 · 1.17±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.82 · 10.82±0.40(Predicted)
- color
- White to Pale Yellow
- CAS DataBase Reference
- 53267 · 53267-01-9
- FDA UNII
- 7489237 QT · Z7489237QT
- ATC code
- 1 BG07 · C01BG07
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H302
- Precautionary statements
- 264 · P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501
- Toxicity
- 100 in · LD100 in rats (mg/kg): 64 i.v. (Cognaco)
- REACH Registrations
- Active
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P280, P301+P317, P302+P352, P321, P330, P332+P317, P362+P364, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Regulatory InformationREACH registered substance: Cibenzoline (EC: 258-453-7)
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxicology
Drug Induced Liver Injury
Drug-Induced Liver Injury Severity and Toxicity (DILIst)
Cibenzoline
DILI Positive
DOI:10.1016/j.drudis.2019.09.022
Safety data
- Toxicity
- LD100 in rats (mg/kg): 64 i.v. (Cognaco)
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H315-H302
- REACH Registrations
- Active
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
ATC Code
C - Cardiovascular system
QC - Cardiovascular system
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Applications
DescriptionCibenzoline is a structurally novel, class I (quinidine-like) antiarrhythmic agent. It has additional properties of class III and class IV compounds, delaying repolarization and antagonizing the positive inotropic effects of calcium.
UsesCibenzoline acts as a highly active class I antiarrhythmic agent.
UsesCardiac depressant.
Upstream & downstream products
Upstream raw materials
Suppliers23 total
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
Aladdin Scientific[email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
VDM Biochemicals0330-2528181 · [email protected]
深圳菲斯生物科技有限公司0755-83725681-603
江苏艾康生物医药研发有限公司025-66028182 17714375163 · [email protected]
TLC梯尔希（南京）药物研发有限公司18012923235 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
BOC Sciences16314854226 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
上海超岚化工科技中心QQ：65489617 13301690235 · [email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
重庆卡兰医药有限公司[email protected]
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
苏州宸瑞生物科技有限公司17625585511 · [email protected]
南京世洲生物科技有限公司17301488900 · [email protected]
常州辰鸿生物科技有限公司+86-0519-85788828 +86-13775037613 · [email protected]
Additional notes
DefinitionChEBI: Cibenzoline is a diarylmethane.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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