Basic information
- CAS
15826-37-6- Standard SMILES
O=C([O-])c1cc(=O)c2c(OCC(O)COc3cccc4oc(C(=O)[O-])cc(=O)c34)cccc2o1.[Na+].[Na+]- InChIKey
VLARUOGDXDTHEH-UHFFFAOYSA-L- Molecular formula
- C23H14Na2O11
- Average molar mass
- 512.3 g/mol
- Monoisotopic mass
- 512.03314982
Overview
Disodium cromoglycate is an organic sodium salt that is the disodium salt of cromoglycic acid. It has a role as an anti-asthmatic drug and a drug allergen. It contains a cromoglycate(2-).
Names & identifiers
- Preferred name
- Disodium Cromoglycate
- IUPAC
- disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
- English name
- Cromolyn Disodium Salt
- Molecular formula
- C23H17NaO11
- Molecular weight
- 492.37
Names & synonyms
CROMOLYN SODIUM15826-37-6Sodium cromoglycateDisodium cromoglycatesodium cromoglicateSodium cromolynGastrocromCromolyn disodium saltCromopticCrolomNatrii cromoglicasCromoglycate disodium
Show more names
CromoglycatenatriumcromoglicatCromoglycate SodiumintalAllergocrom
Natrium cromoglicatCromoglicate SodiumLomusolRynacromAstilynDisodium cromolynDSCGDTXSID7044554
Database identifiers
- CAS
15826-37-6- PubChem CID
- 27503
- DTXSID
DTXSID7044554- ChEMBL
CHEMBL74- ChEBI
CHEBI:128458- UNII
- Q2WXR1I0PK
- EC Number
- 239-926-7
- Nikkaji
- J9.015H
Properties
Computed structural properties
- Topological polar surface area
- 172 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 11
- Rotatable bonds
- 6
- Heavy atoms
- 36
- Formal charge
- 0
- Complexity
- 824
Experimental & physicochemical properties
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Allergic Agents; Anti-Asthmatic Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section205.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 241 · 241-2420C (dec)
- storage temp.
- 2 · 2-8°C
- solubility
- Soluble in water, practically insoluble in ethanol (96 per cent).
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 100 mg/ml · Soluble in water to 100mg/ml
- Merck
- 14 · 14,2590
- Stability
- Hygroscopyc
- Cosmetics Ingredients Functions
- ANTI-SEBUM
- InChIKey
- VLARUOGDXDTHEH-UHFFFAOYSA-L
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 2% (2 of 98) of reports.
Warning
H315 (96.9%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 98 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Other Safety InformationIMAP assessments - 4H-1-Benzopyran-2-carboxylic acid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-, disodium salt: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (96.9%)
Toxicology
Adverse Effects
The frequency of adverse events in patients using cromolyn sodium remains unclear. Adverse events also vary depending on the administration route. The ophthalmic solution is associated with transient eye burning upon administration, and eye dryness, puffiness, irritation, itchiness, rash, and styes may be seen. Adverse events reported with the cromolyn sodium nasal spray were nasal congestion, sneezing, nasal itching, nosebleeds, rhinoconjunctivitis, and headaches. Adverse events reported with the inhalation solution were throat irritation and hoarseness, esophagitis, laryngeal and pharyngeal edema, drowsiness, dizziness, bronchial irritation, pulmonary infiltrates, and cough.
Toxicity Summary
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
CROMOLYN SODIUM
Decreased Histamine Release [PE]; Mast Cell Stabilizer [EPC]
CROMOLYN SODIUM INHALATION SOLUTION
Mast Cell Stabilizer [EPC]; Decreased Histamine Release [PE]
CROMOLYN SODIUM ORAL SOLUTION (CONCENTRATE)
Decreased Histamine Release [PE]; Mast Cell Stabilizer [EPC]
MeSH Pharmacological Classification
Compounds that prevent the release of inflammatory mediators from MAST CELLS.
Drugs that are used to treat asthma.
Applications
DescriptionSodium cromoglycate is the sodium salt and common market from of cromoglicic acid, which is a synthetic compound, and as a mast cell stabilizer. It is capable of inhibiting the antigen-induced bronchospasms, and thus being used to treat the asthma and allergic rhinitis. It can also be applied as an ophthalmic solution for the treatment of conjunctivitis and systemic mastocytosis and ulcerative colitis. It is capable of inhibiting the degranulation of mast cells, further preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), the mediators of type I allergic reaction. It is also capable of inhibiting the release of inflammatory leukotrienes and inhibiting calcium influx.
DescriptionDisodium cromoglycateis a relatively nontoxic agent used for the long-term prevention of many types of asthma. It has no bronchodilator properties and is used in the prophylaxis of asthma. It does not play a role in the treatment of acute asthmatic attacks including severe asthma.
UsesChromone complex which blocks mast cell degranulation
Usesantiasthmatic, antiallergy
UsesAnti Asthamatic
General DescriptionCromolyn sodium, disodium 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane (Intal), isa hygroscopic, white, hydrated crystalline powder that is solublein water (1:10). It is tasteless at first but leaves a veryslightly bitter aftertaste. The pK of cromolyn is 2. It is availableas a solution for a nebulizer, an aerosol spray, a nasal solution,an ophthalmic solution, and an oral concentrate.Nebulized and aerosol cromolyn has been used for prophylacticmanagement of bronchial asthma and prevention ofexercise-induced bronchospasm. Cromolyn nasal solution isused for the prevention and treatment of allergic rhinitis, andoral concentrate is used to treat the histaminic symptomsof mastocytosis (diarrhea, flushing, headaches, vomiting, urticaria,abdominal pain, nausea, and itching). Topical cromolyn(eye drops) is used to treat allergic conjunctivitis andkeratitis. In the treatment of asthma, cromolyn efficacy is manifestedby decreased severity of clinical symptoms, or need for concomitant therapy, or both. Long-term use is justified if thedrug significantly reduces the severity of asthma symptoms;permits a significant reduction in, or elimination of, steroiddosage; or improves management of those who have intolerableside effects to sympathomimetic agents or methylxanthines.For cromolyn to be effective, it must be administered atleast 30 minutes prior to antigen challenge and administered atregular intervals (see dosing information that follows). Wheninhaled, the powder does produce irritation in some patients.Also, overuse of cromolyn can result in tolerance.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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