1-methyl-1H-indazol-5-amine

HCID 2768032
NotesReactions
Substructure searchFind similar structures

Basic information

CAS
50593-24-3
Standard SMILES
Cn1ncc2cc(N)ccc21
InChIKey
PYOFNPHTKBSXOM-UHFFFAOYSA-N
Molecular formula
C8H9N3
Average molar mass
147.18 g/mol
Monoisotopic mass
147.07964729

Names & identifiers

Preferred name
1-methyl-1H-indazol-5-amine
IUPAC
1-methylindazol-5-amine
English name
1-Methyl-1H-indazol-5-amine
Molecular formula
C8H9N3
Molecular weight
147.18

Names & synonyms

1-METHYL-1H-INDAZOL-5-AMINE50593-24-3DTXSID70377635RefChem:231490DTXCID30328663806-999-75-Amino-1-methyl-1H-indazole1-Methyl-1H-indazol-5-ylamine1-methylindazol-5-amineMFCD033054555-AMINO-1-METHYLINDAZOLECHEMBL1650263
Show more names
1-methyl-5-indazolamine1-Methyl-5-amino-1H-indazole1-methyl-1H-indazole-5-amine5-AMino-1-Methyl-1H-indaz...
1H-INDAZOL-5-AMINE, 1-METHYL-1-methyl-5-aminoindazol1-methyl-5-aminoindazole5-amino-1-methyl-indazole1-methyl-indazol-5-ylamineSCHEMBL378619orb3181671SCHEMBL30006507

Database identifiers

CAS
50593-24-3
PubChem CID
2768032
DTXSID
DTXSID70377635
ChEMBL
CHEMBL1650263
EC Number
806-999-7
Nikkaji
J661.384E

Properties

Computed structural properties

XLogP
0.9
Topological polar surface area
43.8 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
2
Rotatable bonds
0
Heavy atoms
11

Physicochemical properties

Melting point
142 · 142-144°C
Boiling point
321.6 · 321.6±15.0 °C(Predicted)
Density
1.27 · 1.27±0.1 g/cm3(Predicted)
storage temp.
Keep in dark place,Inert atmosphere,Room temperature
form
Crystalline Powder
pka
3.85 · 3.85±0.10(Predicted)

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Safety data

hs_code
29339980
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xi
hazard_class
IRRITANT
Hazard statements
H302+H312+H332-H315-H319-H335

Chemistry & industry

Applications · 2 items

Uses1-Methyl-5-amino-1H-indazole is used in preparation of Hydrazone compounds having (Hetero)aryl group at terminal Amine group for treating tau protein-associated disease. Also, used in preparation of Dihydroisoindole-1H-pyrazolo[3,4-d]pyrimidinone compounds as Wee1 inhibitors for treatment of kinase-related diseases.

Uses1-Methyl-5-amino-1H-indazole is used in preparation of Hydrazone compounds having (Hetero)aryl group at terminal Amine group for treating tau protein-associated disease. Also, used in preparation of Dihydroisoindole-1H-pyrazolo[3,4-d]pyrimidinone compounds as Wee1 inhibitors for treatment of kinase-related diseases.

Upstream & downstream products

Suppliers94 total

上海凌富药物研究有限公司+86(21)5895 0110 19945755304 · [email protected]
Hangzhou Collab Medicine Co.,Ltd.+86-15936229464 · [email protected]
杭州鸿喜生物医药科技有限公司18989489206 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]

Related reactions

20 records
New reaction record

Compound notes

Loading…