Basic information
- CAS
636-54-4- Standard SMILES
CC1CCCC(C)N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1- InChIKey
LBXHRAWDUMTPSE-UHFFFAOYSA-N- Molecular formula
- C14H20ClN3O3S
- Average molar mass
- 345.8 g/mol
- Monoisotopic mass
- 345.0913904
Overview
4-chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide is a sulfonamide.
Names & identifiers
- Preferred name
- Brinaldix
- IUPAC
- 4-chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide
- English name
- Clopamide
- Molecular formula
- C14H20ClN3O3S
- Molecular weight
- 345.85
Names & synonyms
ChlosudimeprimylumBrinaldixMLS0005512894-chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamideSMR000145215Chlosudimeprimyl4-Chloro-N-(2,6-dimethyl-piperidin-1-yl)-3-sulfamoyl-benzamideChlorsudimeprimylDT 327NCGC00016527-013563-77-7CAS-636-54-4
Show more names
AquexDT-327AdurixCLOPAMIDECLOPAMIDUMClopamide CRSClopamide (Standard)Clopamide (10mM in DMSO)
Spectrum_001568Opera_ID_864Prestwick0_000354Prestwick1_000354Prestwick2_000354Spectrum2_001595Spectrum3_001891Spectrum4_000207
Database identifiers
- CAS
636-54-4- PubChem CID
- 2804
- DTXSID
DTXSID1022847- ChEBI
CHEBI:95210
Properties
Computed structural properties
- XLogP
- 2.3
- Topological polar surface area
- 101 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 3
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 498
Experimental & physicochemical properties
DrugsPharmaceuticals
LogP1.18
Human DrugsPharmaceuticals
Physicochemical properties
- Melting point
- 248 · 248-249℃
- Density
- 1.39 · 1.39±0.1 g/cm3(Predicted)
- RTECS
- 2338875 · CV2338875
- storage temp.
- 2 · 2-8°C
- solubility
- Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
- pka
- 9.41 · 9.41±0.60(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Yellow
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- risk_code
- 42/43
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- hazard_code
- Xn
- safety_code
- 36
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H317-H334
- Hazard Classifications
- Resp. Sens. 1Skin Sens. 1
- Precautionary statements
- P261-P280-P284-P304+P340-P333+P313-P342+P311
Chemistry & industry
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
UsesAntihypertensive; diuretic.
UsesAntihypertensor;Gonad stimuling agent
UsesClopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.
Suppliers41 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
Sinoway Industrial co., ltd.+86-0592-5800732 +86-13806035118 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
TargetMol 中国（陶术生物）400-821-0310 15002144251 · [email protected]
深圳菲斯生物科技有限公司0755-83725681-603
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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